Results 41 to 50 of about 13,691 (275)
Positive impact of low-dose, high-energy radiation on bone in partial- and/or full-weightbearing mice [PDF]
, 2019 Astronauts traveling beyond low Earth orbit will be exposed to galactic cosmic radiation (GCR); understanding how high energy ionizing radiation modifies the bone response to mechanical unloading is important to assuring crew health. To investigate this,
Allen, Matthew R. +9 more
core +1 more source
Growth hormone plus resistance exercise attenuate structural changes in rat myotendinous junctions resulting from chronic unloading. [PDF]
, 2013 Myotendinous junctions (MTJs) are specialized sites on the muscle surface where forces generated by myofibrils are transmitted across the sarcolemma to the extracellular matrix.
Burattini, S +8 more
core +2 more sources
Protective Effects of Controlled Mechanical Loading of Bone in C57BL6/J Mice Subject to Disuse
JBMR Plus, 2020 Prolonged reduction in weightbearing causes bone loss. Disuse of bone is associated with recovery from common musculoskeletal injury and trauma, bed rest resulting from various medical conditions, and spaceflight.
Alex DeLong +6 more
doaj +1 more source
Reproductive Biology and Endocrinology, 2021 Background Spaceflights-induced microgravity can alter various physiological processes in human’s body including the functional status of the reproductive system.
Amira Moustafa
doaj +1 more source
A Brief Review of Bone Adaptation to Unloading. [PDF]
, 2008 Weight-bearing bone is constantly adapting its structure and function to mechanical environments. Loading through routine exercises stimulates bone formation and prevents bone loss, but unloading through bed rest and cast immobilization as well as ...
Hamamura, Kazunori +2 more
core +2 more sources
Effect of hindlimb suspension on hippocampal neurogenesis in weaned rats
The FASEB Journal, 2010 Effects of inhibited antigravity activity of hindlimb muscles on the hippocampal neurogenesis were studied in newly weaned rats, using the hindlimb suspension (HS) model. Effects of ambulation recovery were also studied. Brain was fixed by infusion of phosphate buffer with 4% paraformaldehyde in the anesthetized rat and cross‐sectional samples, around ...
Katsuya Kami +7 more
openaire +1 more source
Frontiers in Cell and Developmental Biology, 2021 The partial gravity environment in space can negatively affect bone health. This survey aimed to study the reaction of different parts of the lower limb bones of rats to partial gravity and the effects of different degrees of gravity on these bony parts.
Shenke Zhang +13 more
doaj +1 more source
Rat Pancreatic Response to Simulated Microgravity by Hindlimb Suspension
The FASEB Journal, 2009 Hindlimb suspension (HLS) of rats is a validated model of simulated microgravity representing weightlessness. This study examines the stress response induced by HLS on the structural integrity of endocrine and exocrine pancreas in rats. The influence of a dietary soyprotein meal was also examined.
Parimal Chowdhury +3 more
openaire +2 more sources
BMC Cell Biology, 2010 Background The ability of skeletal muscle to grow and regenerate is dependent on resident stem cells called satellite cells. It has been shown that chronic hindlimb unloading downregulates the satellite cell activity.
Zhang Hong-Yu +8 more
doaj +1 more source
Biomolecules, 2020 Perlecan/Hspg2, a large monomeric heparan sulfate proteoglycan, is found in the basement membrane and extracellular matrix, where it acts as a matrix scaffold, growth factor depot, and tissue barrier.
Ashutosh Parajuli +8 more
doaj +1 more source