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Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU‐EMRE Assembly

Advanced Science, Volume 12, Issue 17, May 8, 2025.
Berberine, a safe and FDA‐approved drug, is identified as a novel mitochondrial calcium uniporter (MCU) inhibitor. By disrupting MCU‐EMRE interaction, Berberine prevents mitochondrial calcium overload and protects against ischemia/reperfusion injury, offering a promising therapeutic strategy for diseases linked to mitochondrial calcium dysregulation ...
Haixin Zhao, Siqi Chen, Nian Cao, Wenjun Wu, Guangqin Liu, Jun Gao, Jiayi Chen, Ting Li, Dingyi Lu, Lingmin Zeng, Haizhen Zhu, Weina Zhang, Qing Xia, Teng Li, Tao Zhou, Xue‐Min Zhang, Ai‐Ling Li, Xin Pan   +17 more
wiley   +1 more source

PRL2 negatively regulates FcεRI mediated activation of mast cells. [PDF]

Cell Death Dis
Guo X, Lei Y, Xu Y, Du X, Lin L, Luo Y, Xi Y, Guo Y, Niu X, Wang Z, Chen G.   +10 more
europepmc   +1 more source

Caffeine promotes glutamate and histamine release in the posterior hypothalamus.

Am J Physiol Regul Integr Comp Physiol, 2014
John J, Kodama T, Siegel JM.
europepmc   +1 more source

Modafinil Ameliorated Fibromyalgia Syndrome in Rats by Modulating Mast Cells and Microglia Activation Through Dopamine/Substance P/MRGPRX/Histamine and PI3K/p-Akt/NF-κB Signaling Pathways. [PDF]

J Neuroimmune Pharmacol
Kamal MM, Essam RM, Abdelkader NF, Zaki HF.   +3 more
europepmc   +1 more source

Mouse Adrenal Macrophages Are Associated with Pre- and Postsynaptic Neuronal Elements and Respond to Multiple Neuromodulators. [PDF]

eNeuro
Whim MD.
europepmc   +1 more source

Deciphering Histamine Pathway Networks in the Human Brain: A Multimodal Approach to Cognition and Psychiatric Disorders

Martins D, Veronese M, Wamelen Dv, Shan L, Howes O, Hampshire A, Turkheimer F, Williams SC.   +7 more
europepmc   +1 more source

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Histamine releasing factors

Clinical & Experimental Allergy, 1991
Histamine-releasing factors (HRF) are cell-derived products which cause histamine release from basophils and/or mast cells. We have isolated HRF from human mononuclear cells and platelets and have purified 3 molecular species having molecular weights of 8–10, 15–17 and 35–41 kilodaltons (kDa).
M L Baeza, Allen P. Kaplan, Piotr Kuna, Sesha Reddigari   +3 more
openaire   +5 more sources

Histamine release in man [PDF]

Agents and Actions, 1975
(1) Histamine release in man could be demonstrated using the fluorometric histamine assay in plasma as a reliable test. (2) Histamine release in animals may be relevant in some cases for human subjects, as shown for anaesthetic drugs and plasma substitutes on gelatin basis.
openaire   +4 more sources