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Nature Reviews Disease Primers, 2023
Hirschsprung disease (HSCR) is a rare congenital intestinal disease that occurs in 1 in 5,000 live births. HSCR is characterized by the absence of ganglion cells in the myenteric and submucosal plexuses of the intestine. Most patients present during the neonatal period with the first meconium passage delayed beyond 24 h, abdominal distension and ...
Louise Montalva +9 more
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Hirschsprung disease (HSCR) is a rare congenital intestinal disease that occurs in 1 in 5,000 live births. HSCR is characterized by the absence of ganglion cells in the myenteric and submucosal plexuses of the intestine. Most patients present during the neonatal period with the first meconium passage delayed beyond 24 h, abdominal distension and ...
Louise Montalva +9 more
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Update on the Pathogenesis of the Hirschsprung-Associated Enterocolitis
International Journal of Molecular Sciences, 2023 Despite the significant progress that has been made in terms of understanding the pathophysiology and risk factors of Hirschsprung-associated enterocolitis (HAEC), the morbidity rate has remained unsatisfactorily stable, and clinical management of the ...
Shaotao Tang, Kang Li
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Guidelines for the diagnosis and management of Hirschsprung-associated enterocolitis
Pediatric Surgery International, 2017 © 2017, Springer-Verlag Berlin Heidelberg. Background: Patients with Hirschsprung disease are at risk for Hirschsprung-associated enterocolitis (HAEC), an inflammatory disorder of the bowel that represents the leading cause of serious morbidity and death
Ankush Gosain +2 more
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Pediatrics In Review, 1995
In 1886, Harald Hirschsprung first described a disorder in newborns of severe constipation with dilatation and hypertrophy of the colon. No mechanical obstruction could be demonstrated, but there appeared to be an area of spasm that prevented the movement of lumen contents through the sigmoid or rectum. This disorder, termed Hirschsprung disease, later
C, Rudolph, L, Benaroch
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In 1886, Harald Hirschsprung first described a disorder in newborns of severe constipation with dilatation and hypertrophy of the colon. No mechanical obstruction could be demonstrated, but there appeared to be an area of spasm that prevented the movement of lumen contents through the sigmoid or rectum. This disorder, termed Hirschsprung disease, later
C, Rudolph, L, Benaroch
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Seminars in Pediatric Surgery, 2008
Hirschsprung disease is a relatively common condition managed by pediatric surgeons. Significant advances have been made in understanding its etiologies in the last decade, especially with the explosion of molecular genetic techniques and early diagnosis. The surgical management has progressed from a two- or three-stage procedure to a primary operation.
Ramanath N, Haricharan +1 more
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Hirschsprung disease is a relatively common condition managed by pediatric surgeons. Significant advances have been made in understanding its etiologies in the last decade, especially with the explosion of molecular genetic techniques and early diagnosis. The surgical management has progressed from a two- or three-stage procedure to a primary operation.
Ramanath N, Haricharan +1 more
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Current Opinion in Pediatrics, 2010
Hirschsprung disease is relatively common in children. Surgical techniques are available to remove the aganglionic bowel and reconstruct the intestinal tract. Despite many advances, these children may still be difficult to diagnose, and may have ongoing functional problems after surgical correction.The genetic basis and cause of Hirschsprung disease ...
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Hirschsprung disease is relatively common in children. Surgical techniques are available to remove the aganglionic bowel and reconstruct the intestinal tract. Despite many advances, these children may still be difficult to diagnose, and may have ongoing functional problems after surgical correction.The genetic basis and cause of Hirschsprung disease ...
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Surgical Clinics of North America, 1985
This review of Hirschsprung's disease reflects the authors' experience with it and outlines the current recommendations for management of its various manifestations.
L W, Martin, A M, Torres
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This review of Hirschsprung's disease reflects the authors' experience with it and outlines the current recommendations for management of its various manifestations.
L W, Martin, A M, Torres
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