Results 181 to 190 of about 126,927 (355)

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Correspondence to ‘Hypersensitivity Reactions to Human Albumin—A Case Series and Diagnostic Algorithm’

Allergy, EarlyView.
Juliette Charpy, Mathilde Seydoux, Antoine Giraudon, Julien Bonnac, Maxime Dubois, Maryline Bordes‐Demolis, Christelle Pellerin, Julien Goret   +7 more
wiley   +1 more source

Critical role of the mast cell/tryptase/PAR2 axis in anastrozole‐induced pain

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Anastrozole, an aromatase inhibitor, is used to treat postmenopausal women with hormone receptor‐positive breast cancer, but also induces musculoskeletal pain and can lead to therapeutic regimen suspension. Aromatase inhibitors promote the release of pro‐inflammatory substances from sensitised nerve fibres, which might ...
Maria Fernanda Pessano Fialho, Raquel Tonello, Evelyne Silva Brum, Gabriela Becker, Nigel W. Bunnett, Sara Marchesan Oliveira   +5 more
wiley   +1 more source

Dual-Histamine Receptor Blockade with Cetirizine - Famotidine Reduces Pulmonary Symptoms in COVID-19 Patients [PDF]

Pulm Pharmacol Ther, 2020
Hogan RB, Hogan RB, Cannon T, Rappai M, Studdard J, Paul D, Dooley TP.   +6 more
europepmc   +2 more sources

Pharmacological Properties of ABT-239 [4-(2-{2-[(2 R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: I. Potent and Selective Histamine H3 Receptor Antagonist with Drug-Like Properties

, 2005
Timothy A. Esbenshade, Gerard B. Fox, Kathleen M. Krueger, Thomas R. Miller, Chae Hee Kang, Lynne Denny, David G. Witte, Betty Yao, Liping Pan, Jill M. Wetter, Kennan C. Marsh, Youssef L. Bennani, Marlon Cowart, James P. Sullivan, Arthur A. Hancock   +14 more
openalex   +1 more source

Histamine response and local cooling in the human skin: involvement of H₁‐ and H₂‐receptors [PDF]

, 1999
M. Großmann, M. J. Jamieson, Wilhelm Kirch   +2 more
openalex   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

In vitro effects of histamine receptor 1 antagonists on proliferation and histamine release in canine neoplastic mast cells. [PDF]

Vet Med Sci, 2021
Gamperl S, Stefanzl G, Willmann M, Valent P, Hadzijusufovic E.   +4 more
europepmc   +1 more source

Roles of Phosphorylation-dependent and -independent Mechanisms in the Regulation of Histamine H2 Receptor by G Protein-coupled Receptor Kinase 2 [PDF]

, 2011
Natalia Fernández, Federico L. Gottardo, María Natalia Alonso, Federico Monczor, Carina Shayo, Carlos Davio   +5 more
openalex   +1 more source

Targeting the noradrenergic‐metabolic axis: A new strategy for sugar‐induced depression subtypes

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Lifestyle is closely related to major depressive disorder (MDD). Given the growing focus on the impact of diet on mental health, this study examined how dietary habits affect the pathophysiology of MDD. Experimental Approach Health check‐up data were analysed. Mice received sucrose under chronic unpredictable mild stress
Takatoshi Sakata, Kazuo Kunisawa, Masaya Hasegawa, Yumiko Seto, Aoi Ogawa, Hitomi Kurahashi, Yasuko Yamamoto, Masao Takemura, Hidetoshi Matunami, Tomoya Sugai, Noriki Kutsumura, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri   +13 more
wiley   +1 more source