Results 131 to 140 of about 46,942 (270)

Characterisation of the novel quinoline RCD405: Relaxant effects on cholinergic and histaminergic tone in human bronchi and small airways

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Increased contractility of human airway smooth muscle (hASM) is a hallmark of asthma and chronic obstructive pulmonary disease (COPD). Developing new classes of bronchodilators has proved to be challenging because of efficacy and safety concerns.
Paola Rogliani, Clive Page, Francesco Facciolo, Mia Lundblad, Luigino Calzetta   +4 more
wiley   +1 more source

Penicillin Allergy in China: Consequences of Inappropriate Skin Testing Practices and Policies

Clinical &Experimental Allergy, EarlyView.
There are significant variations in practice and implementation of penicillin skin testing within China and worldwide. Indiscriminate and ‘pre‐emptive’ skin testing practices in China significantly exacerbate penicillin allergy mislabelling, and global cooperation for advancing modern penicillin allergy diagnosis is urgently needed.
Weihong Shi, Ning Liu, Jin‐xian Huang, Hao Xiao, Juan Meng, Philip H. Li   +5 more
wiley   +1 more source

Efficacy of cimetidin in the prevention of ulcer formation in the stomach during immobilization stress [PDF]

The effect of stress on the formation of ulcers in the mucous membrane of the stomach, the increase in cyclic adenosine monophosphate level in the gastric tissues, and parietal cell structure alteration.
Dorofeyev, G. I., Gavrovskaya, L. K., Ivashkin, V. T., Litovskiy, I. A.   +3 more
core   +1 more source

Definition and classification of the histamine-release response to drugs in anaesthesia and surgery: studies in the conscious human subject [PDF]

, 1982
Doenicke, A., Grote, B., Lorenz, Wilfried, Neugebauer, E., Ohmann, C., Schöning, B.   +5 more
core   +1 more source

Approach to the Management of Gastrointestinal Manifestations in Patients With Phaeochromocytoma and Paraganglioma

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Managing gastrointestinal symptoms in patients with phaeochromocytoma and paraganglioma (PPGL) is challenging due to the risk of catecholaminergic crisis with many commonly prescribed medications, especially in functional tumours.
Monica Majumder, Cherie Chiang, Grace Kong, Michael Michael, Nirupa Sachithanandan, Emma Boehm   +5 more
wiley   +1 more source

Effects of intraduodenally applied bile salts on pancreatic secretion [PDF]

, 1993
Lehnert, Peter, Riepl, Rudolf L.
core   +1 more source

The human photosensitive epilepsy model for clinical proof‐of‐principle trials of novel antiseizure medications: 2. Analysis of drug trials and predictive value of the model

Epilepsia, EarlyView.
Abstract Clinical development of novel antiseizure medications (ASMs) would benefit from an early proof of principle (POP) model. The photosensitivity model, which uses the photoparoxysmal electroencephalographic response (PPR) as a surrogate of seizures, is currently the only human model that allows POP trials of investigational compounds after a ...
Wolfgang Löscher, Dorothée Kasteleijn‐Nolst Trenité   +1 more
wiley   +1 more source

Porphyromonas gingivalis outer membrane vesicles increase vascular permeability by inducing stress fiber formation and degrading vascular endothelial‐cadherin in endothelial cells

The FEBS Journal, Volume 292, Issue 7, Page 1696-1709, April 2025.
Porphyromonas gingivalis (Pg), a periodontal bacterium implicated in systemic diseases, release outer membrane vesicles (OMVs). Here, we show that Pg OMVs induce stress fiber formation and degrade vascular endothelial cadherin (VEc) via lysosomes and endosomes in endothelial cells, leading to hyper‐permeability.
Mana Mekata, Kaya Yoshida, Ayu Takai, Yuka Hiroshima, Ayu Ikuta, Mariko Seyama, Kayo Yoshida, Kazumi Ozaki   +7 more
wiley   +1 more source

Compound 48/80, a histamine-depleting agent, blocks the protective effect of morphine against electroconvulsive shock in mice

Brazilian Journal of Medical and Biological Research, 2000
We have shown that morphine has an anticonvulsive effect against maximal electroconvulsive shock (MES) in mice, and this effect is antagonized by histamine H1-receptor antagonists.
Karadag C.H., Dokmeci D., Dost T., Ulugol A., Dokmeci I.   +4 more
doaj  

Pitolisant alleviates brain network dysfunction and cognitive deficits in a mouse model of Alzheimer’s disease

Translational Psychiatry
Histamine H3 receptor (H3R) antagonists regulate histamine release that modulates neuronal activity and cognitive function. Although H3R is elevated in Alzheimer’s disease (AD) patients, whether H3R antagonists can rescue AD-associated neural impairments
Yang Zou, Linhan Yang, Jiahui Zhu, Jihua Fan, Hanrun Zheng, Xiang Liao, Zhiqi Yang, Kuan Zhang, Hongbo Jia, Arthur Konnerth, Yan-jiang Wang, Chunqing Zhang, Yun Zhang, Sunny C. Li, Xiaowei Chen   +14 more
doaj   +1 more source