Results 201 to 210 of about 776,116 (376)

Targeting ROCK2 to Restore Epileptic Synaptic Networks via Mitophagy Activation: Insights from Translational Imaging of SV2A In Vivo

Advanced Science, EarlyView.
By integrating synaptic vesicle glycoprotein 2A PET imaging and transcriptomics, this study identifies Rho‐associated protein kinase 2 (ROCK2) as a critical regulator of synaptic network dysfunction in temporal lobe epilepsy. Pharmacological ROCK2 inhibition restores synaptic density and enhances mitophagy, thereby reducing seizures and neuronal damage.
Ling Xiao, Jing Wang, Bei Chen, Jinhui Yang, Fangyu Wu, Chunyao Zhou, Yifei Zhang, Zhiquan Yang, Dingyang Liu, Lei Tian, Jianhua Yu, Fei Han, Yongxiang Tang, Li Feng, Shuo Hu   +14 more
wiley   +1 more source

Amygdala-hippocampus connectivity and childhood depressive symptoms: subnuclei insights and self-concept roles. [PDF]

Transl Psychiatry
Luo L, Huang P, Chan SY, Manahan AMA, Chuah J, Ngoh ZM, Chen H, Fortier MV, Meaney MJ, Tan AP.   +9 more
europepmc   +1 more source

Postischemic synaptic physiology in area CA1 of the gerbil hippocampus studied in vitro [PDF]

, 1989
László Urbán, KH Neill, BJ Crain, J. Victor Nadler, G. Somjen   +4 more
openalex   +1 more source

Analyses of GWAS and Sub‐Threshold Loci Lead to the Discovery of Dendrite Development and Morphology Dysfunction Underlying Schizophrenia Genetic Risk

Advanced Science, EarlyView.
A cost‐effective strategy is developed analyzing sub‐threshold GWAS loci (5 × 10−8 < P ≤ 10−6), identifying 180 risk loci and 304 high‐confidence genes through combined GWAS/subGWAS analysis. This approach reveals dendrite development and morphogenesis (DDM) as a novel SCZ pathway.
Rui Chen, Benjamin Siciliano, Quan Wang, Chongchong Xu, Qiang Wei, Hai Yang, James S Sutcliffe, Yi Jiang, Ying Ji, Chunyu Liu, Feixiong Cheng, Edwin H Cook, Nancy J Cox, Xue Zhong, Zhexing Wen, Bingshan Li   +15 more
wiley   +1 more source

Differentiated Presynaptic Input to OLMɑ2 Cells Along the Hippocampal Dorsoventral Axis: Implications for Hippocampal Microcircuit Function. [PDF]

Hippocampus
Thulin A, Henriksson K, Nogueira I, Kullander K.   +3 more
europepmc   +1 more source

Episodic Memory and Beyond: The Hippocampus and Neocortex in Transformation.

Annual Review of Psychology, 2016
M. Moscovitch, R. Cabeza, G. Winocur, L. Nadel   +3 more
semanticscholar   +1 more source

The hippocampus and cue utilization [PDF]

, 1980
Gordon Winocur
openalex   +1 more source

An Automated Micro‐Immunobeads‐Based Electromagnetic Operation System (MEMOs) for Blood Testing of Alzheimer's Disease

Advanced Science, EarlyView.
This work presents an automated and accessible point‐of‐care device, MEMOs, for the detection of exosomal Aβ42 protein, a potential blood biomarker for Alzheimer’s disease. MEMOs, with its automated operation workflow, minimizes hands‐on time and maintains high sensitivity in diagnosing AD, allowing non‐specialists to conduct tests at home and offering
Xiaoxue Fan, Xinyu Ye, Jiangrui Xu, Tianjiao Mao, Ruotong Zhang, Xinyuan Zhou, Christina C. K. Au Yeung, Chang Li, Raymond Chuen‐Chung Chang, Haisong Lin, Ho Cheung Shum   +10 more
wiley   +1 more source

Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior

Cell, 2016
J. T. Gonçalves, Simon T. Schafer, F. Gage   +2 more
semanticscholar   +1 more source

Ventral Hippocampus Spikes During Sleep, Wakefulness, and Arousal in the Cat

, 1978
Kristyna M. Hartse, S. Forry Eisenhart, Bernard M. Bergmann, Allan Rechtschaffen   +3 more
openalex   +1 more source