The impact of obesity-associated glycine deficiency on the elimination of endogenous and exogenous metabolites via the glycine conjugation pathway. [PDF]
Tan HC +5 more
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Cocaine-derived hippuric acid activates mtDNA-STING signaling in alcoholic liver disease: Implications for alcohol and cocaine co-abuse. [PDF]
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Metabolic alterations in urine among the patients with severe fever with thrombocytopenia syndrome. [PDF]
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Displacing the Burden: A Review of Protein-Bound Uremic Toxin Clearance Strategies in Chronic Kidney Disease. [PDF]
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Temporal Changes in Blood Metabolome Among Patients on Hemodialysis. [PDF]
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The recipient metabolome explains the asymmetric ovarian impact on fetal sex development after embryo transfer in cattle. [PDF]
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Stability of volatile organic compound metabolites in urine at various storage temperatures and freeze-thaw cycles for 8 months. [PDF]
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Trypsin hydrolysis of X-phenyl hippurates
Chemico-Biological Interactions, 1988The kinetics of hydrolysis of eight substituted phenyl hippurates by trypsin at pH values 6, 7 and 8 were investigated and the kinetic constants Km, kcat (kcatalysis) and kcat/Km were shown to fit the Hammett equation. The rho (rho) value obtained from the correlation of trypsin binding with this class of esters was compared with that obtained with ...
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There are some classical markers of uremic solute retention, such as serum urea and creatinine concentration. These parameters are however not always reliable, especially not in dialysis patients, so that it seemed interesting to us to undertake a multifactorial study, in an attempt to define the most suitable marker molecules in uremia.
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The stereochemistry of hippurate alkylation
Canadian Journal of Chemistry, 1998Alkylation of the hippurate esters of trans 2-(p-substituted phenyl)cyclohexanol with benzyl bromide affords phenylalanine derivatives in high chemical yield. The reaction stereoselectivity varies from 20 to >98% depending on the aromatic group in the cyclohexyl auxiliary. A model that correctly predicts the sense of the induction is proposed.
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