Results 31 to 40 of about 250,571 (331)
Perirhinal cortex and temporal lobe epilepsy
Frontiers in Cellular Neuroscience, 2013 The perirhinal cortex – which is interconnected with several limbic structures and is intimately involved in learning and memory - plays major roles in pathological processes such as the kindling phenomenon of epileptogenesis and the spread of limbic ...
Giuseppe eBiagini +6 more
doaj +1 more source
Hippocampal formation-inspired probabilistic generative model [PDF]
arXiv, 2021 In building artificial intelligence (AI) agents, referring to how brains function in real environments can accelerate development by reducing the design space. In this study, we propose a probabilistic generative model (PGM) for navigation in uncertain environments by integrating the neuroscientific knowledge of hippocampal formation (HF) and the ...
arxiv
Critical appraisal on mitochondrial dysfunction in Alzheimer’s disease
AGING MEDICINE, Volume 5, Issue 4, Page 272-280, December 2022., 2022 Amyloid plaques deposit on neurons in case of Alzheimer's Disease. Mitochondria play a vital role in pathogenesis of Alzheimer's Disease. Mitochondrial dysfunction can lead to formation of mPTP, alteration of complexes 1,3 and 4, deficits in bioenergetics with impaired mitochondrial biogenesis. Abstract It is widely recognized that Alzheimer's disease (
Faizan Ahmad, Punya Sachdeva
wiley +1 more source
Hippocampal lesions impair rapid learning of a continuous spatial alternation task. [PDF]
PLoS ONE, 2009 The hippocampus is essential for the formation of memories for events, but the specific features of hippocampal neural activity that support memory formation are not yet understood.
Steve M Kim, Loren M Frank
doaj +1 more source
Differential ripple propagation along the hippocampal longitudinal axis
eLife, 2023 Hippocampal ripples are highly synchronous neural events critical for memory consolidation and retrieval. A minority of strong ripples has been shown to be of particular importance in situations of increased memory demands.
Roberto De Filippo, Dietmar Schmitz
doaj +1 more source
Loss of AP-3 function affects spontaneous and evoked release at hippocampal mossy fiber synapses [PDF]
Proc Natl Acad Sci U S A (20/10/2006) sous presse, 2006 Synaptic vesicle (SV) exocytosis mediating neurotransmitter release occurs spontaneously at low intraterminal calcium concentrations and is stimulated by a rise in intracellular calcium. Exocytosis is compensated for by the reformation of vesicles at plasma membrane and endosomes.
arxiv +1 more source
Nature Communications, 2022 The mammalian hippocampal formation plays a key role in several higher brain functions. Here, the authors show that excitatory neurons in layer 6b of the mouse EC project to all sub-regions comprising the hippocampal formation and receive input from the ...
Yoav Ben-Simon +5 more
doaj +1 more source
Hippocampal Somatostatin Interneurons, Long-Term Synaptic Plasticity and Memory
Frontiers in Neural Circuits, 2021 A distinctive feature of the hippocampal structure is the diversity of inhibitory interneurons. These complex inhibitory interconnections largely contribute to the tight modulation of hippocampal circuitry, as well as to the formation and coordination of
Eve Honoré +3 more
doaj +1 more source
Hippocampal Spatial Mapping As Fast Graph Learning [PDF]
arXiv, 2021 The hippocampal formation is thought to learn spatial maps of environments, and in many models this learning process consists of forming a sensory association for each location in the environment. This is inefficient, akin to learning a large lookup table for each environment.
arxiv
Further characterization of NFIB‐associated phenotypes: Report of two new individuals
American Journal of Medical Genetics Part A, Volume 191, Issue 2, Page 540-545, February 2023., 2023 Abstract Nuclear Factor I B (NFIB) haploinsufficiency has recently been identified as a cause of intellectual disability (ID) and macrocephaly. Here we report on two new individuals carrying a microdeletion in the chromosomal region 9p23‐p22.3 containing NFIB.
Gemma Marinella +8 more
wiley +1 more source