Results 51 to 60 of about 492,458 (242)

INDICATORS OF PHYSICAL STRESS DURING HINDLIMB SUSPENSION IN WISTAR RATS / INDICADORES DE STRESS FÍSICO DURANTE A SUSPENSÃO DOS MEMBROS INFERIORES EM RATOS WISTAR

, 2020
Hindlimb suspension (HS) has been used in animal research as a microgravity simulation model. However, physical stress to the animals during suspension has received little attention.
Maurílio Tiradentes Dutra, B Girgis, António Bovolini, Catarina Costa, Grace Fernanda Severino Nunes, José Alberto Duarte   +5 more
openalex   +2 more sources

Metformin Pre-Treatment as a Means of Mitigating Disuse-Induced Rat Soleus Muscle Wasting

Current Issues in Molecular Biology, 2023
Currently, no ideal treatment exists to combat skeletal muscle disuse-induced atrophy and loss of strength. Because the activity of AMP-activated protein kinase (AMPK) in rat soleus muscle is suppressed at the early stages of disuse, we hypothesized that
Timur M. Mirzoev, Inna I. Paramonova, Sergey V. Rozhkov, Ekaterina P. Kalashnikova, Svetlana P. Belova, Sergey A. Tyganov, Natalia A. Vilchinskaya, Boris S. Shenkman   +7 more
doaj   +1 more source

Protective Effects of Controlled Mechanical Loading of Bone in C57BL6/J Mice Subject to Disuse

JBMR Plus, 2020
Prolonged reduction in weightbearing causes bone loss. Disuse of bone is associated with recovery from common musculoskeletal injury and trauma, bed rest resulting from various medical conditions, and spaceflight.
Alex DeLong, Michael A Friedman, Scott M Tucker, Andrew R Krause, Allen Kunselman, Henry J Donahue, Gregory S Lewis   +6 more
doaj   +1 more source

The effects of low frequency electrical stimulation on satellite cell activity in rat skeletal muscle during hindlimb suspension

BMC Cell Biology, 2010
Background The ability of skeletal muscle to grow and regenerate is dependent on resident stem cells called satellite cells. It has been shown that chronic hindlimb unloading downregulates the satellite cell activity.
Zhang Hong-Yu, Ling Shu-Kuan, Wan Yu-Min, Wang Hong-Hui, Liu Yue, Yeung Simon S, Zhang Bao-Ting, Li Ying-Hui, Yeung Ella W   +8 more
doaj   +1 more source

Hindlimb unloading-induced reproductive suppression via Downregulation of hypothalamic Kiss-1 expression in adult male rats

Reproductive Biology and Endocrinology, 2021
Background Spaceflights-induced microgravity can alter various physiological processes in human’s body including the functional status of the reproductive system.
Amira Moustafa
doaj   +1 more source

Depression of Bone Density at the Weight-Bearing Joints in Wistar Hannover Rats by a Simulated Mechanical Stress Associated With Partial Gravity Environment

Frontiers in Cell and Developmental Biology, 2021
The partial gravity environment in space can negatively affect bone health. This survey aimed to study the reaction of different parts of the lower limb bones of rats to partial gravity and the effects of different degrees of gravity on these bony parts.
Shenke Zhang, Daishin Ueno, Takashi Ohira, Takashi Ohira, Takashi Ohira, Hisashi Kato, Hisashi Kato, Tetsuya Izawa, Tetsuya Izawa, Sakuya Yamanouchi, Yukari Yoshida, Akihisa Takahashi, Yoshinobu Ohira, Yoshinobu Ohira   +13 more
doaj   +1 more source

A Canine Musculoskeletal Robot for Investigating Biomechanical Functions During Locomotion

Advanced Robotics Research, EarlyView.
In this study, a dog limb musculoskeletal robot was developed using thin McKibben artificial muscles to investigate the effects of the dog's musculoskeletal structure on walking. Walking experiments were conducted in both indoor and outdoor environments, suggesting that the flexible structure of the dog's shoulders contributes to an increase in stroke ...
Hana Ito, Shoma Tanaka, Yunhao Feng, Hiroyuki Nabae, Yasuji Harada, Akira Fukuhara, Koichi Suzumori   +6 more
wiley   +1 more source

Extracellular vesicle distribution and localization in skeletal muscle at rest and following disuse atrophy

Skeletal Muscle, 2023
Background Skeletal muscle (SkM) is a large, secretory organ that produces and releases myokines that can have autocrine, paracrine, and endocrine effects.
Ahmed Ismaeel, Douglas W. Van Pelt, Zachary R. Hettinger, Xu Fu, Christopher I. Richards, Timothy A. Butterfield, Jonathan J. Petrocelli, Ivan J. Vechetti, Amy L. Confides, Micah J. Drummond, Esther E. Dupont-Versteegden   +10 more
doaj   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source