Results 141 to 150 of about 53,301 (333)

敗血症による臓器傷害進展におけるヒスタミンの寄与 [PDF]

, 2016
富山大学・富医薬博高210号・服部瑞樹・2016/6 ...
服部 瑞樹
core   +1 more source

Targeting the noradrenergic‐metabolic axis: A new strategy for sugar‐induced depression subtypes

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Lifestyle is closely related to major depressive disorder (MDD). Given the growing focus on the impact of diet on mental health, this study examined how dietary habits affect the pathophysiology of MDD. Experimental Approach Health check‐up data were analysed. Mice received sucrose under chronic unpredictable mild stress
Takatoshi Sakata, Kazuo Kunisawa, Masaya Hasegawa, Yumiko Seto, Aoi Ogawa, Hitomi Kurahashi, Yasuko Yamamoto, Masao Takemura, Hidetoshi Matunami, Tomoya Sugai, Noriki Kutsumura, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri   +13 more
wiley   +1 more source

4-Alkynylphenyl Imidazolylpropyl Ethers as Selective Histamine H₃-Receptor Antagonists with High Oral Central Nervous System Activity

, 1998
Michael Krause, Xavier Ligneau, Holger Stark, M. Garbarg, Jean‐Charles Schwartz, Walter Schunack   +5 more
openalex   +1 more source

Protectin D1 and maresin 1 attenuate airway hyperreactivity induced by IL‐13 in human isolated small bronchi

British Journal of Pharmacology, EarlyView.
Background and Purpose Interleukin (IL)‐13 is implicated in airway hyperreactivity (AHR), a key feature of asthma. We explored the potential anti‐AHR activity of selected specialised pro‐resolving mediators (SPMs) in IL‐13‐induced AHR models, using human bronchial smooth muscle cells (BSMCs) and human isolated bronchi.
Willem Abma, Sven‐Erik Dahlén, Craig E. Wheelock, Mikael Adner, Mamdoh Al‐Amerie, Erik Sachs, Kasra Vali Jalali, Leonardo De Maria, Henric Olsson, Jesper Säfholm   +9 more
wiley   +1 more source

Low recurrence rate of ulcer after treatment with FRG-8813, a new-type histamine H2-receptor antagonist, in rats

, 1997
Hirofusa Ajioka, Hiroshi Miyake
openalex   +1 more source

Bruton tyrosine kinase (Btk) in neutrophils is indispensable for initiating and maintaining skin inflammation in a model of pemphigoid diseases

British Journal of Pharmacology, EarlyView.
Background and Purpose Bruton tyrosine kinase (Btk) is essential for B cell function. Its role in myeloid cells is less understood. Greater insights into Btk significance in myeloid cells are needed to evaluate its potential as a therapeutic target during the effector phase of antibody‐induced autoimmune diseases, where inhibiting autoantibody ...
Henning Olbrich, Paul Schilf, Sripriya Murthy, Sina Gonther, Mareike Neumann, Christoph M. Hammers, Jasper N. Pruessmann, Christian D. Sadik   +7 more
wiley   +1 more source

Dual antagonists of platelet activating factor and histamine 3. synthesis, biological activity and conformational implications of substituted N-acyl-bis-arylcycloheptapiperazines

, 1998
John J. Piwinski, J.K.Y. Wong, M J Green, James J. Kaminski, Frank Colizzo, Margaret M. Albanese, Ashit K. Ganguly, M. Motasim Billah, John C. Anthes, Robert E. West   +9 more
openalex   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

A Randomised Trial Evaluating the Effects of the TRPV1 Antagonist SB705498 on Pruritus Induced by Histamine, and Cowhage Challenge in Healthy Volunteers

, 2014
Rachel A. Gibson, Jon Robertson, Harshna Mistry, Stewart W. McCallum, Disala Fernando, Melody Wyres, Gil Yosipovitch   +6 more
openalex   +2 more sources

Definition and classification of the histamine-release response to drugs in anaesthesia and surgery: studies in the conscious human subject [PDF]

, 1982
Doenicke, A., Grote, B., Lorenz, Wilfried, Neugebauer, E., Ohmann, C., Schöning, B.   +5 more
core   +1 more source