Results 71 to 80 of about 250,571 (331)

Sensory Encoding Alternates With Hippocampal Ripples across Cycles of Forebrain Spiking Cascades

Advanced Science, EarlyView.
This study reveals widespread, coordinated brain activity during passive visual stimulation in mice. Sensory coding, phase‐locked with the periodic dynamics, shows an inverse relationship to hippocampal ripples. The results suggest that periodic brain activity spurs alteration between two distinct operational modes of brain, facilitating exteroceptive ...
Yifan Yang, David A. Leopold, Jeff H. Duyn, Grayson O. Sipe, Xiao Liu   +4 more
wiley   +1 more source

Conceptual Cognitive Maps Formation with Neural Successor Networks and Word Embeddings [PDF]

arXiv, 2023
The human brain possesses the extraordinary capability to contextualize the information it receives from our environment. The entorhinal-hippocampal plays a critical role in this function, as it is deeply engaged in memory processing and constructing cognitive maps using place and grid cells.
arxiv  

Boundary Vector Cells in the Subiculum of the Hippocampal Formation [PDF]

The Journal of Neuroscience, 2009
“Boundary vector cells” were predicted to exist by computational models of the environmental inputs underlying the spatial firing patterns of hippocampal place cells (O'Keefe and Burgess, 1996; Burgess et al., 2000; Hartley et al., 2000). Here, we report the existence of cells fulfilling this description in recordings from the subiculum of freely ...
Lever, C., Burton, S., Jeewajee, A., O'Keefe, J., Burgess, N.   +4 more
openaire   +6 more sources

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

PAF‐induced inflammatory and immuno‐allergic ophthalmic diseases and their mitigation with PAF receptor antagonists: Cell and nuclear effects

BioFactors, Volume 48, Issue 6, Page 1226-1249, November/December 2022., 2022
Abstract Ocular allergies are becoming more prevalent as more airborne pollutants, irritants and microbes pervade our environment. Inflammatory and allergic mediators released by dendritic and mast cells within the conjunctiva cause allergic conjunctivitis (AC), a prevalent ocular surface disorder that affects >40% of the world's human population on a ...
Najam A. Sharif
wiley   +1 more source

Correlation Across Environments Encoded by Hippocampal Place Cells [PDF]

arXiv, 2020
The hippocampus is often attributed to episodic memory formation and storage in the mammalian brain; in particular, Alme et al. showed that hippocampal area CA3 forms statistically independent representations across a large number of environments, even if the environments share highly similar features.
arxiv  

TRAF3IP3 Induces ER Stress‐Mediated Apoptosis with Protective Autophagy to Inhibit Lung Adenocarcinoma Proliferation

Advanced Science, EarlyView.
Schematic diagram of the working model of TRAF3IP3 in the coordination of ER stress and autophagy related apoptosis in lung cancer cells. Abstract TNF receptor‐associated factor 3 interacting protein 3 (TRAF3IP3/T3JAM) exhibits dual roles in cancer progression. While upregulated in most malignancies and critical for immune regulation.
Guang Zhao, Jun Qi, Fang Li, Haotian Ma, Rui Wang, Xiuyi Yu, Yufei Wang, Sida Qin, Jie Wu, Chen Huang, Hong Ren, Boxiang Zhang   +11 more
wiley   +1 more source

Different patterns of epileptiform-like activity are generated in the sclerotic hippocampus from patients with drug-resistant temporal lobe epilepsy

Scientific Reports, 2018
Human hippocampal slice preparations from patients with temporal lobe epilepsy (TLE) associated with hippocampal sclerosis (HS) are excellent material for the characterization of epileptiform-like activity.
Selvin Z. Reyes-Garcia, Carla A. Scorza, Noemi S. Araújo, Nancy N. Ortiz-Villatoro, Anaclara Prada Jardim, Ricardo Centeno, Elza Márcia Targas Yacubian, Jean Faber, Esper A. Cavalheiro   +8 more
doaj   +1 more source

Effect of ablated hippocampal neurogenesis on the formation and extinction of contextual fear memory

Molecular Brain, 2009
Newborn neurons in the subgranular zone (SGZ) of the hippocampus incorporate into the dentate gyrus and mature. Numerous studies have focused on hippocampal neurogenesis because of its importance in learning and memory.
Ko Hyoung-Gon, Jang Deok-Jin, Son Junehee, Kwak Chuljung, Choi Jun-Hyeok, Ji Young-Hoon, Lee Yun-Sil, Son Hyeon, Kaang Bong-Kiun   +8 more
doaj   +1 more source

Synaptic potentiation facilitates memory-like attractor dynamics in cultured in vitro hippocampal networks [PDF]

Niedringhaus M, Chen X, Conant K, Dzakpasu R (2013) Synaptic Potentiation Facilitates Memory-like Attractor Dynamics in Cultured In Vitro Hippocampal Networks. PLoS ONE 8(3): e57144, 2011
Collective rhythmic dynamics from neurons is vital for cognitive functions such as memory formation but how neurons self-organize to produce such activity is not well understood. Attractor-based models have been successfully implemented as a theoretical framework for memory storage in networks of neurons.
arxiv