Results 11 to 20 of about 512 (159)

Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine α-hydroxylating monooxygenase (PHM) [PDF]

Bioorganic & Medicinal Chemistry, 2008
Peptidyl alpha-hydroxylating monooxygenase (PHM) functions in vivo towards the biosynthesis of alpha-amidated peptide hormones in mammals and insects. PHM is a potential target for the development of inhibitors as drugs for the treatment of human disease and as insecticides for the management of insect pests.
Merkler, D., Asser, A., Baumgart, L., Carballo, N., Carpenter, S., Chew, G., Cosner, C., Dusi, J., Galloway, L., Lowe, Andrew, Lowe, E., King, L., Kendig, R., Kline, P., Malka, R., Merkler, K., McIntyre, N., Romero, M., Wilcox, B., Owen, T.   +19 more
openaire   +4 more sources

Colorimetric Method for Hippuric Acid

Clinical Chemistry, 1963
Abstract Hippuric acid dissolved in pyridine producesa red-orange color upon the addition of benzenesulfonyl chloride. The color has a stable absorbance at 380 mµ. It is sensitive in microgram quantities of hippuric acid and follows the Beer-Lambert Law over a wide range of concentrations. The mechanism of the color reaction is described.
C J, UMBERGER, F F, FIORESE
openaire   +2 more sources

Hippurate hydrolysis by Legionella pneumophila [PDF]

Journal of Clinical Microbiology, 1981
Strains of Legionella pneumophila were shown to hydrolyze sodium hippurate in an overnight test system, but strains of L. bozemanii, L. micdadei, L. dumoffii, and some other organisms similar to the legionellae did not. Although only a small number of strains of legionellae other than L. pneumophila have been classified and tested, the results indicate
openaire   +2 more sources

Renal tubular secretion of o-acetylaminohippurate

, 1962
Renal tubular transport of o-acetylaminohippurate (OAAH) was investigated because of previous reports that it differed from other hippurates by not undergoing tubular secretion.
Gilbert H. Mudge, Keith Garlid, I. M. Weiner   +2 more
core   +1 more source

Disposition of 4-Methylbenzoylglycine in Rat Isolated Perfused Kidney and Effects of Hippurates on Renal Mitochondrial Metabolism

, 1998
Hippurates tend to accumulate within proximal tubule cells during renal secretion. High intracellular concentrations can alter proximal tubular function or lead to tubular toxicity.
Miek M Moons, Frans G M Russel, Rosalinde Masereeuw   +2 more
core   +1 more source

Endogenous Formation of Hippuric Acid.

Experimental Biology and Medicine, 1955
Summary1. Humans and rats receiving a purified laboratory diet excrete hippuric acid, 1 to 3 mg/kg/day. This amount appears to be formed endogenously and its excretion in the rat is not affected by fasting, by inclusion of sulfasuxidine in the diet, or by injection of phenylalanine. 2. 0.05% of the radioactivity of 3-C14-L-phenylalanine injected into a
M D, ARMSTRONG, F C, CHAO, V J, PARKER, P E, WALL   +3 more
openaire   +2 more sources

Catheter‐Associated Urinary Tract Infections in Children: An Evidence‐Informed Narrative Review of Diagnosis, Management and Prevention

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Catheter‐associated urinary tract infections (CAUTI) are a common healthcare‐associated infection in children and a major contributor to increased morbidity, prolonged hospital stays and higher healthcare costs. This narrative review uses an evidence‐informed approach highlighting recent paediatric literature (2000–2025) to provide an overview
Simon P. Paget, Robert McCusker, Suzanne Simpson, Melissa Short, Angela Berkhout   +4 more
wiley   +1 more source

Competitive inhibition of renal transport of p-aminohippurate by analogues of chlorothiazide

, 1961
Competitive inhibition of p-aminohippurate (PAH) transport by analogues of chlorothiazide has been demonstrated with slices of rabbit kidney cortex. Although analogues of low pK1 are better inhibitors of PAH transport than are analogues of higher pK1 ...
Alvin Essig
core   +1 more source

Four Haylages, One Metabonome: Defining Diet Driven Metabolic Shifts in Ponies

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Haylage is widely fed to all categories of stabled horses across Europe and New Zealand. Haylage can vary from high energy nutrient dense forage to low energy highly fibrous fodder, yet little is known about the impact different haylages have on metabolism in horses.
Meriel Moore‐Colyer, Pat Harris, Simon Daniels   +2 more
wiley   +1 more source

Factors influencing renal excretion of foreign organic acids

, 1964
Renal excretory mechanisms for 16 organic acids (mostly benzoates) were examined by standard renal clearances in the dog to establish their participation in an active secretory system, and to ascertain the factors influencing their simultaneous tubular ...
I. M. Weiner, G. H. Mudge, K. C. Blanchard   +2 more
core   +1 more source