Advanced Science, EarlyView.Higher serum UA levels are associated with reduced AD risk in epidemiological studies. UA enhances microglial phagocytic capacity primarily by restoring CD36 and TREM2 receptor recycling that is impaired by Aβ exposure. Therapeutically, UA supplementation improves cognitive function and reduces neuropathology in AD mouse model by enhancing microglial ...
De Xie +18 more
wiley +1 more source
Thyroid Hormone T4 Alleviates Traumatic Brain Injury by Enhancing Blood-Brain Barrier Integrity. [PDF]
Int J Mol SciKhandelwal M, Ying Z, Gomez-Pinilla F.
europepmc +1 more source
Ischemia-Induced Neuronal Cell Death, Calcium Accumulation, and Glial Response in the Hippocampus of the Mongolian Gerbil and Protection by Propentofylline (HWA 285) [PDF]
, 1987 Joyce A. DeLeo +4 more
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Advanced Science, EarlyView.We developed a smart MRI nanoprobe targeting BACE1 and Aβ plaques. It crosses the blood‐brain barrier. Upon encountering BACE1, the probe is cleaved, enabling T1WI imaging detection. Subsequent reaction with ONOO− induces probe aggregation, enhancing magnetic susceptibility for sensitive SWI imaging of Aβ plaques.
Minghua Li +13 more
wiley +1 more source
GLP-1 selectively enhances tonic GABA<sub>A</sub> receptor-mediated currents in mouse dentate gyrus granule cells of the ventral hippocampus. [PDF]
Front Cell NeurosciNetsyk O, Korol SV, Birnir B, Jin Z.
europepmc +1 more source
Advanced Science, EarlyView.A high‐resolution intravital imaging platform combining functional ultrasound and localization microscopy enables longitudinal, minimally invasive assessment of cerebrovascular function in aging studies. The present investigation reveals aging‐related reductions in neurovascular coupling, arteriole‐to‐venule ratio and vascular density, introducing a ...
Sharon Negri +16 more
wiley +1 more source
How the New Interacts With the Old? Hippocampal Processing During Memory Encoding of Creative Associations With Remote or Close Inherent Semantic Relatedness. [PDF]
Hum Brain MappYang J, Zhang Z, Li Z, Zhang Z, Luo J.
europepmc +1 more source
Dynorphin-A alters the excitability of pyramidal neurons of the rat hippocampus
, 1983 Donna L. Gruol +3 more
openalex +2 more sources
Correlation between oxytocin neuronal sensitivity and oxytocin receptor binding: an electrophysiological and autoradiographical study comparing rat and guinea pig hippocampus. [PDF]
, 1989 M. Raggenbass +3 more
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Advanced Science, EarlyView.Herein, guanidinium‐modified calix[5]arene (GC5AY) is developed featuring small size, positive charge, and desirable amphiphilicity, that can efficiently traverse the nasal mucosal barrier for brain drug delivery. Additionally, possessing inherent therapeutic functions, GC5AY can thus serve as a single‐molecule pleuripotent scaffold for multi‐target ...
Jian‐Mei Gao +11 more
wiley +1 more source