Results 71 to 80 of about 242,255 (327)

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez, Corinne Pettigrew, Yuxin Zhu, Claire Anderson, Guray Erus, Christos Davatzikos, Michael Miller, Abhay Moghekar, Sungtaek Oh, Chan‐Hyun Na, Marilyn Albert, Paul Worley, Anja Soldan   +12 more
wiley   +1 more source

Neuronal synapse formation induced by microglia and interleukin 10. [PDF]

PLoS ONE, 2013
Recently, it was found that microglia regulated synaptic remodeling of the developing brain, but their mechanisms have not been well understood. In this study, the action of microglia on neuronal synapse formation was investigated, and the primary target
So-Hee Lim, Eunha Park, Boram You, Youngseob Jung, A-Reum Park, Sung Goo Park, Jae-Ran Lee   +6 more
doaj   +1 more source

Gravin orchestrates protein kinase A and 2-adrenergic receptor signaling critical for synaptic plasticity and memory [PDF]

, 2012
A kinase-anchoring proteins (AKAPs) organize compartmentalized pools of protein kinase A (PKA) to enable localized signaling events within neurons. However, it is unclear which of the many expressed AKAPs in neurons target PKA to signaling complexes ...
Abel, T., Baillie, G.S., Canton, D.A., Day, J.P., Gelman, I.H., Grimes, Q., Guercio, L.A., Havekes, R., Huang, T., Luczak, V., Nie, T., Park, A.J., Scott, J.D.   +12 more
core   +2 more sources

Transducer Materials Mediated Deep Brain Stimulation in Neurological Disorders

Advanced Functional Materials, EarlyView.
This review discusses advanced transducer materials for improving deep brain stimulation (DBS) in neurological disorders. These materials respond to light, ultrasound, or magnetic fields, enabling precise, less invasive neuromodulation. Their stimulus‐responsive properties enhance neural control and adaptive therapy, paving the way for next‐generation ...
Di Zhao, Zhengyang Cao, Guangjun Zhong, Limin Shi, Junxia Xie, Jianhua Hao   +5 more
wiley   +1 more source

Consequences of Early Maternal Deprivation on Neuroinflammation and Mitochondrial Dynamics in the Central Nervous System of Male and Female Rats

Biology
Early life stress (ELS) is associated with an increased risk for neuropsychiatric disorders, and both neuroinflammation and mitochondrial dysfunction seem to be central to mental health.
Diego San Felipe, Beatriz Martín-Sánchez, Khaoula Zekri-Nechar, Marta Moya, Ricardo Llorente, Jose J. Zamorano-León, Eva M. Marco, Meritxell López-Gallardo   +7 more
doaj   +1 more source

Subregional Density of Neurons, Neurofibrillary Tangles and Amyloid Plaques in the Hippocampus of Patients With Alzheimer’s Disease

Frontiers in Neuroanatomy, 2019
A variety of anatomical alterations have been reported in the hippocampal formation of patients with Alzheimer’s Disease (AD) and these alterations have been correlated with cognitive symptoms in the early stages of the disease. Major hallmarks in AD are
Diana Furcila, Diana Furcila, Marta Domínguez-Álvaro, Javier DeFelipe, Javier DeFelipe, Javier DeFelipe, Lidia Alonso-Nanclares, Lidia Alonso-Nanclares, Lidia Alonso-Nanclares   +8 more
doaj   +1 more source

The hippocampus and cerebellum in adaptively timed learning, recognition, and movement [PDF]

, 1995
The concepts of declarative memory and procedural memory have been used to distinguish two basic types of learning. A neural network model suggests how such memory processes work together as recognition learning, reinforcement learning, and sensory-motor
Grossberg, Stephen, Merrill, John W. L.
core   +1 more source

Awake Reactivation of Prior Experiences Consolidates Memories and Biases Cognition. [PDF]

, 2019
After experiences are encoded into memory, post-encoding reactivation mechanisms have been proposed to mediate long-term memory stabilization and transformation.
Davachi, Lila, Tambini, Arielle
core   +2 more sources

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

Transneuronal Degeneration in the Spread of Alzheimer's Disease Pathology: Immunohistochemical Evidence for the Transmission of Tau Hyperphosphorylation

Neurobiology of Disease, 1997
Neurofibrillary tangles and dystrophic neurites appear to develop in a highly characteristic spatial and temporal sequence in AD. In order to examine the nature of the cellular progression we have studied the trisynaptic entorhinal, dentate gyrus, CA3/4 ...
Joseph H. Su, Gangmin Deng, Carl W. Cotman   +2 more
doaj   +1 more source