Results 41 to 50 of about 492,458 (242)

Effect of Long-Term Antiorthostatic Suspension in a Murine Model of Acute Lung Injury [PDF]

Clinical and Experimental Otorhinolaryngology, 2016
Objectives Antiorthostatic suspension (AOS) is ground-based model of simulated microgravity. There is still no study about the effect of long-term microgravity on the clinical course of acute lung injury. We evaluated the effect of simulated microgravity
Tae Young Jang, Ah-Yeoun Jung, Young Hyo Kim   +2 more
doaj   +1 more source

The Impact of Hindlimb Suspension on the Rat Eye: A Molecular and Histological Analysis of the Retina

Gravitational and space research : publication of the American Society for Gravitational and Space Research, 2021
The Spaceflight Associated Neuro-ocular Syndrome (SANS) is hypothesized to be associated with microgravity-induced fluid shifts. There is a need for an animal model of SANS to investigate its pathophysiology.
C. Theriot, P. Chévez-Barrios, T. Loughlin, Afshin Beheshti, N. Mercaldo, S. Zanello   +5 more
semanticscholar   +1 more source

NO-Dependent Mechanisms of Myosin Heavy Chain Transcription Regulation in Rat Soleus Muscle After 7-Days Hindlimb Unloading

Frontiers in Physiology, 2020
It is known that nitric oxide (NO) may affect myosin heavy chain (MyHC) isoform mRNA transcription in skeletal muscles. The content of NO in soleus muscles decreases during rat hindlimb unloading as well as slow MyHC mRNA transcription.
Kristina A. Sharlo, Inna I. Paramonova, Irina D. Lvova, Natalia A. Vilchinskaya, Anna E. Bugrova, Tatiana F. Shevchenko, Grigoriy R. Kalamkarov, Boris S. Shenkman   +7 more
doaj   +1 more source

Muscle Function and Kinematics during Submaximal Equine Jumping: What Can Objective Outcomes Tell Us about Athletic Performance Indicators?

Animals, 2021
Selection and training practices for jumping horses have not yet been validated using objective performance analyses. This study aimed to quantify the differences and relationships between movement and muscle activation strategies in horses with varying ...
Lindsay St. George, Hilary M. Clayton, Jonathan Sinclair, James Richards, Serge H. Roy, Sarah Jane Hobbs   +5 more
doaj   +1 more source

Using Electrical Impedance Myography as a Biomarker of Muscle Deconditioning in Rats Exposed to Micro- and Partial-Gravity Analogs

Frontiers in Physiology, 2020
As astronauts prepare to undertake new extra-terrestrial missions, innovative diagnostic tools are needed to better assess muscle deconditioning during periods of weightlessness and partial gravity.
Carson Semple, Daniela Riveros, Dong-Min Sung, Janice A. Nagy, Seward B. Rutkove, Marie Mortreux   +5 more
doaj   +1 more source

AMPK Phosphorylation Impacts Apoptosis in Differentiating Myoblasts Isolated from Atrophied Rat Soleus Muscle

Cells, 2023
Regrowth of atrophied myofibers depends on muscle satellite cells (SCs) that exist outside the plasma membrane. Muscle atrophy appears to result in reduced number of SCs due to apoptosis.
Natalia A. Vilchinskaya, Sergey V. Rozhkov, Olga V. Turtikova, Timur M. Mirzoev, Boris S. Shenkman   +4 more
doaj   +1 more source

Prochlorperazine Withdraws the Delayed Onset Tonic Activity of Unloaded Rat Soleus Muscle: A Pilot Study

Life, 2021
A gradual increase in rat soleus muscle electromyographic (EMG) activity is known to occur after 3–4 days of hindlimb suspension/unloading (HS). The physiological significance and mechanisms of such activity of motoneurons under unloading conditions are ...
Vitaliy E. Kalashnikov, Sergey A. Tyganov, Olga V. Turtikova, Ekaterina P. Kalashnikova, Margarita V. Glazova, Timur M. Mirzoev, Boris S. Shenkman   +6 more
doaj   +1 more source

Biomechanics and structural adaptations of the rat femur after hindlimb suspension and treadmill running

Brazilian Journal of Medical and Biological Research, 2009
We microscopically and mechanically evaluated the femurs of rats subjected to hindlimb unloading (tail suspension) followed by treadmill training. Female Wistar rats were randomly divided into five groups containing 12-14 rats: control I (118 days old ...
M.M. Shimano, J.B. Volpon
doaj   +1 more source

Low-Molecular-Weight Chondroitin Sulfates Alleviate Simulated Microgravity-Induced Oxidative Stress and Bone Loss in Mice

Current Issues in Molecular Biology, 2023
(1) Background: Many studies have shown that microgravity experienced by astronauts or long-term bedridden patients results in increased oxidative stress and bone loss.
Rong Lan, Ye Li, Xinying Zhao, Rong Shen, Ruili Wang, Ruixin Mao, Shuangsheng Guo   +6 more
doaj   +1 more source

Disuse histological changes of an unloading environment on joint components in rat knee joints

Osteoarthritis and Cartilage Open, 2019
Summary: Objectives: To clarify the effects of mechanical unloading on joint components, including the articular cartilage by knee compartments, synovial membrane, and the infrapatellar fat pad (IFP), using a hindlimb suspension rat model.
Ikufumi Takahashi, Taro Matsuzaki, Hiroshi Kuroki, Masahiro Hoso   +3 more
doaj   +1 more source