Hippocampal lesions impair rapid learning of a continuous spatial alternation task. [PDF]
PLoS ONE, 2009 The hippocampus is essential for the formation of memories for events, but the specific features of hippocampal neural activity that support memory formation are not yet understood.
Steve M Kim, Loren M Frank
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The GDNF-GFRα1 complex promotes the development of hippocampal dendritic arbors and spines via NCAM [PDF]
, 2016 The formation of synaptic connections during nervous system development requires the precise control of dendrite growth and synapse formation. Although glial cell line-derived neurotrophic factor (GDNF) and its receptor GFRα1 are expressed in the ...
Alsina, Fernando Cruz +5 more
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Granule Cell Dispersion in Human Temporal Lobe Epilepsy: Proteomics investigation of neurodevelopmental migratory pathways [PDF]
, 2020 Granule cell dispersion (GCD) is a common pathological feature observed in the hippocampus of patients with Mesial Temporal Lobe Epilepsy (MTLE). Pathomechanisms underlying GCD remain to be elucidated, but one hypothesis proposes aberrant reactivation of
Al-Kaaby, B. +11 more
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Differential ripple propagation along the hippocampal longitudinal axis
eLife, 2023 Hippocampal ripples are highly synchronous neural events critical for memory consolidation and retrieval. A minority of strong ripples has been shown to be of particular importance in situations of increased memory demands.
Roberto De Filippo, Dietmar Schmitz
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Akt1-Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration. [PDF]
, 2016 Mechanistic studies of axon growth during development are beneficial to the search for neuron-intrinsic regulators of axon regeneration. Here, we discovered that, in the developing neuron from rat, Akt signaling regulates axon growth and growth cone ...
Ahn, Jee-Yin +9 more
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Nature Communications, 2022 The mammalian hippocampal formation plays a key role in several higher brain functions. Here, the authors show that excitatory neurons in layer 6b of the mouse EC project to all sub-regions comprising the hippocampal formation and receive input from the ...
Yoav Ben-Simon +5 more
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Hippocampal Somatostatin Interneurons, Long-Term Synaptic Plasticity and Memory
Frontiers in Neural Circuits, 2021 A distinctive feature of the hippocampal structure is the diversity of inhibitory interneurons. These complex inhibitory interconnections largely contribute to the tight modulation of hippocampal circuitry, as well as to the formation and coordination of
Eve Honoré +3 more
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The spectro-contextual encoding and retrieval theory of episodic memory. [PDF]
, 2014 The spectral fingerprint hypothesis, which posits that different frequencies of oscillations underlie different cognitive operations, provides one account for how interactions between brain regions support perceptual and attentive processes (Siegel etal.,
Ekstrom, Arne D, Watrous, Andrew J
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An allocentric human odometer for perceiving distances on the ground plane
eLifeWe reliably judge locations of static objects when we walk despite the retinal images of these objects moving with every step we take. Here, we showed our brains solve this optical illusion by adopting an allocentric spatial reference frame.
Liu Zhou +3 more
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Perirhinal cortex and temporal lobe epilepsy
Frontiers in Cellular Neuroscience, 2013 The perirhinal cortex – which is interconnected with several limbic structures and is intimately involved in learning and memory - plays major roles in pathological processes such as the kindling phenomenon of epileptogenesis and the spread of limbic ...
Giuseppe eBiagini +6 more
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