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Development of a microassay for histamine release
Clinical & Experimental Allergy, 1987SummaryA microassay has been developed to measure histamine release from both washed human leucocytes and whole blood, in which blood samples can be diluted down to 1:20 without affecting their sensitivity to antigen. The sensitivity and reproducibility of the single isotope histamine radioenzymatic assay [REA] was compared to the conventional ...
D. M. Kemeny +2 more
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Inhibition of Histamine Release in Anaphylaxis
Nature, 1955ALTHOUGH the effects of anaphylaxis and chemical histamine releasers are similar and mainly attributable to histamine release, the mechanism by which the release occurs in the two cases is fundamentally different. We have found that lack of oxygen and also inhibitors of oxidative and glycolytic metabolism have a powerful inhibitory action on the ...
J. L. Mongar, H. O. Schild
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Leucocyte Histamine Release in Migraine
Headache: The Journal of Head and Face Pain, 1980SYNOPSISAlthough histamine has been suggested as a possible vasoactive mediator in the pathogenesis of migraine, the mechanism of histamine release and its exact role in the pathophysiology of migraine is unclear. The spontaneous release of histamine from plasma‐free leucocyte suspensions was examined in 9 patients with 5 types of migraine.
Andrew W. Zimmerman +3 more
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Histamine Release by Air Pollutants
Archives of Environmental Health: An International Journal, 1969The release of histamine in guinea pig lungs after inhalation of 1 to 50 ppM SO/sub 2/, 10 ppM NO/sub 2/, or cigarette smoke was minimal in terms of the amount released spontaneously. Histamine release was not significant until concentrations caused severe lung damage.
Douglas Js, Dennis Mw, Ridgway P
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Histamine Release in Anesthesia and Surgery
Allergy and Asthma Proceedings, 1985Histamine release can occur in response to anaphylactic or chemically mediated anaphylactoid reactions during general anesthesia. Narcotics and muscle relaxants have been demonstrated both in vitro and in vivo to cause significant histamine release. This histamine release appears to be directly related to changes in the cardiovascular system that are ...
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Histamine releasing factor is not an interferon
Agents and Actions, 1986The speculation that human histamine releasing factor (HRF) - a lymphokine that releases histamine from human tissues, might be the same as gamma-interferon was investigated. The speculation arose from the fact that HRF and gamma-interferons are both lymphokines and have both been reported to affect histamine release from human basophils.
El-Sayed K. Assem, I. C. Ezeamuzie
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Release of histamine by substance P
Naunyn-Schmiedeberg's Archives of Pharmacology, 19811. The basic peptide substance P causes histamine release from peritoneal mast cells of the rat in vitro whereas the closely related neutral peptides eledoisin and physalaemin do not. 2. Infusion of substance P (7.4 nmol min-1), but not of eledoisin (8.4 nmol min-1) or physalaemin (7.9 nmol min-1), into the rat hindquarter preparation caused a more ...
F. Erjavec +6 more
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Histamine release by gastric stimulants
Nature, 1975IT is a matter of debate whether histamine in the gastric mucosa acts as a local chemical mediator for other gastric stimulants1–5, and the isolated bullfrog mucosa provides a convenient model for investigation of the question. The preparation responds to gastric stimulants such as pentagastrin, acetylcholine and histamine; the secretory rate can be ...
Patangi K. Rangachari +1 more
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Isotope assay of histamine release
Biochemical Medicine, 1974Abstract The single isotopic enzymatic histamine assay system has been adopted for the studying of the release of histamine from sensitized human leukocytes when challenged with the appropriate allergen. It is a simple, rapid, sensitive, and reproducible method based on the use of the enzyme histamine N-methyltransferase and the high specific ...
Gary S. Carlson +3 more
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Muscle relaxants and histamine release
Acta Anaesthesiologica Scandinavica, 1995Many anaesthetic drugs and adjuvants can cause the release of histamine by chemical (anaphylactoid) or immunologic (anaphylactic) mechanisms. While both types of reactions can be clinically indistinguishable, they are mechanistically different. In anaphylactoid reactions, only preformed mediators are released, of which histamine may be the most ...
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