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Simulated microgravity exposure markedly attenuates the baroreflex total loop gain and induces orthostatic hypotension in male rats. [PDF]

Physiol Rep
Kamada K, Mannoji H, Tohyama T, Nishikawa T, Tsutsui H, Sunagawa K, Saku K.   +6 more
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Experimental Model of HindLimb Suspension-Induced Skeletal Muscle Atrophy in Rodents

Methods in molecular biology, 2018
Due to the difficulty of performing research protocols that reproduce human skeletal muscle disuse conditions, an experimental animal model of "hindlimb suspension" (or hindlimb unloading) was developed. This method was created in the 1970s and utilizes rats and mice to mimic space flight and bed rest in humans.
Gabriel Nasri, Marzuca-Nassr, Kaio Fernando, Vitzel, Gilson Masahiro, Murata, José Luis, Márquez, Rui, Curi   +4 more
openaire   +3 more sources

Effects of hindlimb suspension on development of proximal and distal femur morphological abnormalities in growing rats

Journal of Orthopaedic Research, 2022
Although morphological abnormalities of the femur are known predisposing factors for numerous musculoskeletal disorders, the etiology of these abnormalities is poorly understood.
J. Ozawa, A. Kaneguchi, Shun Ezumi, Takuma Maeno, Jukiya Iwazawa, Kengo Minanimoto, Airi Ikeda   +6 more
semanticscholar   +1 more source

Hindlimb suspension reduces muscle regeneration

European Journal of Applied Physiology, 1998
Exposure of juvenile skeletal muscle to a weightless environment reduces growth and satellite cell mitotic activity. However, the effect of a weightless environment on the satellite cell population during muscle repair remains unknown. Muscle injury was induced in rat soleus muscles using the myotoxic snake venom, notexin.
P E, Mozdziak, Q, Truong, A, Macius, E, Schultz   +3 more
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Percutaneous electrical stimulation-induced muscle contraction prevents the decrease in ribosome RNA and ribosome protein during pelvic hindlimb suspension.

Journal of applied physiology, 2022
Skeletal muscle unloading leads to muscle atrophy. Ribosome synthesis has been implicated as an important skeletal muscle mass regulator owing to its translational capacity.
Takaya Kotani, Yuki Tamura, Karina Kouzaki, Hikaru Kato, Mako Isemura, K. Nakazato   +5 more
semanticscholar   +1 more source

Rat soleus muscle ultrastructure after hindlimb suspension

Journal of Applied Physiology, 1990
The aim of the present investigation was to determine, by quantitative electron microscopy, the effects of a 5-wk tail-suspension period on rat soleus muscle ultrastructure. A marked decline (-60%) in muscle mass occurred. The mean fiber cross-sectional area decreased to a greater extent (-75%) than the capillary-to-fiber ratio (-37%), leading to a ...
D, Desplanches, S R, Kayar, B, Sempore, R, Flandrois, H, Hoppeler   +4 more
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Intracranial Pressure Increases During Hindlimb Suspension

The FASEB Journal, 2016
Introduction One of the responses following exposure to the microgravity spaceflight environment is a pronounced cephalic fluid shift. Recent evidence documents ocular changes in astronauts following long‐duration missions including optic disc edema, globe flattening, choroidal folds and hyperopic shifts.
Heinrich S Gompf, Edward L Robinson, Tana M Hoban‐Higgins, Charles A Fuller   +3 more
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Hindlimb suspension increases insulin binding and glucose metabolism

Journal of Applied Physiology, 1988
After 28 days of hindlimb-suspension, insulin binding, 2-deoxy-D-glucose (2-DG) uptake, and glucose metabolism (glycolysis and glycogenesis) were determined at various insulin concentrations (0.2-30 nM) in soleus muscle of young (18-day-old) and adult (150-day-old) rats.
A, Bonen, G C, Elder, M H, Tan
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