Results 251 to 260 of about 57,473 (326)
Some of the next articles are maybe not open access.
Domain Swapping in the Human Histamine H1 Receptor
The Journal of Pharmacology and Experimental Therapeutics, 2004G-protein-coupled receptors (GPCRs) represent the largest family of receptors involved in transmembrane signaling. Although these receptors were generally believed to be monomeric entities, accumulating evidence supports the presence of GPCRs in multimeric forms.
Raymond G. Booth +7 more
openaire +4 more sources
The roles of histamine H1 receptors on cognition
Inflammation Research, 2008Histamine neurons are located exclusively in the posterior hypothalamus, from where they project diffusely to all regions of brain. Neuronal histamine has been implicated in a variety of brain functions including wakefulness, learning and memory [1].
Kazuhiko Yanai +3 more
openaire +3 more sources
Characterization of vascular histamine H1-receptors: Multiple affinity states of aortic histamine H1-receptor [PDF]
Agents and Actions, 1985 We have shown that [3H]mepyramine labels histamine H1-receptor-binding sites in bovine aortic membranes. Further characterization of H1-receptors in this tissue was done by the interaction of an unlabelled histamine receptor agonist or antagonist, with the radioantagonist [3H]mepyramine-binding sites.
openaire +2 more sources
Histamine H1- and H2-receptors in the gastrointestinal circulation [PDF]
Naunyn-Schmiedeberg's Archives of Pharmacology, 1980 Evidence for the presence of specific histamine H1- and H2-receptors in the gastrointestinal circulation was obtained using histamine, 2-methylhistamine (a specific H1-agonist), 4-methylhistamine (a specific H2-agonist), and selective H1- and H2-receptor antagonists in the anesthetized dog.
Anne Sala +2 more
openaire +2 more sources
American Review of Respiratory Disease, 2015
Terfenadine (Seldane) is a new, highly potent H1 histamine receptor antagonist that in clinically effective doses is free of side effects. Because the low potency and specificity of many H1 receptor antagonists have made it difficult to define the ...
P. Rafferty, S. Holgate
semanticscholar +1 more source
Terfenadine (Seldane) is a new, highly potent H1 histamine receptor antagonist that in clinically effective doses is free of side effects. Because the low potency and specificity of many H1 receptor antagonists have made it difficult to define the ...
P. Rafferty, S. Holgate
semanticscholar +1 more source
Histamine H1 Receptor Antagonists Facilitate Electroacupuncture Analgesia.
The American Journal of Chinese Medicine, 2018This study investigated the influence of the histamine H1 receptor antagonists, chlorpheniramine (CHL) and pyrilamine, on the analgesic effects of acupuncture in mice.
Jaung-Geng Lin +7 more
semanticscholar +1 more source
Histamine H1-receptor in the retina: Species differences
Biochemical and Biophysical Research Communications, 1988Histamine H1-receptors in membranes of the various mammalian retinas were studied by [3H]mepyramine binding assay. Specific [3H]mepyramine bindings to bovine, pig, dog and human retinas were observed with the dissociation constants (KD), 3.8 +/- 1.2 nM, 1.8 +/- 0.6 nM, 2.6 +/- 0.6 nM and 3.0 +/- 0.9 nM, respectively, which were similar to those found ...
Hiroyuki Fukui +5 more
openaire +3 more sources
Developments in histamine H1-receptor agonists
1995The story of histamine started in the early 1900’s with the fundamental investigations of Dale et al. [l–3], which recognized the remarkable physiological behavior of this biogenic amine. Scientific progress over the past decades has proved that histamine interacts with specific histamine receptors as a neurotransmitter and nearly all mammalian tissues
C. Leschke, Walter Schunack, V. Zingel
openaire +3 more sources
Histamine H1 and H2-Receptors at a Ganglionic Synapse
Nature, 1973MANY humoral agents are capable of modulating synaptic transmission in sympathetic ganglia and it has been proposed that a variety of receptors are present at the ganglionic synapse (see Haefely1). There are thus many possible modulatory mechanisms at this synapse, some of which have a dual nature, the same substance being able both to facilitate and ...
M J Brimble, D I Wallis
openaire +3 more sources