Results 121 to 130 of about 883 (205)

Low‐intensity focused ultrasound neuromodulation for drug‐resistant epilepsy: A randomized, sham‐controlled crossover trial

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to evaluate the safety, feasibility, and efficacy of low‐intensity focused ultrasound (LIFU) as a noninvasive neuromodulation technique in patients with drug‐resistant epilepsy (DRE). Methods In this pilot, single‐blind, randomized sham‐controlled crossover trial, 12 patients with DRE underwent both LIFU and
Chien‐Chen Chou, Yen‐Cheng Shih, Yi‐Hsiu Chen, Po‐Tso Lin, Chun‐Fu Lin, Po‐Chun Chu, Hao‐Li Liu, Cheng‐Chia Lee, Hsiang‐Yu Yu   +8 more
wiley   +1 more source

9.4‐Tesla magnetic resonance imaging in focal epilepsy patients with high‐resolution surface‐based profiling of focal cortical dysplasias

Epilepsia, EarlyView.
Abstract Objective The detection of subtle epileptogenic lesions such as focal cortical dysplasias (FCDs) is a clinical challenge in the management of drug‐resistant focal epilepsy (DRFE). Ultra‐high‐field (UHF) magnetic resonance imaging (MRI) offers increased signal‐to‐noise ratios and spatial resolution compared to 3‐T MRI and may improve diagnostic
Cornelius Kronlage, Pascal Martin, Benjamin Bender, Gisela E. Hagberg, Jonas Bause, Joana R. A. Loureiro, Mathilde Ripart, Sophie Adler, Konrad Wagstyl, Holger Lerche, Niels K. N. Focke, Esther Kuehn   +11 more
wiley   +1 more source

Pathological hippocampal–cortical hypersynchronization disrupts memory in temporal lobe epilepsy: A multimodal intracranial electroencephalographic–functional magnetic resonance imaging study

Epilepsia, EarlyView.
Abstract Objective Memory impairment is a common comorbidity in temporal lobe epilepsy (TLE) and is thought to arise from hippocampal dysfunction and disrupted interactions within a distributed memory network involving medial temporal, frontal, and parietal cortical regions.
Ruxue Gong, Xiaolong Peng, Rebecca W. Roth, Haris Rashid, William Yun, Daniel L. Drane, Leonardo Bonilha, Lisa McTeague, Ezequiel Gleichgerrcht   +8 more
wiley   +1 more source

Abnormal KCC2 expression and function in a mouse model of epilepsy and tuberous sclerosis complex

Epilepsia, EarlyView.
Abstract Objective Drug‐resistant epilepsy is a common, severe manifestation of the genetic disorder tuberous sclerosis complex (TSC). Although significant mechanistic and therapeutic advances have been made in TSC, treatments for seizures remain largely ineffective.
Dongjun Guo, Lirong Han, Nicholas R. Rensing, Laura A. Jansen, Michael Wong   +4 more
wiley   +1 more source

Epileptic arousals: A neglected clinical entity

Epilepsia, EarlyView.
Abstract Objective Epileptic arousals (EAs) are seizures characterized solely by arousal from sleep. EAs are unrecognized in current seizure classifications. Their subtle semiology and inconsistently detectable ictal activity in scalp electroencephalography (EEG) complicate differentiation from physiological arousals (PAs). This study characterizes EAs
Lea Fisel, Nóra Pető, Sotirios Kalousios, Nicolas Zabler, Armin Brandt, Peter C. Reinacher, Dieter Riemann, Mohammad F. Khazali, Andreas Schulze‐Bonhage   +8 more
wiley   +1 more source

Correlation of polygenic risk score and clinical phenotype in patients with genetic generalized epilepsy

Epilepsia, EarlyView.
Abstract Objective The polygenic risk score (PRS) for individuals with genetic generalized epilepsy (GGE) quantifies the common risk variants in genes identified in genome‐wide association studies. We hypothesized that the phenotype of GGE patients differs based on their GGE PRS. Methods We identified participants with highest (n = 59) versus lowest (n 
Sophie von Brauchitsch, Nils Hartung, Robin A. Karge, Bobby Koeleman, Samuel F. Berkovic, Danielle M. Andrade, Francesca Bisulli, Antonio Gambardella, Renzo Guerrini, Ingrid E. Scheffer, Ingo Helbig, Wolfram S. Kunz, Holger Lerche, Hiltrud Muhle, Christian Boßelmann, Savvas S. Papacostas, Mark I. Rees, Sanjay M. Sisodiya, Pasquale Striano, Lynnette Sadleir, Yvonne Weber, Dennis Lal, Costin Leu, Philipp S. Reif, Stefan Wolking, Felix Rosenow, Karl Martin Klein, for the Epi25 Collaborative   +27 more
wiley   +1 more source

