Results 171 to 180 of about 249,413 (328)

A Topological Paradigm for Hippocampal Spatial Map Formation Using Persistent Homology

, 2012
Yuri Dabaghian, Facundo Mémoli, Loren M. Frank, Gunnar Carlsson   +3 more
openalex   +2 more sources

S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning

Advanced Science, EarlyView.
Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu, Penglei Wang, Gaoyuan Xu, Jitao Lu, Qinke Peng, Danyang Wu, Hequan Sun   +6 more
wiley   +1 more source

iGluR expression in the hippocampal formation, entorhinal cortex, and superior temporal gyrus in Alzheimer's disease. [PDF]

Neural Regen Res, 2022
Y Yeung JH, Waldvogel HJ, M Faull RL, Kwakowsky A.   +3 more
europepmc   +1 more source

Features of Primary Hippocampal Cultures Formation on Scaffolds Based on Hyaluronic Acid Glycidyl Methacrylate [PDF]

, 2018
Tatiana A. Mishchenko, Еlena V. Mitroshina, A. I. Kuznetsova, Olesya M. Shirokova, E. V. Khaydukov, Alexander G. Savelyev, В. К. Попов, Andrei V. Zvyagin, Maria V. Vedunova   +8 more
openalex   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

No evidence from complementary data sources of a direct glutamatergic projection from the mouse anterior cingulate area to the hippocampal formation. [PDF]

Elife, 2023
Andrianova L, Yanakieva S, Margetts-Smith G, Kohli S, Brady ES, Aggleton JP, Craig MT.   +6 more
europepmc   +1 more source

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

Ventral Hippocampal Formation Is the Primary Epileptogenic Zone in a Rat Model of Temporal Lobe Epilepsy. [PDF]

J Neurosci, 2022
Buckmaster PS, Reyes B, Kahn T, Wyeth M.
europepmc   +1 more source

Tankyrase participates in neurite growth and synapse formation via poly (ADP-ribosy) lation in hippocampal neurons

, 2018
Moe Nii, Aina Uno, Takeshi Fujii, Masato Mashimo   +3 more
openalex   +2 more sources

Cell numbers, distribution, shape, and regional variation throughout the murine hippocampal formation from the adult brain Allen Reference Atlas [PDF]

, 2019
Sarojini M. Attili, Marcos F.M. Silva, Thuy-vi Nguyen, Giorgio A. Ascoli   +3 more
openalex   +1 more source