Hypoxia Induces Alterations in the Circadian Rhythm in Patients with Chronic Respiratory Diseases [PDF]
The function of the circadian cycle is to determine the natural 24 h biological rhythm, which includes physiological, metabolic, and hormonal changes that occur daily in the body.
Manuel Castillejos-López +17 more
doaj +2 more sources
Factores de riesgo de asma, alergia e hiperreactividad bronquial en niños de 6 a 8 años
Objetivo Determinar los factores de riesgo de asma, alergia y de hiperreactividad bronquial en ninos de 6 a 8 anos de Huesca. Pacientes y metodos Estudio transversal de asma, rinitis y dermatitis-eccema por encuesta, prick test e hiperreactividad bronquial (prueba de carrera libre, volumen espiratorio maximo en el primer segundo [FEV1]) en una ...
E Gonzalez Pérez-Yarza
exaly +2 more sources
The role of sex hormones in lung is known. The three main sex steroid receptors, estrogen, progesterone, and androgen, have not been sufficiently studied in airway smooth muscle cells (ASMC), and the sex hormone regulation on these receptors is unknown ...
Abraham Zarazúa +5 more
doaj +2 more sources
Functional Repercussions of Hypoxia-Inducible Factor-2α in Idiopathic Pulmonary Fibrosis [PDF]
Hypoxia and hypoxia-inducible factors (HIFs) are essential in regulating several cellular processes, such as survival, differentiation, and the cell cycle; this adaptation is orchestrated in a complex way.
Ana Karen Torres-Soria +14 more
doaj +2 more sources
Light-Responsive and Dual-Targeting Liposomes: From Mechanisms to Targeting Strategies [PDF]
In recent years, nanocarriers have played an ever-increasing role in clinical and biomedical applications owing to their unique physicochemical properties and surface functionalities. Lately, much effort has been directed towards the development of smart,
Ahmed M. Agiba +3 more
doaj +2 more sources
Advancing Photodynamic Cancer Therapy with Smart Light-Responsive Lipid and Polymeric Nanocarriers: Evidence from a Meta-Analysis of Efficacy and Pharmacokinetics [PDF]
Background/Objectives: Conventional anticancer drugs often exhibit limited solubility and bioavailability due to unfavorable physicochemical properties and inherent physiological barriers.
Ahmed M. Agiba +6 more
doaj +2 more sources
Nanotechnology and Matrix Metalloproteinases in Cancer Diagnosis and Treatment [PDF]
Cancer is still one of the leading causes of death worldwide. This great mortality is due to its late diagnosis when the disease is already at advanced stages.
Georgina Gonzalez-Avila +4 more
doaj +2 more sources
Tumor necrosis factor alpha (TNF-α) is a potent proinflammatory cytokine that plays a significant role in the pathogenesis of asthma by inducing hyperresponsiveness and airway remodeling. TNF-α diminishes the L-type voltage dependent Ca2+ channel (L-VDCC)
Jorge Reyes-García +6 more
doaj +2 more sources
Psychotic Disorder Secondary to Cerebral Venous Thrombosis Caused by Primary Thrombophilia in a Pediatric Patient with Protein S Deficiency and an MTHFR p.Ala222Val Variant: A Case Report [PDF]
Background and Clinical Significance: Herein, we describe the clinical case of a 17-year-old patient with psychotic disorder secondary to cerebral venous thrombosis due to primary thrombophilia, which was related to protein S deficiency and a ...
Darío Martínez-Pascual +11 more
doaj +2 more sources
Antecedentes No hay datos concluyentes sobre los factores de riesgo que modifican de alguna forma la hiperreactividad bron-quial despues de haber expuesto la via respiratoria a un factor modulador, como histamina, metacolina o ejercicio. Algunos factores como la contaminacion ambiental o las propias infecciones, en determinadas circunstancias, po ...
O Vall Combelles
exaly +2 more sources

