Results 251 to 260 of about 633,597 (336)

Buried Treasure? Overlooked and Newly Discovered Evolutionary Contributions to Human Brain Diseases

Annals of Neurology, EarlyView.
Recapitulative schema of different exploratory levels of the evolutionary impact on human neurological diseases. Clinical neuroscience focuses on the mechanisms of brain function, but this approach falls short of insights into how the central nervous system (CNS) evolved, both in health and disease.
Nico J. Diederich, Martin Brüne, John S. Allen, Nicole Bender, Emiliano Bruner, Jean‐Pierre Changeux, Corrado Cali, Olga Dolgova, Anne Grünewald, Geneviève Konopka, Peng Jin, Roger Lemon, Gilberto Levy, Pierre Magistretti, Markus J. Rantala, Kathleen S. Rockland, Roger Sullivan, Annie Swanepoel, Toshiki Uchihara, Katrin Amunts, Christopher G. Goetz   +20 more
wiley   +1 more source

A knock-in mouse model for GABRG2-related epileptic encephalopathy displays spontaneous generalized seizures and cognitive impairment. [PDF]

Cell Death Discov
Shen D, Wan J, Zhang X, Sui J, Zhan L, Zheng Y, Ni Y, Zhang Q.   +7 more
europepmc   +1 more source

Amyloid Peptide Nanofibrils Promote Efficient Neurotransmitter Oxidation and Serve as Scaffolds for Melanin Production

Angewandte Chemie, EarlyView.
Short amyloid peptides can act as efficient catalysts of neurotransmitter degradation, and libraries of short peptides can be used to identify core fragments present in larger proteins that might be linked to neurodegenerative diseases. Abstract We have shown that de novo designed peptides self‐assemble in the presence of copper to create ...
Inhye Kim, Liam R. Marshall, Shams Aaghaz, Yang Li, Ho Yee Joyce Fung, Ivan V. Korendovych   +5 more
wiley   +1 more source

Seizure evolution in a mouse model of West syndrome involves complex and time-dependent synapse remodeling, gliosis and alterations in lipid metabolism. [PDF]

PLoS Biol
Ma R, Kang M, Kim GH, Kang H, Lee S, Yang Y, Lee HJ, Choi S, Kim S, Kim S, Jun Y, Kim H, Zhang Y, Kim US, Kang HR, Kim Y, Lee Y, Chung W, Lee EJ, Park SI, Kim E, Jeon M, Hwang GS, Choi J, Jung Y, Kim JY, Kim E, Lee KJ, Han K.   +28 more
europepmc   +1 more source

Chronic effects of imipramine and lithium on 5-HT receptor subtypes in rat frontal cortex, hippocampus and choroid plexus: Quantitative receptor autoradiographic analysis.

, 1989
Tadashi Mizuta, Tomio Segawa
openalex   +1 more source

Fluoreszenzmarkierte Peptidtracer zur simultanen Aktivierung und Bildgebung des Oxytocinrezeptors

Angewandte Chemie, EarlyView.
Licht ins Dunkel: Hier präsentieren wir die Entwicklung fluoreszenzmarkierter Peptid‐Tracer, die eine gleichzeitige Visualisierung und Aktivierung des Oxytocinrezeptors – eines G‐Protein‐gekoppelten Rezeptors, der an Gesundheit und Krankheit beteiligt ist – ermöglichen.
Monika Perisic Böhm, Predrag Kalaba, Rachel S. Gormal, Maja Zupančič, Alexandra Wolf, Mia Juračić, Thomas Kremsmayr, Frédéric A. Meunier, Thierry Langer, Christian W. Gruber, Erik Keimpema, Markus Muttenthaler   +11 more
wiley   +1 more source

Cell-type-specific networks during hippocampal seizures at the micro- and macroscale. [PDF]

Brain
Wang J, Yan J, Li D, He S, Li X, Xing Y, Lai H, Gui Y, Zhang N, Huang W, Yang X.   +10 more
europepmc   +1 more source

Fluorescent Peptide Tracers for Simultaneous Oxytocin Receptor Activation and Visualization

Angewandte Chemie International Edition, EarlyView.
Illuminating the Oxytocin Receptor: Here we present the development of fluorescent peptide tracers for the simultaneous visualization and activation of the oxytocin receptor, an important G protein‐coupled receptor involved in health and disease. These tracers are powerful new tools to support various imaging and functional studies across biological ...
Monika Perisic Böhm, Predrag Kalaba, Rachel S. Gormal, Maja Zupančič, Alexandra Wolf, Mia Juračić, Thomas Kremsmayr, Frédéric A. Meunier, Thierry Langer, Christian W. Gruber, Erik Keimpema, Markus Muttenthaler   +11 more
wiley   +1 more source

Intestinal inflammation induces glymphatic remodeling, priming early neurodegenerative signals in male mice. [PDF]

Alzheimers Dement
Ciampi C, Fagiani F, Murtaj V, Comella F, Torre V, Filibian M, Andolfo A, Braccia C, Opallo N, Bottone MG, Pedrini E, Lucarini E, Bove M, Govoni S, Ghelardini C, Meli R, Trabace L, Pittaluga A, Mattace Raso G, Di Cesare Mannelli L, Lanni C.   +20 more
europepmc   +1 more source

Anatolian ground squirrel (Spermophilus xanthoprymnus) retina: Comparative expression of synaptophysin, NeuN, calbindin‐D28k, parvalbumin, glial fibrillary acidic protein, and Iba‐1 during pre‐hibernation and hibernation

The Anatomical Record, EarlyView.
Abstract Hibernation induces significant molecular and cellular adaptations in the retina to maintain function under reduced metabolic conditions. This study aimed to investigate the expression of neuronal, synaptic, and glial markers in the retina of Spermophilus xanthoprymnus during pre‐hibernation and hibernation periods using immunohistochemical ...
Mehmet Özbek, Feyzullah Beyaz, Mustafa Öztop, Harun Karaca, Ahmet Cabir, Begüm Fatma Kiryar   +5 more
wiley   +1 more source