Automated segmentation of postsurgical resection cavities on magnetic resonance imaging in focal epilepsy: A Multicentre Epilepsy Lesion Detection study

Epilepsia, EarlyView.
Abstract Objective Quantitative assessment of extent of tissue resection following epilepsy surgery requires accurate delineation of the resection cavity on postoperative magnetic resonance imaging (MRI). Current methods for resection cavity masking are time‐consuming and labor‐intensive, and existing automated approaches exhibit variable segmentation ...
Jieun Seo, Mathilde Ripart, Helene Kaas, Cornelius Kronlage, Ben Sinclair, Lucy Vivash, Merran R. Courtney, Terence J. O'Brien, Siby Gopinath, Harilal Parasuram, Sedat Kandemirli, Natally Alarab, Lillian Lai, Marcus Likeman, Kai Zhang, Jiajie Mo, Georgian Ciobotaru, James Galea, Philip Sequeiros‐Peggs, Khalid Hamandi, Hua Xie, Venkata Sita Priyanka Illapani, William D. Gaillard, Nathan T. Cohen, Alexander G. Weil, Florence Henrichon‐Goulet, Kenza S. Lahlou, Aristides Hadjinicolaou, Agustín Ibáñez, Gonzalo M. Rojas‐Costa, Horst Urbach, Lara Bücheler, Marcel Heers, Adrián Valls Carbó, Rafael Toledano, Giulia Nobile, Costanza Parodi, Domenico Tortora, Alessandro Consales, Antonella Riva, Mariasavina Severino, Martin Tisdall, Felice D'Arco, Kshitij Mankad, Aswin Chari, Maria H. Eriksson, Rory J. Piper, J. Helen Cross, Torsten Baldeweg, Sofia González‐Ortiz, Jose Pariente, Nuria Bargalló, Yawu Liu, Reetta Kälviäinen, Carmen Barba, Matteo Lenge, Renzo Guerrini, Masaki Iwasaki, Daichi Sone, Hiroyuki Maki, Tomoki Imokawa, Noriko Sato, Julien Jung, Francisco Sepulveda, Daniel Mansilla, Andres Goycoolea, Ingeborg Lopez, Antonio Napolitano, Alessandro De Benedictis, Luca De Palma, Maria Camilla Rossi‐Espagnet, Nikolaos Kondylidis, Kostakis Gkiatis, Kyriakos Garganis, Joshua Pepper, Stefano Seri, John S. Duncan, Clarissa L. Yasuda, Lucas Scárdua‐Silva, Marina K. M. Alvim, Fernando Cendes, Antonio G. Gennari, Ruth O'Gorman Tuura, Georgia Ramantani, Mariam Josyula, Joel Stein, Nishant Sinha, Kate Davis, R. Edward Hogan, Luigi Maccotta, Sophie Adler, Konrad Wagstyl   +91 more
wiley   +1 more source

Brain‐wide magnetic resonance imaging analysis of neurobehavioral comorbidities in temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective In temporal lobe epilepsy (TLE), patients often present with neurobehavioral comorbidities encompassing affective and cognitive difficulties. Whereas the latter have been related to atypical connectivity of mesiotemporal and frontotemporal circuits, the brain basis of affective symptoms remains incompletely understood.
Fatemeh Fadaie, Benoit Caldairou, Boris C. Bernhardt, Andrea Bernasconi, Neda Bernasconi   +4 more
wiley   +1 more source

Spike detection in the wild: Screening of suspected temporal lobe epilepsy cases using a tailored 2‐channel wearable EEG

Epilepsia Open, EarlyView.
Abstract Objective To clinically validate the contribution of a custom‐built EEG wearable device (waEEG) compared to a full 10–20 electrode array ambulatory EEG (aEEG) for screening epilepsy cases in patients with suspected temporal lobe epilepsy (TLE) but negative routine EEGs. Methods Patients (aged 16–91 years) with clinically suspected TLE who were
Daniel Filipe Borges, Joana Isabel Soares, Daniela Dias, Helena Cordeiro, Alberto Leal   +4 more
wiley   +1 more source

Comparative assessment of artificial intelligence chatbots' performance in responding to healthcare professionals' and caregivers' questions about Dravet syndrome

Epilepsia Open, EarlyView.
Abstract Objective Artificial intelligence chatbots have been a game changer in healthcare, providing immediate, round‐the‐clock assistance. However, their accuracy across specific medical domains remains under‐evaluated. Dravet syndrome remains one of the most challenging epileptic encephalopathies, with new data continuously emerging in the ...
Joana Jesus‐Ribeiro, Eugenia Roza, Bárbara Oliveiros, Joana Barbosa Melo, Mar Carreño   +4 more
wiley   +1 more source