Results 141 to 150 of about 41,234 (255)

In severe ADNC, hippocampi with comorbid LATE-NC and hippocampal sclerosis have substantially more astrocytosis than those with LATE-NC or hippocampal sclerosis alone. [PDF]

J Neuropathol Exp Neurol, 2023
Niedowicz DM, Katsumata Y, Nelson PT.
europepmc   +1 more source

Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 4, April 2026.
The axon initial segment (AIS) is a specialized axonal domain critical for maintaining neuronal polarity, action potential initiation, and network stability. This review summarizes the necessary elements for maintaining AIS structure and plasticity, discussing crucial biological functions of AIS in neuronal signaling and the neural circuit homeostasis,
Dong‐Yan Song, Lin Yuan, Weiguo Yang, Wen Li, Jia‐Yi Li   +4 more
wiley   +1 more source

Homo sapiens, industrialisation and the environmental mismatch hypothesis

Biological Reviews, Volume 101, Issue 2, Page 580-601, April 2026.
ABSTRACT For the vast majority of the evolutionary history of Homo sapiens, a range of natural environments defined the parameters within which selection shaped human biology. Although human‐induced alterations to the terrestrial biosphere have been evident for over 10,000 years, the pace and scale of change has accelerated dramatically since the onset
Daniel P. Longman, Colin N. Shaw
wiley   +1 more source

Case Report: Anti-SOX1 antibody-associated limbic encephalitis with hippocampal sclerosis: the first autopsy case. [PDF]

Front Immunol
Izumi R, Hayashi K, Kawahara E, Miki Y, Wakabayashi K, Suzuki A, Nakaya Y, Takaku N, Sato M, Horiuchi Y, Enomoto S, Kitazaki Y, Hamano T, Kobayashi Y.   +13 more
europepmc   +1 more source

Hippocampal sclerosis

, 2008
openaire   +1 more source

Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies

Annals of Clinical and Translational Neurology, Volume 13, Issue 3, Page 547-561, March 2026.
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan, John R. Mills, Paulina Vargas, Naveen K. Paramasivan, Connie E. Lesnick, Eati Basal, Surendra Dasari, James P. Fryer, Shannon R. Hinson, Joseph Laporta, Amy Espinal, Dennis Fitzgerald, Carolina Garcia, Anna E. Morenkova, Paola Pergami, Anna Shah, Andrew Knight, Reghann LaFrance Corey, Vanda A. Lennon, Anastasia Zekeridou, Sean J. Pittock, Divyanshu Dubey, Andrew McKeon   +22 more
wiley   +1 more source

Chronic reduction of synaptic proteins in the epileptogenic lesion of patients with hippocampal sclerosis. [PDF]

Front Mol Neurosci
Oota-Ishigaki A, Suzuki N, Iijima K, Takayama Y, Kimura Y, Hattori K, Iwasaki M, Hayashi T.   +7 more
europepmc   +1 more source

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

Genome-wide association studies of TDP-43 proteinopathy and hippocampal sclerosis reveal shared genetic associations with APOE and TMEM106B. [PDF]

Alzheimers Dement
Godrich D, Pasteris J, Martin ER, Kunkle B, Naj AC, Hamilton K, Wang H, Lee WP, Dumitrescu L, Hohman TJ, Mayeux R, Larson EB, Crane PK, Keene CD, Latimer C, Mukherjee S, Kofler J, Kamboh MI, Bennett DA, Molina-Porcel L, Schellenberg G, Pericak-Vance MA, Cuccaro M, Scott WK, Rundek T, Kukull W, Montine T, Beecham GW, Alzheimer's Disease Genetics Consortium (ADGC).   +28 more
europepmc   +1 more source