Results 71 to 80 of about 492,458 (242)
Frontiers in Psychiatry, 2021 Background: Our studies demonstrated that the space environment has an impact on the brain function of astronauts. Numerous ground-based microgravity and social isolation showed that the space environment can induce brain function damages in humans and ...
Qiong Wang +16 more
doaj +1 more source
Rat Pancreatic Response to Simulated Microgravity by Hindlimb Suspension
The FASEB Journal, 2009 Hindlimb suspension (HLS) of rats is a validated model of simulated microgravity representing weightlessness. This study examines the stress response induced by HLS on the structural integrity of endocrine and exocrine pancreas in rats. The influence of a dietary soyprotein meal was also examined.
Parimal Chowdhury +3 more
openaire +1 more source
Advanced Science, EarlyView.Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang +16 more
wiley +1 more source
Advanced Science, EarlyView.A macrophage–platelet conjugation system (M‐P‐NPs@PPARγ) targets injure tissue to co‐deliver platelet mitochondria and PPARγ‐encoding NPs. This strategy boosts the macrophage energy supply and restores lipid homeostasis, leading to synergistically enhanced efferocytosis and tissue repair Abstract Mitochondrial dysfunction occurs in macrophages with ...
Haoli Wang +18 more
wiley +1 more source
Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology
Advanced Science, EarlyView.Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto +11 more
wiley +1 more source
Advanced Science, EarlyView.This study presents a novel “in vivo–in vitro” therapeutic strategy for spinal cord injury by leveraging magnetically responsive piezoelectric nanomaterials. These nanomaterials enable targeted delivery of localized electrical stimulation at the injury site through noninvasive external magnetic actuation, thereby promoting axonal regeneration and ...
Zhihang Xiao +9 more
wiley +1 more source
Advanced Science, EarlyView.A multifunctional mPDZM nanoplatform is developed in this study. mPDZM integrates chemotherapy‐induced senescence, selective senolysis, and STING‐mediated immune activation. mPDZM effectively clears senescent tumor cells, remodels the tumor immune microenvironment, and enhances antitumor T‐cell responses.
Shiji Fang +17 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals that Schwann cell FDFT1‐mediated cholesterol synthesis is essential for peripheral nerve regeneration via dual roles: as a structural component for myelin and as a metabolic signal that upregulates IGF1. IGF1 promotes axonal growth through paracrine action and enhances Schwann cell differentiation/ myelination via an intrinsic IGF1R ...
Shuyi Xu +12 more
wiley +1 more source
The Effects of Simulated Microgravity on Serum Levels of VEGF in Male Wistar Rats [PDF]
فصلنامه علوم و فناوری فضایی, 2017 Endothelial cells differently respond to microgravity condition. The evolution of these responses leads to a more clear understanding of cardiovascular diseases in both gravity and micro-gravity conditions.
Vahid Nikbakht +4 more
doaj
Stem Cell Research & Therapy, 2023 Background Peripheral artery disease is an ischemic vascular disease caused by the blockage of blood vessels supplying blood to the lower extremities.
Young Cheol Song +9 more
doaj +1 more source