Results 141 to 150 of about 41,599 (208)

1 Hz Low‐Frequency Repetitive Transcranial Magnetic Stimulation Ameliorates Epilepsy by Suppressing Interferon‐γ Signaling‐Dependent Microglial Synaptic Phagocytosis in Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
In a mouse model of recurrent seizures, 1 Hz rTMS exerted neuroprotective effects by enhancing IFN‐γ‐dependent STAT2 activation in microglia and reducing CADM1/2/3 expression, thereby limiting excessive synaptic phagocytosis. Notably, co‐treatment with a neutralizing antibody against IFN‐γ abolished the 1 Hz rTMS‐induced STAT2 activation and the ...
Donghui Lin, Duan Wang, Nong Xiao
wiley   +1 more source

Identification of ferroptosis-related gene signatures in temporal lobe epilepsy with hippocampal sclerosis. [PDF]

Front Neurosci
Gao F, Li J.
europepmc   +1 more source

Integrative Drug‐Target Causal Analysis, Single‐Cell Sequencing and In‐Vivo Validation for Dissecting Molecular Mechanisms Underlying Focal Epilepsy

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Through Mendelian randomization analysis of the quantitative trait locus data, we identified that four drug targets, namely CASP1, FST, IL10RA, and SUCNR1, have significant genetic associations with the risk of focal epilepsy. This analysis provides preliminary genetic evidence for the causal mechanism by which these targets are involved in the onset ...
Huaiyu Sun, Xuewei Li, Weixuan Zhao, Hongmei Meng, Wuqiong Zhang   +4 more
wiley   +1 more source

Automated and Interpretable Detection of Hippocampal Sclerosis in Temporal Lobe Epilepsy: AID-HS. [PDF]

Ann Neurol
Ripart M, DeKraker J, Eriksson MH, Piper RJ, Gopinath S, Parasuram H, Mo J, Likeman M, Ciobotaru G, Sequeiros-Peggs P, Hamandi K, Xie H, Cohen NT, Su TY, Kochi R, Wang I, Rojas-Costa GM, Gálvez M, Parodi C, Riva A, D'Arco F, Mankad K, Clark CA, Carbó AV, Toledano R, Taylor P, Napolitano A, Rossi-Espagnet MC, Willard A, Sinclair B, Pepper J, Seri S, Devinsky O, Pardoe HR, Winston GP, Duncan JS, Yasuda CL, Scárdua-Silva L, Walger L, Rüber T, Khan AR, Baldeweg T, Adler S, Wagstyl K, MELD HS study group.   +44 more
europepmc   +1 more source

Physiology, pathology and therapeutic potential of microglial triggering receptor expressed on myeloid cells 2 signalling: A narrative update

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
TREM2hi microglia and macrophages exert distinct roles in neurological diseases. Enhancing TREM2 signalling supports pathological protein or debris clearance and mitigates inflammation in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, demyelination disorders and stroke, whereas blocking TREM2 may alleviate tauopathy and ...
Zhe Kong, Libin Shen, Daqing Ma, Jinchao Hou   +3 more
wiley   +1 more source

Girdin deficiency causes developmental and epileptic encephalopathy with hippocampal sclerosis and interneuronopathy. [PDF]

Epilepsia
Iida M, Tanaka M, Takagi T, Matsuki T, Kimura K, Shibata K, Kobayashi Y, Mizutani Y, Kuwamura H, Yamada K, Kitaura H, Kakita A, Sakakibara M, Asai N, Takahashi M, Asai M.   +15 more
europepmc   +1 more source

Ictal semiology in lateral temporal epilepsy: A systematic review and meta‐analysis

Epileptic Disorders, Volume 28, Issue 3, Page 678-689, June 2026.
Abstract Objective We performed a systematic review of the ictal semiology of the lateral temporal lobe in focal epilepsy aiming to summarize the state‐of‐the‐art anatomo‐clinical correlations in the field and help guide interpretation of ictal semiology within the framework of pre‐surgical evaluation.
Jakob I. Doerrfuss, Georg Zimmermann, Martin Holtkamp   +2 more
wiley   +1 more source

Dynamic and Static Functional Gradient in Temporal Lobe Epilepsy With Hippocampal Sclerosis Versus Healthy Controls. [PDF]

CNS Neurosci Ther
Wang K, Li J, Xie F, Liu C, Tan L, He J, Liu X, Wang G, Zhang M, Tang H, Wei D, Feng J, Huang S, Peng J, Yang Z, Long X, Xiao B, Li J, Long L.   +18 more
europepmc   +1 more source

Ictal semiology in precuneus seizures: A systematic review

Epileptic Disorders, Volume 28, Issue 3, Page 690-700, June 2026.
Abstract Objective To evaluate the ictal semiology in seizures originating in the precuneus and to help guide seizure interpretation within the framework of presurgical evaluation. Methods This systematic review followed a Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) and a Quality Assessment tool for Diagnostic Accuracy ...
Erika Ignatius, Liisa Metsähonkala, Henna Jonsson, Leena Lauronen, Päivi Nevalainen, Jukka Vanhanen, Juha Wilenius, Georg Zimmermann, Maria Peltola   +8 more
wiley   +1 more source