Results 61 to 70 of about 220,074 (311)

Life‐Threatening Bradycardia in Anti‐NMDA‐Receptor Encephalitis and a Novel Use for Permanent Pacing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Pediatric anti‐NMDA receptor encephalitis (pNMDARE) is an autoantibody‐mediated disorder that can cause severe autonomic dysfunction, including symptomatic bradycardia and asystole. Dysautonomia can last for years, making it very challenging to manage.
Sarah Tucker, Abhijit Das, Andres Jimenez, Areeba Basit, Yike Jiang, Emily A. Smitherman, Heather Van Mater, Taylor Howard, Alexander J. Sandweiss, Kristen S. Fisher   +9 more
wiley   +1 more source

Dipeptidic Phosphonates: Potent Inhibitors of Pseudomonas aeruginosa Elastase B Showing Efficacy in a Murine Keratitis Model

Advanced Science
The ubiquitous opportunistic pathogen Pseudomonas aeruginosa is responsible for severe infections and notoriously known for acquiring antimicrobial resistance. Inhibiting the bacterium's extracellular elastase, LasB – a zinc‐dependent protease – presents
Alexander F. Kiefer, Christian Schütz, Colya N. Englisch, Dominik Kolling, Samira Speicher, Andreas M. Kany, Roya Shafiei, Noran A. Wadood, Ahmad Aljohmani, Niklas Wirschem, Ravindra P. Jumde, Andreas Klein, Asfandyar Sikandar, Yu‐Mi Park, Gabriela Krasteva‐Christ, Daniela Yildiz, Ahmed S. Abdelsamie, Katharina Rox, Jesko Köhnke, Rolf Müller, Markus Bischoff, Jörg Haupenthal, Anna K. H. Hirsch   +22 more
doaj   +1 more source

Styrenic Polymer Nanocomposites Based on an Oligomerically-Modified Clay with High Inorganic Content [PDF]

, 2006
Clay was modified with an oligomeric surfactant containing styrene and lauryl acrylate units along with a small amount of vinylbenzyl chloride to permit the formation of an ammonium salt so that this can be attached to a clay. The oligomerically-modified
Jiang, David D., Wang, Dongyan, Wilkie, Charles A., Zhang, Jinguo   +3 more
core   +1 more source

User-centred design of flexible hypermedia for a mobile guide: Reflections on the hyperaudio experience [PDF]

, 2005
A user-centred design approach involves end-users from the very beginning. Considering users at the early stages compels designers to think in terms of utility and usability and helps develop the system on what is actually needed.
A. Cristea, A. Kobsa, C. Callaway, C. Karagiannidis, D. Benyon, D. Lozowski Boisvert, D. Norman, D. Petrelli, D. Petrelli, Daniela Petrelli, E. Not, E. Rich, Elena Not, F. Gabrielli, G. Abowd, H. Dieterich, H.R. Hartson, J. Baus, J. Falk, J. Fink, J. Nielsen, J. Oberlander, J. Preece, J. T. Hackos, J. Vassileva, K. Cheverst, L. Ardissono, L. Calvi, M. Borun, M. Zancanaro, P. Bra De, P. Brusilovsky, P. Brusilovsky, P. Marti, R. Oppermann, W.C. Mann   +35 more
core   +1 more source

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source

Whole‐Body Pattern of Muscle Degeneration and Progression in Sarcoglycanopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize whole‐body intramuscular fat distribution pattern in patients with sarcoglycanopathies and explore correlations with disease severity, duration and age at onset. Methods Retrospective, cross‐sectional, multicentric study enrolling patients with variants in one of the four sarcoglycan genes who underwent whole‐body ...
Laura Costa‐Comellas, Mauro Monforte, Angel Sanchez‐Montañez, Penélope Romero‐Duque, Elena Pegoraro, Jordi Díaz‐Manera, Dmitry Vlodavets, Lorenzo Maggi, Marco Moscatelli, Adele D‘Amico, Montse Olivé, Jorge Alonso‐Pérez, Giacomo Comi, José Miguel Escudero‐Fernández, Gabriela S. Urcuyo, Anna Pichiecchio, Angela Berardinelli, Kristl G. Claeys, Claudio Bruno, Chiara Panicucci, Sara Bortolani, Eleonora Torchia, Enzo Ricci, Soledad Monges, Jorge A. Bevilacqua, Jorge Diaz‐Jara, Maggie C. Walter, Simone Thiele, Nicoline Løkken, John Vissing, Susana Quijano‐Roy, Robert Y. Carlier, Nicol C. Voermans, Chiara Marini‐Bettolo, Michela Guglieri, Volker Straub, Lea Leonardis, Francina Munell, David Gómez‐Andrés, Giorgio Tasca   +39 more
wiley   +1 more source

Clinically Relevant Outcome Measures in Women With Adrenoleukodystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adrenoleukodystrophy is a rare inherited peroxisomal disease caused by pathogenic variants in the ABCD1 gene located on the X chromosome. Although the most severe central nervous system and adrenal complications typically affect only men with adrenoleukodystrophy, the majority of women develop myeloneuropathy symptoms in adulthood.
Chenwei Yan, Elizabeth I. Pierpont, Amena S. Fine, Reena V. Kartha   +3 more
wiley   +1 more source

Tandem ketone reduction in pepstatin biosynthesis reveals an F420H2–dependent statine pathway

Nature Communications
Pepstatins are potent inhibitors of aspartic proteases, featuring two statine residues crucial for target binding. However, the biosynthesis of pepstatins, especially their statine substructure, remains elusive.
Jingjun Mo, Asfandyar Sikandar, Haowen Zhao, Ghader Bashiri, Liujie Huo, Martin Empting, Rolf Müller, Chengzhang Fu   +7 more
doaj   +1 more source

New myxobacteria of the Myxococcaceae clade produce angiolams with antiparasitic activities

Microbiology Spectrum
In the past century, microbial natural products have proven themselves to be substantial and fruitful sources of anti-infectives. In addition to the well-studied Actinobacteria, understudied bacterial taxa like the Gram-negative myxobacteria have ...
Sebastian Walesch, Ronald Garcia, Abdelhalim B. Mahmoud, Fabian Panter, Sophie Bollenbach, Pascal Mäser, Marcel Kaiser, Daniel Krug, Rolf Müller   +8 more
doaj   +1 more source

GlyLES: Grammar-based Parsing of Glycans from IUPAC-condensed to SMILES

Journal of Cheminformatics, 2023
Glycans are important polysaccharides on cellular surfaces that are bound to glycoproteins and glycolipids. These are one of the most common post-translational modifications of proteins in eukaryotic cells.
Roman Joeres, Daniel Bojar, Olga V. Kalinina   +2 more
doaj   +1 more source