Results 301 to 310 of about 776,116 (376)

Stereoselective Synthesis of Cannabidiol and its Unnatural Enantiomer to Evaluate Anxiolytic‐Like Properties and Memory Interactions

ChemBioChem, EarlyView.
Both (−)‐ and (+)‐cannabidiol (CBD and ent‐CBD, respectively) are synthesized via a highly diastereoselective CSA‐catalyzed Friedel–Crafts reaction. ent‐CBD exhibits anxiolytic‐like effects in aged male mice without impairing long‐term memory formation.
Marcos Accioly Jr, Kawana Rosa, Andressa G. Soliani, Suzete M. Cerutti, Cristiano Raminelli   +4 more
wiley   +1 more source

Heparan sulfate binding protein treatment ameliorates neuropathology and behavioral abnormalities in mucopolysaccharidosis IIIB mice. [PDF]

Cell Death Discov
Anzilotti S, Scarcella M, Ciampa M, Di Muraglia N, Anastasio C, Fiorentino C, Rossin F, Avallone L, Pignataro G, Pavone LM, De Pasquale V.   +10 more
europepmc   +1 more source

ARC Expands the DAAM1 Microexon‐Mediated Actin–RHOA/ROCK Interplay

Cytoskeleton, EarlyView.
ABSTRACT Actin cytoskeleton and its dynamics play a crucial role in synaptic function, influencing dendritic spines' structural and functional plasticity. Recent findings unveiled the significance of alternative splicing of a neural‐specific microexon in DAAM1 in modulating actin's role in synaptic processes.
Patryk Poliński, Marta Miret Cuesta, Manuel Irimia   +2 more
wiley   +1 more source

NSAIDS AS MODULATORS OF CATION CHANNELS: FENAMATES REPURPOSING IN CHANNELOPATHIES

ChemMedChem, Accepted Article.
Cationic ion channels are transmembrane proteins that regulate the flux of cations (potassium, sodium, and calcium) across cell membrane, playing a pivotal role in many cellular functions. Disruptions of their activity can lead to the so‐called genetic or acquired channelopathies, a heterogeneous group of diseases that affect multiple human systems ...
Paola Laghetti, Concetta Altamura, Simone Dell’Atti, Jean-François Desaphy, Ilaria Saltarella   +4 more
wiley   +1 more source

Focused ultrasound-mediated APOE4 knockdown in mouse brain. [PDF]

Alzheimers Dement
Zheng K, Tsitsos FN, Batts AJ, Ji R, Nuriel T, Konofagou EE, Leong KW.   +6 more
europepmc   +1 more source

Variation in Neurodegeneration‐Linked Brain Regions in Young Adult APOE E4 Carriers With Spina Bifida

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Objective Possible pleiotropic effects of apolipoprotein E4 (APOE E4) in individuals with congenital brain malformations are relatively unknown. Our goal was to determine if neurodegeneration‐linked brain region volumes differ significantly between E4 carriers and noncarriers in young adults with spina bifida (SB). Methods Eleven individuals ( 
Joan M. Jasien, Jacques A. Stout, Mohamad A. Mikati, Robert J. Anderson, Brittany G. Nave, Herbert E. Fuchs, Brian Smith, Alexandra Badea, Jeffrey N. Browndyke   +8 more
wiley   +1 more source

Frequency and duration of sensory flicker control transcriptional profiles in 5xFAD mice. [PDF]

APL Bioeng
Bitarafan S, Pybus AF, Rivera Moctezuma FG, Adibi M, Franklin TC, Singer AC, Wood LB.   +6 more
europepmc   +1 more source

Delayed Neuropsychiatric Syndrome Due to Unrecognized Carbon Monoxide Toxicity: A Case Report

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Introduction Carbon monoxide (CO) is a leading cause of poison‐related deaths in children and frequently results in nonspecific neurological symptoms and imaging findings. Rarely, pediatric patients develop a delayed neuropsychiatric syndrome (DNS) following a lucid interval.
Alexandria Valdrighi, Greta Peng, Andreas Rauschecker, Mary Karalius   +3 more
wiley   +1 more source

The Use of Synaptic Extracellular Myo‐Inositol to Treat Developmental and Epileptic Encephalopathy

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Objective The developmental and epileptic encephalopathies (DEE) are associated with serious and lifelong neurological conditions and risk of early mortality. Here, we describe the chronic treatment of a boy with PLCB1‐related DEE with enteral myo‐inositol supplementation as an add‐on therapy to standard antiseizure medications that had been ...
E. Naomi Vos, Didem Demirbas, Lance Rodan, Edward Yang, Sanjay P. Prabhu, Jie Chen, Xiaoping Huang, Wanshu Qi, Robin L. Haynes, Maria K. Lehtinen, Michael J. Bennett, Miao He, Phillip L. Pearl, M. Estela Rubio‐Gozalbo, Annapurna Poduri, Gerard T. Berry   +15 more
wiley   +1 more source