Results 101 to 110 of about 87,659 (287)

Studies on the release of neutrophil extracellular traps and IFN-γ as part of the innate immune response to Aspergillus fumigatus and on the fungal stress response via the hybrid sensor kinase TcsC [PDF]

, 2012
Aspergillus fumigatus is a saprophytic mold that naturally inhabits the soil. Asexual reproduction yields hardy conidia that circulate in the air and are inhaled daily by humans.
McCormick, Allison
core  

Genetic and biochemical dissection of a HisKA domain identifies residues required exclusively for kinase and phosphatase activities.

PLoS Genetics, 2012
Two-component signal transduction systems, composed of histidine kinases (HK) and response regulators (RR), allow bacteria to respond to diverse environmental stimuli.
Jonathan W Willett, John R Kirby
doaj   +1 more source

Histidine Phosphorylation: Protein Kinases and Phosphatases

International Journal of Molecular Sciences
Phosphohistidine (pHis) is a reversible protein post-translational modification (PTM) that is currently poorly understood. The P-N bond in pHis is heat and acid-sensitive, making it more challenging to study than the canonical phosphoamino acids pSer, pThr, and pTyr. As advancements in the development of tools to study pHis have been made, the roles of
Jia Ning, Margaux Sala, Jeffrey Reina, Rajasree Kalagiri, Tony Hunter, Brandon S. McCullough   +5 more
openaire   +2 more sources

Histidine Supplementation Stabilizes Hearing and Vision and Improves Growth in HARS1‐Related Autosomal Recessive Disorder Associated With Usher‐Like Symptoms

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal recessive HARS1‐related disorder (originally described as Usher syndrome type 3B) caused by a homozygous Y454S variant in the histidyl‐tRNA synthetase gene (HARS1) is characterized by progressive sensorineural hearing and vision loss and respiratory deterioration with risk for sudden death following febrile illnesses.
Victoria Mok Siu, Rosan Kenana, Rana Chakrabarti, Sarah D. P. Wilhelm, Joseph Andrews, Susan J. Leat, Christina Parker, Michael Miller, Leslie A. Nangle, Wendy McCaul, Ashfia Chowdhury, Natalie Hutchings, Ryan A. Adams, Lauren Guy, Mandy Rhody, Verena Juncal, Marisa I. Mendes, Desiree E. C. Smith, Gajja S. Salomons, Angelica A. Moresco, Daphne L. McCulloch, D. Holmes Morton, Ilka U. Heinemann, C. Anthony Rupar   +23 more
wiley   +1 more source

Reversible and specific extracellular antagonism of receptor-histidine kinase signaling [PDF]

, 2002
Staphylococcal pathogenesis is regulated by a two-component quorum-sensing system, agr, activated by a self-coded autoinducing peptide (AIP). The agr system is widely divergent and is unique in that variant AIPs cross-inhibit agr activation in ...
Novick, Richard P., Muir, Tom W., Christopoulos, Arthur, Wright, Jesse S., Lyon, Gholson J.   +4 more
core   +1 more source

Conformational sampling of CpxA: Connecting HAMP motions to the histidine kinase function.

PLoS ONE, 2018
In the histidine kinase family, the HAMP and DHp domains are considered to play an important role into the transmission of signal arising from environmental conditions to the auto-phosphorylation site and to the binding site of response regulator ...
Nathalie Duclert-Savatier, Guillaume Bouvier, Michael Nilges, Thérèse E Malliavin   +3 more
doaj   +1 more source

Supplementary material to "Structural and functional analysis of the Escherichia coli acid-sensing histidine kinase, EvgS" [PDF]

, 2017
Supplementary material to "Structural and functional analysis of the Escherichia coli acid-sensing histidine kinase ...
Lund, Peter
core   +1 more source

Expression and characterization of the integral membrane domain of bacterial histidine kinase SCO3062 for structural studies [PDF]

, 2008
Bacterial histidine kinases play an important role in the response to external stimuli. Structural studies of the histidine kinase transmembrane domain are challenging due to difficulties in protein expression and sample preparation.
Myung Hee Kim, C Cheong, K J Yeo, Y H Jeon, Su Nam Gwak, H J Kim   +5 more
core   +1 more source

A Bacterial Receptor PcrK Senses the Plant Hormone Cytokinin to Promote Adaptation to Oxidative Stress

Cell Reports, 2017
Summary: Recognition of the host plant is a prerequisite for infection by pathogenic bacteria. However, how bacterial cells sense plant-derived stimuli, especially chemicals that function in regulating plant development, remains completely unknown. Here,
Fang-Fang Wang, Shou-Ting Cheng, Yao Wu, Bao-Zhen Ren, Wei Qian   +4 more
doaj   +1 more source

The kinetic analysis of the enzyme reaction catalyzed by the globine coupled histidine kinase [PDF]

, 2014
Two-component signal systems serve as basic stimulus-response coupling mechanism to allow organisms (predominantly bacteria) to sense and respond to changes in many environmental conditions.
Fojtíková, Veronika
core