Aging Cell, EarlyView.Senolytic therapy restores neurovascular function, blood–brain barrier integrity, and cognitive performance in aged mice by targeting endothelial senescence. Findings highlight that brain microvascular endothelial cells are highly vulnerable to aging‐induced senescence, and early intervention in middle age may be the most effective strategy to prevent ...
Boglarka Csik +20 more
wiley +1 more source
Lysophosphatidic Acid (LPA) Induces Plasma Exudation and Histamine Release in Mice via LPA Receptors
Journal of Pharmacological Sciences, 2006 .: Lysophosphatidic acid (LPA), the simplest of the water-soluble phospholipids, can evoke various biological responses. The present study examined the activity of LPA to induce plasma exudation and histamine release in mice.
Terumasa Hashimoto +2 more
doaj
Production of a Human Histamine Receptor for NMR Spectroscopy in Aqueous Solutions. [PDF]
Biomolecules, 2021 Mulry E, Ray AP, Eddy MT.
europepmc +1 more source
Binding Selectivity Analysis from Alchemical Receptor Hopping and Swapping Free Energy Calculations [PDF]
arXivWe present receptor hopping and receptor swapping free energy estimation protocols based on the Alchemical Transfer Method (ATM) to model the binding selectivity of a set of ligands to two arbitrary receptors. The receptor hopping protocol, where a ligand is alchemically transferred from one receptor to another in one simulation, directly yields the ...
arxiv
Aging Cell, EarlyView.A retrospective analysis of the most effective known geroprotectors shows that they act by polypharmacological mechanisms. Using graph neural networks, we predict polypharmacological geroprotectors, validate their polypharmacological mechanisms experimentally, and show them to be exceptionally effective.
Konstantin Avchaciov +5 more
wiley +1 more source
Combined impacts of histamine receptor H1 gene polymorphisms and an environmental carcinogen on the susceptibility to and progression of oral squamous cell carcinoma. [PDF]
Aging (Albany NY), 2022 Ding YF +8 more
europepmc +1 more source
Examining the predictive validity of alcohol‐seeking following punishment‐imposed abstinence in mice
Alcohol, Clinical and Experimental Research, EarlyView.Animal models of alcohol use disorder are critical to understand the neurochemical mechanisms underlying this disorder to inform targeted medication development. However, quite often the validity of commonly used animal models remains untested. Here, we optimized a highly used model of abstinence in mice and demonstrated the predictive validity of the ...
Linh Tran +3 more
wiley +1 more source
Mycobacterium tuberculosis Utilizes Host Histamine Receptor H1 to Modulate Reactive Oxygen Species Production and Phagosome Maturation via the p38MAPK-NOX2 Axis. [PDF]
mBio, 2022 Mo S +14 more
europepmc +1 more source
Embedding Pharmacogenetics Into Clinical Practice to Improve Patient Outcomes
Annals of Human Genetics, EarlyView.ABSTRACT Pharmacogenomics, the use of germline genomic data to guide prescription to improve effective and safer medication, holds promise as a clinical intervention. To date in most health systems, there has been limited uptake of pharmacogenomic testing confined to a few single drug–gene associations.
John Henry McDermott +3 more
wiley +1 more source
Mast cell carboxypeptidase A, a secretory granule component [PDF]
, 2005 Mast cells are highly granulated cells of the immune system that upon stimulation release a number of inflammatory mediators including heparin and/or chondroitin sulphate (CS) proteoglycan (PG) and various heparin-binding proteases such as tryptase ...
Henningsson, Frida
core