Results 231 to 240 of about 87,659 (287)

Eyes Toward the Clinic: Selective Inhibition and Degradation Approaches to Bromodomain‐Containing Proteins

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
The function of bromodomain‐containing proteins in regulating gene transcription is reviewed here, including the development of chemical probes and targeted protein degradation modalities (e.g., PROTACs). This extends to clinical efforts targeting the BET bromodomain‐containing proteins. Challenges of selectivity, future prospects, and the differential
Cole R. Scholtz, William C. K. Pomerantz
wiley   +1 more source

Genetics of conditional extended mycelial cell viability of Streptomyces minutiscleroticus in deep starvation phase implicates the involvement of (p)ppGpp, clpX, and a histidine kinase sasA. [PDF]

Front Microbiol
Chatupale V, Pohnerkar J.
europepmc   +1 more source

Development of Quorum Sensing Modulators of Streptococcus constellatus

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Using a rational design approach, novel Streptococcus constellatus competence stimulating peptide (CSP) analogs with enhanced potencies were developed. These newly identified CSP analogs provide a rational framework for the development of CSP‐based quorum sensing modulators with translational potential in attenuating virulence processes in this ...
Keely M. Rodriguez, Daniel N. Elliott, Ella R. Lemieux, Oscar S. Liu, Yftah Tal‐Gan   +4 more
wiley   +1 more source

Cross-Phosphorylation between AgrC Histidine Kinase and the Noncognate Response Regulator Lmo1172 in Listeria monocytogenes under Benzalkonium Chloride Stress. [PDF]

Microorganisms
Yu T, Jiang X, Xu X, Xu P, Qiu S, Yin J, Hamilton DP, Jiang X.   +7 more
europepmc   +1 more source

Membrane‐Associated Biomolecules for Synthetic Cell Signalling

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Membrane‐associated proteins and nucleic acids are transforming synthetic cell communication, unlocking applications in biosensing, therapeutics, and tissue engineering. This review explores how these biomolecules enable complementary strategies for cell tethering, vesicle generation and fusion, signal transmission, and signal transduction.
Chelsea Dack, Bingkun Li, Charlie Newell, Michael J. Booth   +3 more
wiley   +1 more source

The N-terminus of the <i>Aspergillus fumigatus</i> group III hybrid histidine kinase TcsC is essential for its physiological activity and targets the protein to the nucleus. [PDF]

mBio
Vincek A, Wolf A, Thomas A, Ebel F, Schruefer S.   +4 more
europepmc   +1 more source

Overexpressing the <i>cpr1953</i> Orphan Histidine Kinase Gene in the Absence of <i>cpr1954</i> Orphan Histidine Kinase Gene Expression, or Vice Versa, Is Sufficient to Obtain Significant Sporulation and Strong Production of <i>Clostridium perfringens</i> Enterotoxin or Spo0A by <i>Clostridium perfringens</i> Type F Strain SM101. [PDF]

Toxins (Basel)
Mehdizadeh Gohari I, Gonzales JL, Uzal FA, McClane BA.   +3 more
europepmc   +1 more source

Atomic insights into the signaling landscape of E. coli PhoQ Histidine Kinase from Molecular Dynamics simulations

Lazaridi S, Yuan J, Lemmin T.
europepmc   +1 more source

Cyclic di-GMP mediates a histidine kinase/phosphatase switch by noncovalent domain cross-linking [PDF]

Science Advances, 2016
Histidine kinases are key components of regulatory networks in bacteria. Although many of these enzymes are bifunctional, mediating both phosphorylation and dephosphorylation of downstream targets, the molecular details of this central regulatory switch ...
Tilman Schirmer, Urs Jenal, Shogo Ozaki   +2 more
exaly   +3 more sources