Results 41 to 50 of about 250,571 (331)
In search of the “I”: Neuropsychology of lateralized thinking meets Dynamic Causal Modeling
Background. Ideas about relationships between “I”, egocentric spatial orientation and the sense of bodily “Self ” date back to work by classics of philosophy and psychology. Cognitive neuroscience has provided knowledge about brain areas involved in self-
Velichkovsky B. M.+3 more
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Abstract Deletion of 17p13.3 has varying degrees of severity on brain development based on precise location and size of the deletion. The most severe phenotype is Miller–Dieker syndrome (MDS) which is characterized by lissencephaly, dysmorphic facial features, growth failure, developmental disability, and often early death.
Elizabeth K. Baker+9 more
wiley +1 more source
Computational models of neural networks can be based on a variety of different parameters. These parameters include, for example, the 3d shape of neuron layers, the neurons' spatial projection patterns, spiking dynamics and neurotransmitter systems ...
Martin ePyka+5 more
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A Putative Role for Ubiquitin-Proteasome Signaling in Estrogenic Memory Regulation
Sex steroid hormones such as 17β-estradiol (E2) are critical neuromodulators of hippocampal synaptic plasticity and hippocampus-dependent memory in both males and females.
Sarah B. Beamish, Karyn M. Frick
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According to the currently prevailing theory, hippocampal formation constructs and maintains cognitive spatial maps. Most of the experimental evidence for this theory comes from the studies on navigation in laboratory rats and mice, typically male ...
Mikhail A. Lebedev+3 more
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Hippocampal Spike-Timing Correlations Lead to Hexagonal Grid Fields [PDF]
Space is represented in the mammalian brain by the activity of hippocampal place cells as well as in their spike-timing correlations. Here we propose a theory how this temporal code is transformed to spatial firing rate patterns via spike-timing-dependent synaptic plasticity.
arxiv +1 more source
Abstract Gene variants that dysregulate signaling through the RAS‐MAPK pathway cause cardiofaciocutaneous syndrome (CFCS), a rare multi‐system disorder. Infantile epileptic spasms syndrome (IESS) and other forms of epilepsy are among the most serious complications.
Daniel L. Kenney‐Jung+14 more
wiley +1 more source
The hippocampal formation (HF) is a relevant brain structure that is involved in several neurological and psychiatric diseases. In cats, structural changes of the HF are associated with epilepsy.
Isabella Gruber+3 more
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Rabphilin-3A Drives Structural Modifications of Dendritic Spines Induced by Long-Term Potentiation
The interaction of Rabphilin-3A (Rph3A) with the NMDA receptor (NMDAR) in hippocampal neurons plays a pivotal role in the synaptic retention of this receptor.
Luca Franchini+6 more
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Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei+7 more
wiley +1 more source