Results 11 to 20 of about 5,022,712 (233)

The hippocampal formation as a hierarchical generative model supporting generative replay and continual learning [PDF]

Progress in neurobiology, 2020
We advance a novel computational theory of the hippocampal formation as a hierarchical generative model that organizes sequential experiences, such as rodent trajectories during spatial navigation, into coherent spatiotemporal contexts.
Ivilin Peev Stoianov, Domenico Maisto, Giovanni Pezzulo   +2 more
openalex   +2 more sources

A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation

Cell, 2020
The isocortex and hippocampal formation are two major structures in the mammalian brain that play critical roles in perception, cognition, emotion and learning. Both structures contain multiple regions, for many of which the cellular composition is still
Zizhen Yao, T. Nguyen, Cindy T. J. van Velthoven, Jeff Goldy, Adriana E. Sedeño-Cortés, Fahimeh Baftizadeh, Darren Bertagnolli, Tamara Casper, Kirsten Crichton, S. Ding, Olivia Fong, E. Garren, Alexandra Glandon, James Gray, Lucas T. Graybuck, Daniel Hirschstein, Matthew Kroll, K. Lathia, Boaz P. Levi, D. McMillen, Stephanie Mok, Thanh Pham, Qingzhong Ren, Christine Rimorin, N. Shapovalova, J. Sulc, S. Sunkin, Michael Tieu, A. Torkelson, Herman Tung, Katelyn Ward, N. Dee, Kimberly A. Smith, Bosiljka Tasic, Hongkui Zeng   +34 more
semanticscholar   +1 more source

Spatial representations in macaque hippocampal formation

bioRxiv, 2020
The hippocampal formation is linked to spatial navigation but direct evidence in primates during active, unconstrained navigation is lacking. Combined with accurate behavioral tracking of eye and head, we record neurons across hippocampal regions in ...
Dun Mao, Dun Mao, Eric Avila, B. Caziot, Jean Laurens, J. Dickman, D. Angelaki, D. Angelaki, D. Angelaki   +8 more
semanticscholar   +1 more source

Fan cells in lateral entorhinal cortex directly influence medial entorhinal cortex through synaptic connections in layer 1

eLife, 2022
Standard models for spatial and episodic memory suggest that the lateral entorhinal cortex (LEC) and medial entorhinal cortex (MEC) send parallel independent inputs to the hippocampus, each carrying different types of information.
Brianna Vandrey, Jack Armstrong, Christina M Brown, Derek LF Garden, Matthew F Nolan   +4 more
doaj   +1 more source

Framing of grid cells within and beyond navigation boundaries

eLife, 2017
Grid cells represent an ideal candidate to investigate the allocentric determinants of the brain’s cognitive map. Most studies of grid cells emphasized the roles of geometric boundaries within the navigational range of the animal. Behaviors such as novel
Francesco Savelli, JD Luck, James J Knierim   +2 more
doaj   +1 more source

Hippocampal Global Remapping Can Occur without Input from the Medial Entorhinal Cortex. [PDF]

, 2018
The high storage capacity of the episodic memory system relies on distinct representations for events that are separated in time and space. The spatial component of these computations includes the formation of independent maps by hippocampal place cells ...
Boublil, Brittney L, Hales, Jena B, Leutgeb, Jill K, Leutgeb, Stefan, Schlesiger, Magdalene I   +4 more
core   +2 more sources

Intermediate levels of hippocampal activity appear optimal for associative memory formation. [PDF]

PLoS ONE, 2010
BACKGROUND: It is well established that hippocampal activity is positively related to effective associative memory formation. However, in biological systems often optimal levels of activity are contrasted by both sub- and supra-optimal levels.
Xiao Liu, Shaozheng Qin, Mark Rijpkema, Jing Luo, Guillén Fernández   +4 more
doaj   +1 more source

Electrophysiological Signatures of Spatial Boundaries in the Human Subiculum. [PDF]

, 2018
Environmental boundaries play a crucial role in spatial navigation and memory across a wide range of distantly related species. In rodents, boundary representations have been identified at the single-cell level in the subiculum and entorhinal cortex of ...
Aronson, Joshua P., Berry, Brent M., Das, Sandhitsu R., Davis, Kathryn A., Gorniak, Richard, Gross, Robert E., Jacobs, Joshua, Lee, Sang Ah, Lega, Bradley, Miller, Jonathan F., Rizzuto, Daniel S., Sharan, Ashwini, Sheth, Sameer, Sperling, Michael R., Stein, Joel M, Watrous, Andrew J., Worrell, Gregory A.   +16 more
core   +2 more sources

Chronic Stress Alters Behavior in the Forced Swim Test and Underlying Neural Activity in Animals Exposed to Alcohol Prenatally: Sex- and Time-Dependent Effects

Frontiers in Behavioral Neuroscience, 2018
Dysregulation of the hypothalamic-pituitary-adrenal (HPA) stress response has been suggested to play a role in vulnerability to stress-related disorders, such as depression.
Vivian Y. Y. Lam, Charlis Raineki, Lily E. Takeuchi, Linda Ellis, Todd S. Woodward, Todd S. Woodward, Joanne Weinberg   +6 more
doaj   +1 more source

Effect of scopolamine-based amnesia on the number of astrocytes in the rat's hippocampus [PDF]

, 2012
As neuron-astrocyte interactions play a crucial role in the adult brain, it is thought that astrocytes support learning and memory through specific mechanisms.
Azami, N.S., Jahanshahi, M., Nickmahzar, E.   +2 more
core   +1 more source