Results 191 to 200 of about 492,458 (242)

Rat small mesenteric artery function after hindlimb suspension

Journal of Applied Physiology, 2000
To determine whether simulated microgravity in rats is associated with vascular dysfunction, we measured responses of isolated, pressurized mesenteric resistance artery segments (157- to 388-μm ID) to vasoconstrictors, pressure, and shear stress after 28-day hindlimb suspension (HS). Results indicated no differences between HS and control (C) groups in
R C, Looft-Wilson, C V, Gisolfi
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NOS‐dependent effects of plantar mechanical stimulation on mechanical characteristics and cytoskeletal proteins in rat soleus muscle during hindlimb suspension

The FASEB Journal, 2021
The study was aimed at investigating the mechanisms and structures which determine mechanical properties of skeletal muscles under gravitational unloading and plantar mechanical stimulation (PMS). We hypothesized that PMS would increase NO production and
S. Tyganov, E. Mochalova, I. Melnikov, I. Vikhlyantsev, A. Ulanova, K. Sharlo, T. Mirzoev, B. Shenkman   +7 more
semanticscholar   +1 more source

Peripheral vascular responses to heat stress after hindlimb suspension

Medicine & Science in Sports & Exercise, 2002
The purpose of this study was to determine whether hindlimb suspension (which simulates the effects of microgravity) results in impaired hemodynamic responses to heat stress or alterations in mesenteric small artery sympathetic nerve innervation.Over 28 d, 16 male Sprague-Dawley rats were hindlimb-suspended, and 13 control rats were housed in the same ...
Robin C, Looft-Wilson, Carl V, Gisolfi
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Hindlimb suspension suppresses muscle growth and satellite cell proliferation

Journal of Applied Physiology, 1989
The effects of long-term hindlimb unweighting by tail suspension on postnatal growth of 20-day rat extensor digitorum longus (EDL) and soleus muscles were studied. Morphological assay indicated that radial growth of soleus myofibers was completely inhibited between 3 and 10 days of suspension and reduced thereafter, leading to a severe attenuation ...
K C, Darr, E, Schultz
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Lack of exercise, via hindlimb suspension, impedes endogenous neurogenesis

Neuroscience, 2007
Bedridden patients who receive good physical rehabilitation are able to exhibit clinical improvement. Accumulating evidence demonstrates that exercise increases endogenous neurogenesis and may even protect against central nervous system (CNS) disorders.
T, Yasuhara, K, Hara, M, Maki, N, Matsukawa, H, Fujino, I, Date, C V, Borlongan   +6 more
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Contractile function of single muscle fibers after hindlimb suspension

Journal of Applied Physiology, 1989
The purpose of this investigation was to determine how muscle atrophy produced by the hindlimb suspension (HS) model alters the contractile function of slow- and fast-twitch single muscle fibers. After 2 wk of HS, small bundles of fibers were isolated from the soleus and the deep and superficial regions of the lateral and medial heads of the ...
Gardetto, P. R., Schluter, Jane Marie, Fitts, Robert H.   +2 more
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Ventral horn cell responses to spaceflight and hindlimb suspension

Journal of Applied Physiology, 1992
Spaceflight or hindlimb suspension results in a loss of mass and alterations of the metabolic and contractile protein profiles of skeletal muscles toward that resembling faster muscles. Given the influence of motoneurons on muscle properties, ventral horn cells of the lumbosacral enlargement of the spinal cord were studied to determine whether similar
B, Jiang, R R, Roy, I V, Polyakov, I B, Krasnov, V R, Edgerton   +4 more
openaire   +2 more sources

Spaceflight and hindlimb suspension disuse models in mice.

Biomedical sciences instrumentation, 2004
Osteoporosis is a disease characterized by low bone mass and structural deterioration of bone tissue, leading to bone fragility and increased susceptibility to fractures. The microgravity of space creates an extreme environment that provides a model for osteoporosis in humans. This greatly accelerated form of osteopenia results in a 0.5-2% loss of bone
Jeffery R, Milstead, Steven J, Simske, Ted A, Bateman   +2 more
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Hindlimb suspension diminishes femoral cross‐sectional growth in the rat

Journal of Orthopaedic Research, 1995
AbstractGrowth, functional adaptation, and torsional strength were examined in the femora of 39‐day‐old male Sprague‐Dawley rats subjected to hindlimb suspension for 0, 1, 2, 3, or 4 weeks and were compared with measurements for age‐matched control animals.
M C, van der Meulen, E R, Morey-Holton, D R, Carter   +2 more
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Single muscle fiber enzyme shifts with hindlimb suspension and immobilization

American Journal of Physiology-Cell Physiology, 1989
The purpose of this investigation was to determine how models of weightlessness, hindlimb suspension (HS), and hindlimb immobilization (HI) affect the metabolic enzyme profile in the slow oxidative (SO), fast oxidative glycolytic (FOG), and fast glycolytic (FG) fibers of rat hindlimb.
Fitts, Robert H., Brimmer, C. J., Heywood-Cooksey, Anne, Timmerman, R. J.   +3 more
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