Results 101 to 110 of about 250,571 (331)

A Rapid Cortical Learning Process Supporting Students’ Knowledge Construction During Real Classroom Teaching

Advanced Science, EarlyView.
There is growing interest in understanding how classroom teaching works, but previous theories and studies leave a gap in the neurocognitive mechanisms involved in real classroom teaching. Here we show that during real classroom teaching, students' middle frontal cortex serves as a hub of a rapid cortical learning process, supporting their knowledge ...
Xiaodan Feng, Xinran Xu, Zhaonan Meng, Jiahao Jiang, Miao Pei, Yonghe Zheng, Chunming Lu   +6 more
wiley   +1 more source

Properties of Contextual Memory Formed in the Absence of αCaMKII Autophosphorylation

Molecular Brain, 2011
The alpha-isoform of calcium/calmodulin-dependent kinase II (αCaMKII) is a major synaptic kinase that undergoes autophosphorylation after NMDA receptor activation, switching the kinase into a calcium-independent activity state.
Irvine Elaine E, Danhiez Arthur, Radwanska Kasia, Nassim Charlotte, Lucchesi Walter, Godaux Emile, Ris Laurence, Giese K   +7 more
doaj   +1 more source

High‐Throughput Proteoform Imaging for Revealing Spatial‐Resolved Changes in Brain Tissues Associated with Alzheimer's Disease

Advanced Science, EarlyView.
High‐throughput proteoform imaging (HTPi) is established by combining matrix‐assisted laser desorption ionization mass spectrometry imaging and high‐sensitivity region‐specific top‐down proteomic analysis. HTPi enables the generation of annotated proteoform images with exceptional precision, high throughput, and deep coverage, showing distinct spatial ...
Yue Sun, Dan Liu, Yu Liang, Xue Yang, Xinxin Liu, Baofeng Zhao, Zhen Liang, Yukui Zhang, Lihua Zhang   +8 more
wiley   +1 more source

Structure and evolution of neuronal wiring receptors and ligands

Developmental Dynamics, Volume 252, Issue 1, Page 27-60, January 2023., 2023
Abstract One of the fundamental properties of a neuronal circuit is the map of its connections. The cellular and developmental processes that allow for the growth of axons and dendrites, selection of synaptic targets, and formation of functional synapses use neuronal surface receptors and their interactions with other surface receptors, secreted ...
Elena Cortés, Joseph S. Pak, Engin Özkan   +2 more
wiley   +1 more source

Micro‐Coil Neuromodulation at Single‐Cell and Circuit Levels for Inhibiting Natural Neuroactivity, Neutralizing Electric Neural Excitation, and Suppressing Seizures

Advanced Science, EarlyView.
Micromagnetic stimulation (µMS) offers a precise method for neural inhibition, complementing existing neuromodulation techniques. Using an implantable micro‐coil device, µMS selectively suppresses cortical activity with high spatial resolution. It effectively counteracts micro‐electrode stimulation and reduces seizure amplitude, highlighting its ...
Kayeon Kim, Xiyuan Liu, Bingdong Chang, Guanghui Li, Gwendoline A. E. Anand, Su Genelioglu, Alexandra Katherine Isis Yonza, Andrew J Whalen, Rune W Berg, Shelley I Fried, Anpan Han, Changsi Cai   +11 more
wiley   +1 more source

Nimesulide limits kainate-induced oxidative damage in the rat hippocampus [PDF]

European Journal of Pharmacology 390(3): 295-298 (2000), 2007
Kainate induces a marked expression of cyclooxygenase-2 after its systemic administration. Because cyclooxygenase-2 activity is associated to the production of reactive oxygen species, we investigated the effects of nimesulide, a selective cyclooxygenase-2 inhibitor, on kainate-induced in vivo oxidative damage in the rat hippocampus.
arxiv  

Photo‐Biomodulation of the Hippocampus Using Near‐Infrared Laser to Enhance Cognitive Function in Mice

Advanced Science, EarlyView.
Here a transcranial photo‐biomodulation approach is developed using near‐infrared (NIR) laser on hippocampus of mice, revealing significant improvements in learning and memory ability of mice under normal and disease conditions. The improvement results from the high‐density cell‐induced NIR local energy deposition, neuronal activation, and axonogenesis
Wei‐Tong Pan, Han‐Wen Gu, Yan‐Bo Zhou, Sophie Ma, Daqing Ma, Pan‐Miao Liu, Jian‐Jun Yang   +6 more
wiley   +1 more source

Unraveling the Hippocampal Molecular and Cellular Alterations behind Tramadol and Tapentadol Neurobehavioral Toxicity

Pharmaceuticals
Tramadol and tapentadol are chemically related opioids prescribed for the analgesia of moderate to severe pain. Although safer than classical opioids, they are associated with neurotoxicity and behavioral dysfunction, which arise as a concern ...
Cristiana Soares-Cardoso, Sandra Leal, Susana I. Sá, Rita Dantas-Barros, Ricardo Jorge Dinis-Oliveira, Juliana Faria, Joana Barbosa   +6 more
doaj   +1 more source

Reduced Cyclic Adenosine Monophosphate Level in Hippocampal CA1 Participates in Propofol Induced Amnesia in Rats

Frontiers in Neuroscience, 2018
Propofol inhibits long-term potentiation (LTP) in the hippocampal CA1 region and impedes episodic memory formation. However, the molecular mechanisms involved in the effect of propofol are still poorly understood.
Weiwei Li, Weiwei Li, Weiwei Li, Lingling Yu, Xiaodi Yan, Linlin Cai, Li Wan, Qinyu Teng, Yonghua Li, Yun Wang, Haitao Xu   +10 more
doaj   +1 more source

Finite element analysis of neuronal electric fields: the effect of heterogeneous resistivity [PDF]

arXiv, 2012
Simulation of extracellular fields is one of the substantial methods used in the area of computational neuroscience. Its most common usage is validation of experimental methods as EEG and extracellular spike recordings or modeling of physiological phenomena which can not be easily determined empirically. Continuous experimental work has been re-raising
arxiv