Results 111 to 120 of about 87,659 (287)

Activity-Based Probe for Histidine Kinase Signaling [PDF]

, 2016
Bacterial two-component systems (TCSs) are signaling pathways composed of two proteins: a histidine kinase (HK) and a response regulator (RR). Upon stimulation, the HK autophosphorylates at a conserved histidine.
Samson Francis (1371465), Kaelyn E. Wilke (1371468), Erin E. Carlson (1371462)   +2 more
core   +1 more source

Tissue‐Specific and Spatially Dependent Metabolic Signatures Perturbed by Injury in Male and Female Mice

Arthritis &Rheumatology, EarlyView.
Objective Osteoarthritis, the leading cause of disability worldwide, disproportionately affects women, yet sex remains an overlooked determinant. This disparity stems from sex‐specific differences in injury susceptibility—a major risk factor for disease.
Hope D. Welhaven, Avery H. Welfley, Priyanka P. Brahmachary, Mark Greenwood, Donald F. Smith, Brian Bothner, Ronald K. June   +6 more
wiley   +1 more source

Short Protein Evolution Stories: Illuminating Aspects of MempromCC and Histidine Kinase Evolution [PDF]

, 2018
Sequence-based bioinformatic analysis has long been a driving force of evolutionary studies, while experimental approaches offer new insights through mutagenesis, in vivo and in vitro evolution.
Karamichali, I. ; https://orcid.org/
core   +1 more source

Peripheral Blood DNA Methylation Changes Precede Lymphoma Diagnosis in Primary Sjögren's Disease

Arthritis &Rheumatology, EarlyView.
Objective Primary Sjögren's disease (SjD) is a systemic autoimmune disease associated with an increased risk of lymphoma. The molecular mechanisms underlying lymphomagenesis remain poorly understood, and sensitive biomarkers for early identification of patients at high risk of developing lymphoma are lacking.
Hanna Lidberg, Cecilia Fugmann, Juliana Imgenberg‐Kreuz   +2 more
wiley   +1 more source

Enhanced strategies for cuproptosis‐like death in bacterial infection treatment

BMEMat, EarlyView.
This review summarizes and examines the molecular mechanisms underlying cuproptosis‐like death. Furthermore, multi‐strategy efficacy enhancement and potential enhancement approaches are analyzed. Abstract Copper, a classical antibacterial metal, has long been of interest and widely used in medical and public health applications.
Wenqi Wang, Bolong Xu, Ruiyuan Zhu, Hengshuo Gui, Tian Xia, Shaokai Liu, Huiyu Liu, Xianwen Wang   +7 more
wiley   +1 more source

Functional characterization of AtoS-histidine protein kinase in E-coli [PDF]

, 2008
Journal URL: http://www.springer.at/amino_acidsAbstractAtoS is the membrane signal-transducing histidine kinase (HK) that together with the response regulator AtoC plays a pivotal role in the transcriptional regulation of atoDAEB operon in Escherichia ...
Panagiotidis, C. A., Kasemian, L. D., Filippou, P. S., Kyriakidis, D.A.   +3 more
core  

Ligand-Induced Asymmetry in Histidine Sensor Kinase Complex Regulates Quorum Sensing [PDF]

, 2006
SummaryBacteria sense their environment using receptors of the histidine sensor kinase family, but how kinase activity is regulated by ligand binding is not well understood.
Bassler, Bonnie L., Hughson, Frederick M., Federle, Michael J., Pompeani, Audra J., Kelly, Robert C., Swem, Danielle L., Neiditch, Matthew B., Jeffrey, Philip D.   +7 more
core   +1 more source

Identification of an Important Orphan Histidine Kinase for the Initiation of Sporulation and Enterotoxin Production by Clostridium perfringens Type F Strain SM101

mBio, 2019
Clostridium perfringens type F strains cause a common human foodborne illness and many cases of nonfoodborne human gastrointestinal diseases. Sporulation plays two critical roles during type F enteric disease.
John C. Freedman, Jihong Li, Eric Mi, Bruce A. McClane   +3 more
doaj   +1 more source

Dual Regulatory Functions of Classical Zinc Finger Clusters from Myeloid Zinc Finger‐1

Chemistry – A European Journal, EarlyView.
The classical zinc finger (ZF) protein MZF1 uses two ZF clusters to achieve metal‐dependent and gene‐specific promoter recognition. The differential redox stability and modular utilization of the two ZF clusters enable MZF1 to regulate cerebrovascular, neuronal, and cancer‐related transcriptional programs.
Yunha Hwang, Yerim Park, Nohwan Park, Heeju Noh, Hyun Goo Kang, Seung Jae Lee   +5 more
wiley   +1 more source

Biochemical studies of a ser/thr kinase, ser/thr phosphatase and a histidine kinase from Pseudomonas aeruginosa. [PDF]

, 2000
Biochemical studies of a ser/thr kinase, ser/thr phosphatase and a histidine kinase from Pseudomonas ...
Subhendu. Mukhopadhyay (7976879)
core