Results 91 to 100 of about 126,927 (355)

Dysregulated Choline, Methionine, and Aromatic Amino Acid Metabolism in Patients with Wilson Disease: Exploratory Metabolomic Profiling and Implications for Hepatic and Neurologic Phenotypes. [PDF]

, 2019
Wilson disease (WD) is a genetic copper overload condition characterized by hepatic and neuropsychiatric symptoms with a not well-understood pathogenesis.
Czlonkowska, Anna, Kim, Kyoungmi, Litwin, Tomasz, Mazi, Tagreed A, Medici, Valentina, Sarode, Gaurav V, Shibata, Noreene M   +6 more
core   +2 more sources

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Lysophosphatidic Acid (LPA) Induces Plasma Exudation and Histamine Release in Mice via LPA Receptors

Journal of Pharmacological Sciences, 2006
.: Lysophosphatidic acid (LPA), the simplest of the water-soluble phospholipids, can evoke various biological responses. The present study examined the activity of LPA to induce plasma exudation and histamine release in mice.
Terumasa Hashimoto, Hisayuki Ohata, Kazuo Honda   +2 more
doaj   +1 more source

Effects of methimepip and JNJ-5207852 in Wistar rats exposed to an open-field with and without object and in Balb/c mice exposed to a radial-arm maze [PDF]

, 2012
The role of the histamine H3 receptor (H3R) in anxiety is controversial, due to limitations in drug selectivity and limited validity of behavioral tests used in previous studies. In the present report, we describe two experiments.
Abuhamdah, Rushdie M., Chazot, Paul L., Ennaceur, Abdelkader, Lethbridge, Natasha L., van Rensburg, Ruan   +4 more
core   +1 more source

Association of proton pump inhibitor and histamine H2-receptor antagonists with restless legs syndrome [PDF]

, 2020
Eric J. Earley, Maria Didriksen, Bryan R. Spencer, Joseph E. Kiss, Christian Erikstrup, Ole Birger Pedersen, Erik Sørensen, Kristoffer Sølvsten Burgdorf, Steven Kleinman, Alan E. Mast, Michael P. Busch, Henrik Ullum, Grier P. Page   +12 more
openalex   +1 more source

Bioactive Phytochemical Compounds in Medicago sativa L. (Alfalfa): A Systematic Review of Biological Properties and Therapeutic Relevance in Nutraceutical and Functional Food Implications

Food Frontiers, EarlyView.
ABSTRACT Medicago sativa L. (alfalfa) harbors a remarkably diverse reservoir of bioactive secondary metabolites. Flavonoids, isoflavones, and triterpenoid saponins dominate its bioactivity landscape, driving potent antioxidant, anti‐inflammatory, antimicrobial, estrogenic, hypolipidemic, and cytotoxic actions through redox modulation, membrane ...
Parham Joolaei Ahranjani, Hamid Rashidi Nodeh, Zahra Esfandiari, Giovanna Ferrentino   +3 more
wiley   +1 more source

The dopaminergic system is able to modulate the central histamine-induced pressor effect in hemorrhage-shocked rats

Annales Academiae Medicae Silesiensis
Introduction: Histamine administered intracerebroventricularly (icv) induces a resuscitating effect in hemorrhage-shocked rats. Dopamine receptors are present in neuronal pathways involved in central cardiovascular regulation; therefore, the aim of the ...
Karolina Jasikowska, Magdalena Zając, Alessandra Ottani, Daniela Giuliani , Salvatore Guarini, Jerzy Jochem   +5 more
doaj   +1 more source

TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms [PDF]

, 2009
The mechanisms that generate itch are poorly understood at both the molecular and cellular levels despite its clinical importance. To explore the peripheral neuronal mechanisms underlying itch, we assessed the behavioral responses (scratching) produced ...
A. I. Basbaum, Andrew, Cao, Caterina, Costa, D. J. Anderson, Davidson, Endoh, G. H. Park, H. Lee, Ikoma, Johanek, Johanek, Katanosaka, LaMotte, Lee, M. I. Simon, Mackenzie, N. Imamachi, Nicholson, Paus, Reddy, S.-K. Han, Schepers, Schmelz, Shim, Simone, Sommer, Sun, Twycross, Uemura, Woo, Zeitz   +32 more
core   +2 more sources

Insect‐Derived Bioactives for Glycemic Control and Gut Health: A Review

Food Frontiers, EarlyView.
Insect‐derived bioactive compounds (e.g., peptides, polysaccharides) effectively regulate blood glucose through dual mechanisms: directly inhibiting carbohydrate‐digesting enzymes and glucose transporters, and indirectly modulating gut microbiota to enhance intestinal barrier integrity.
Chaoyi Lv, Yuanyuan Huang, Mokhtar Dabbour, Benjamin Kumah Mintah, Ronghai He, Haile Ma   +5 more
wiley   +1 more source

Role of protein kinase A in the inhibition of human mast cell histamine release by β-adrenergic receptor agonists

Allergology International, 2002
Background: Although β-adrenergic receptor agonists inhibit antigen-induced release of histamine, leukotrienes and prostaglandin D2 from human lung fragments, dispersed human lung mast cells and human skin mast cells, subcellular mechanisms for the ...
Toshinobu Kato, Masahiro Kimata, Toshikazu Tsuji, Michitaka Shichijo, Masayuki Murata, Toru Miura, Isao Serizawa, Naoki Inagaki, Hiroichi Nagai   +8 more
doaj   +1 more source