Pharmacological inhibition of endoplasmic reticulum stress mitigates osteoporosis in a mouse model of hindlimb suspension [PDF]
Scientific ReportsHindlimb suspension (HLS) mice exhibit osteoporosis of the hindlimb bones and may be an excellent model to test pharmacological interventions. We investigated the effects of inhibiting endoplasmic reticulum (ER) stress with 4-phenyl butyrate (4-PBA) on ...
Hiba Al-Daghestani +8 more
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Cinnamtannin A2, (-)-epicatechin tetramer, attenuates skeletal muscle wasting in disuse atrophy model mice induced by hindlimb suspension. [PDF]
J Clin Biochem Nutr, 2023 The impact of repeated administration of cinntamtannin A2 (A2, 25 μg/kg) on skeletal muscle disuse atrophy model mice induced by hindlimb suspension for 14 days was examined.
Muta O +9 more
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Treadmill Exercise Suppresses Histological Progression of Disuse Atrophy in Articular Cartilage in Rat Knee Joints during Hindlimb Suspension. [PDF]
Cartilage, 2023 Objective The purpose of this study was to determine the preventive effects of treadmill exercise or physiological loading on disuse atrophy in the rat knee joint cartilage and bone during hindlimb suspension.
Takahashi I +3 more
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Effects of Hindlimb Suspension on the Development of Hip Bone Morphologies in Growing Rats. [PDF]
Physiol ResAbnormal hip bone morphologies are associated with various diseases of the hip joint. Weight bearing, especially during growth, may be important to achieve normal acetabulum development.
Ezumi S +6 more
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Molecular Signaling Effects behind the Spontaneous Soleus Muscle Activity Induced by 7-Day Rat Hindlimb Suspension. [PDF]
Int J Mol SciThe elimination of ground reaction force (support withdrawal) vastly affects slow postural muscles in terms of their regulation and structure. One of the effects of support withdrawal in this study was an immediate postural muscle inactivation, followed ...
Sergeeva XV +4 more
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Exercise preconditioning diminishes skeletal muscle atrophy after hindlimb suspension in mice. [PDF]
J Appl Physiol (1985), 2018 The aim of the present study was to investigate whether short-term, concurrent exercise training before hindlimb suspension (HLS) prevents or diminishes both soleus and gastrocnemius atrophy and to analyze whether changes in mitochondrial molecular markers were associated. Male C57BL/6 mice were assigned to control at 13 ± 1 wk of age, 7-day HLS at 12
Theilen NT +3 more
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Digital Chinese Medicine, 2023 Objective: To explore the therapeutic effects of ginseng total saponins (GTSs) on cognitive impairments in astronauts caused by prolonged exposure to microgravity environment.
Dong Lijinchuan +8 more
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Early Lipid Raft-Related Changes: Interplay between Unilateral Denervation and Hindlimb Suspension. [PDF]
Int J Mol Sci, 2021 Muscle disuse and denervation leads to muscle atrophy, but underlying mechanisms can be different. Previously, we have found ceramide (Cer) accumulation and lipid raft disruption after acute hindlimb suspension (HS), a model of muscle disuse.
Bryndina IG +6 more
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Physiological Reloading Recovers Histologically Disuse Atrophy of the Articular Cartilage and Bone by Hindlimb Suspension in Rat Knee Joint. [PDF]
Cartilage, 2021 Objective This study aimed to clarify physiological reloading on disuse atrophy of the articular cartilage and bone in the rat knee using the hindlimb suspension model.
Takahashi I +3 more
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Soluble RANKL exaggerates hindlimb suspension-induced osteopenia but not muscle protein balance. [PDF]
J Orthop Res, 2021 We examined the hypothesis that exaggerating unloading-induced bone loss using a combination of hindlimb suspension (HLS) and exogenous injections of receptor activator of nuclear factor kappa-B ligand (RANKL) also exaggerates muscle loss.
Speacht TL, Lang CH, Donahue HJ.
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