Results 51 to 60 of about 883 (205)

Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig, Nadav Amir, Maya Schiller, Roni Loebenstein, Johnatan Nissan, Marina Boxer, Shany Guly Gofrit, Gal Goshen, Sándor Beniczky, Nicola Maggio   +9 more
wiley   +1 more source

Clinical diagnostic features and surgical outcomes of mesial temporal lobe epilepsy

Вестник хирургии имени И.И. Грекова, 2023
Despite certain successes in the treatment of epilepsy, primarily associated with the active development of pharmacology, in 30% of cases, there is a resistant course, especially focal forms of temporal lobe epilepsy.
O. P. Subbotina, L. M. Tibekina, S. N. Tonyan   +2 more
doaj   +1 more source

Hippocampal Sclerosis in Feline Epilepsy

Brain Pathology, 2014
AbstractHippocampal sclerosis (HS) refers to loss of hippocampal neurons and astrogliosis. In temporal lobe epilepsy (TLE),HSis a key factor for pharmacoresistance, even though the mechanisms are not quite understood. While experimentalTLEmodels are available, there is lack of models reflecting the naturalHSdevelopment. Among domestic animals, cats may
Eva, Wagner, Marco, Rosati, Jessica, Molin, Ulrike, Foitzik, Andrea M, Wahle, Andrea, Fischer, Lara A, Matiasek, Sven, Reese, Thomas, Flegel, Kaspar, Matiasek   +9 more
openaire   +3 more sources

Hippocampal Malformations Do Not Necessarily Evolve into Hippocampal Sclerosis [PDF]

Epilepsia, 2005
Summary: Purpose:Hippocampal malformations have been proposed to underlie or evolve into hippocampal sclerosis, a common cause of refractory partial epilepsy. We report two patients with chronic epilepsy and developmental abnormalities of the hippocampus and cortex.
Sen, A, Thom, M, Martinian, L, Dawodu, S, Sisodiya, S   +4 more
openaire   +2 more sources

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Hippocampal Sclerosis Dementia with Tauopathy

Brain Pathology, 2003
In some elderly individuals with dementia, hippocampal sclerosis (HS) is the only remarkable autopsy finding. The cause of HS in this setting is puzzling, since known causes of HS such as seizures or global hypoxic‐ischemic episodes are rarely present. We here describe a series of HS cases that have a widespread neuronal and/or glial tauopathy.
Thomas G, Beach, Lucia, Sue, Sarah, Scott, Kathryn, Layne, Amanda, Newell, Douglas, Walker, Matthew, Baker, Naraju, Sahara, Shu-Hui, Yen, Michael, Hutton, Richard, Caselli, Charles, Adler, Donald, Connor, Marwan, Sabbagh   +13 more
openaire   +3 more sources

Thalamo‐Lesional Connectivity Signatures of Bilateral Tonic–Clonic Seizures in Focal Cortical Dysplasia‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Focal cortical dysplasia (FCD) is the most common etiology of drug‐resistant epilepsy in children. Focal to bilateral tonic–clonic seizures (FBTCS) mark a high risk of drug‐resistant epilepsy and involve thalamocortical circuitry in their generation and propagation.
Hua Xie, Xiaotong Li, Venkata Sita Priyanka Illapani, Leigh N. Sepeta, Jason Schroeder, Chima O. Oluigbo, Madison M. Berl, William D. Gaillard, Nathan T. Cohen   +8 more
wiley   +1 more source

Hippocampal sclerosis

, 2014
Hippocampal Sclerosis – Describe the common neuropathological features in relation to patients with Temporal Lobe Epilepsy Course: Epilepsy, Pain, Tumours & Infections of the Central Nervous System ...
openaire   +2 more sources

Value of extent of hippocampal resection in the surgical treatment of temporal lobe epilepsy [PDF]

Arquivos de Neuro-Psiquiatria, 2004
OBJECTIVE: Unilateral hippocampal atrophy is indicator of good surgical prognosis in patients with temporal lobe epilepsy (TLE). Some patients however do not become seizure free after surgery.
Leonardo Bonilha, Eliane Kobayashi, João Paulo V. Mattos, Donizete C. Honorato, Li M. Li, Fernando Cendes   +5 more
doaj   +1 more source

Extensive Hippocampal Demyelination in Multiple Sclerosis [PDF]

Journal of Neuropathology and Experimental Neurology, 2007
Memory impairment is especially prominent within the spectrum of cognitive deficits in multiple sclerosis (MS), and a crucial role for hippocampal pathology may therefore be expected in this disease. This study is the first to systematically assess hippocampal demyelination in MS.
Geurts, Jeroen J. G., Bö, Lars, Roosendaal, Stefan D., Hazes, Thierry, Daniëls, Richard, Barkhof, Frederik, Witter, Menno P., Huitinga, Inge, van der Valk, Paul   +8 more
openaire   +3 more sources