Time course of hepatic gluconeogenesis during hindlimb suspension unloading [PDF]
Experimental Physiology, 2012 New Findings What is the central question of this study?The rate of liver gluconeogenesis during hindlimb suspension unloading has not been determined. What is the main finding and its importance?Hepatic gluconeogenesis is significantly increased under conditions of hindlimb suspension unloading, which simulates the muscular atrophy occurring during ...
Marco E. Cabrera +4 more
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Pharmacological inhibition of endoplasmic reticulum stress mitigates osteoporosis in a mouse model of hindlimb suspension [PDF]
Scientific ReportsHindlimb suspension (HLS) mice exhibit osteoporosis of the hindlimb bones and may be an excellent model to test pharmacological interventions. We investigated the effects of inhibiting endoplasmic reticulum (ER) stress with 4-phenyl butyrate (4-PBA) on ...
Hiba Al-Daghestani +8 more
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Effect of capsaicin-sensitive sensory neurons on bone architecture and mechanical properties in the rat hindlimb suspension model [PDF]
Journal of Orthopaedic Translation, 2017 Background/Objective: The participation of sensory neural regulation in bone metabolism has been widely studied. However, the physiological role of sensory neural regulation in the functional adaptation to weight bearing is not clear.
Zong-Kang Zhang +3 more
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Frontiers in Physiology, 2020 It is known that nitric oxide (NO) may affect myosin heavy chain (MyHC) isoform mRNA transcription in skeletal muscles. The content of NO in soleus muscles decreases during rat hindlimb unloading as well as slow MyHC mRNA transcription.
Kristina A Sharlo, Anna E Bugrova
exaly +3 more sources
Biomechanics and structural adaptations of the rat femur after hindlimb suspension and treadmill running [PDF]
Brazilian Journal of Medical and Biological Research, 2009 We microscopically and mechanically evaluated the femurs of rats subjected to hindlimb unloading (tail suspension) followed by treadmill training. Female Wistar rats were randomly divided into five groups containing 12-14 rats: control I (118 days old ...
M.M. Shimano, J.B. Volpon
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Early Lipid Raft-Related Changes: Interplay between Unilateral Denervation and Hindlimb Suspension. [PDF]
Int J Mol Sci, 2021 Bryndina IG +6 more
europepmc +3 more sources
Quercetin prevents bone loss in hindlimb suspension mice via stanniocalcin 1-mediated inhibition of osteoclastogenesis. [PDF]
Acta Pharmacol Sin, 2020 Niu YB +10 more
europepmc +3 more sources
Peripheral vascular responses to heat stress after hindlimb suspension
Medicine & Science in Sports & Exercise, 2002 The purpose of this study was to determine whether hindlimb suspension (which simulates the effects of microgravity) results in impaired hemodynamic responses to heat stress or alterations in mesenteric small artery sympathetic nerve innervation.Over 28 d, 16 male Sprague-Dawley rats were hindlimb-suspended, and 13 control rats were housed in the same ...
Carl V. Gisolfi, Robin Looft-Wilson
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TFAM overexpression diminishes skeletal muscle atrophy after hindlimb suspension in mice. [PDF]
Arch Biochem Biophys, 2019 Theilen NT +3 more
europepmc +3 more sources
Alteration of vasopressin-aquaporin system in hindlimb unloading mice [PDF]
Frontiers in PhysiologyMurine hindlimb unloading (HU) is considered a model of choice for simulating the physiological effects of microgravity on several functions, including fluid and electrolyte homeostasis.
Marianna Ranieri +11 more
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