Metabolite alterations in the hippocampus of high-functioning adult subjects with autism [PDF]
, 2009 The aim of the present study was to investigate metabolite alterations in the hippocampal formation as they relate to aggression in high-functioning adults with autism.
Isoda, Haruo +12 more
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Neurobiology of Disease, 1999 Entorhinal cortex (EC), fascia dentata (FD), hippocampus (HP), and basal ganglia (BG) were studied in Rett syndrome (RS) cases and compared with control brains and an autism case. Kluver–Barrera and Golgi methods were used. In RS most of the areas of EC,
Tatiana A. Leontovich +3 more
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Change in background context disrupts performance on visual paired comparison following hippocampal damage [PDF]
, 2009 The medial temporal lobe plays a critical role in recognition memory but, within the medial temporal lobe, the precise neural structures underlying recognition memory remain equivocal. in this study, visual paired comparison (VPC) was used to investigate
Bachevalier, J. +3 more
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Intermediate levels of hippocampal activity appear optimal for associative memory formation. [PDF]
PLoS ONE, 2010 BACKGROUND: It is well established that hippocampal activity is positively related to effective associative memory formation. However, in biological systems often optimal levels of activity are contrasted by both sub- and supra-optimal levels.
Xiao Liu +4 more
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Physical Activity Reduces Hippocampal Atrophy in Elders at Genetic Risk for Alzheimer\u27s Disease [PDF]
, 2014 We examined the impact of physical activity (PA) on longitudinal change in hippocampal volume in cognitively intact older adults at varying genetic risk for the sporadic form of Alzheimer\u27s disease (AD). Hippocampal volume was measured from structural
Durgerian, Sally +10 more
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Adult Hippocampal Neurogenesis: Regulation and Possible Functional and Clinical Correlates
Frontiers in Neuroanatomy, 2018 The formation of new neurons in the adult central nervous system (CNS) has been recognized as one of the major findings in neuroanatomical research. The hippocampal formation (HF), one of the main targets of these investigations, holds a neurogenic niche
Pedro Baptista +2 more
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Hippocampal lesions impair rapid learning of a continuous spatial alternation task. [PDF]
PLoS ONE, 2009 The hippocampus is essential for the formation of memories for events, but the specific features of hippocampal neural activity that support memory formation are not yet understood.
Steve M Kim, Loren M Frank
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Updating the lamellar hypothesis of hippocampal organization
Frontiers in Neural Circuits, 2012 In 1971, Andersen and colleagues proposed that excitatory activity in the entorhinal cortex propagates topographically to the dentate gyrus, and on through a trisynaptic circuit lying within transverse hippocampal slices or lamellae [Andersen, Bliss, and
Robert S Sloviter, Terje eLømo
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Akt1-Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration. [PDF]
, 2016 Mechanistic studies of axon growth during development are beneficial to the search for neuron-intrinsic regulators of axon regeneration. Here, we discovered that, in the developing neuron from rat, Akt signaling regulates axon growth and growth cone ...
Ahn, Jee-Yin +9 more
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Nature Communications, 2022 The mammalian hippocampal formation plays a key role in several higher brain functions. Here, the authors show that excitatory neurons in layer 6b of the mouse EC project to all sub-regions comprising the hippocampal formation and receive input from the ...
Yoav Ben-Simon +5 more
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