Results 211 to 220 of about 87,659 (287)
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.In cardiac cells, Plin5/AMPK regulate lipid homeostasis; excess CD36‐mediated uptake drives lipotoxicity, mitochondrial dysfunction, and CVDs (e.g., heart failure). Biomarkers (ApoB/ApoA‐1) and therapies (SGLT2 inhibitors) target this cascade. ABSTRACT Cardiac lipid metabolism is fundamental to myocardial energy homeostasis, with fatty acid oxidation ...
Peiyun Xie +3 more
wiley +1 more source
Histidine kinase-mediated cross-regulation of the vancomycin-resistance operon in Clostridioides difficile. [PDF]
Mol MicrobiolBelitsky BR.
europepmc +1 more source
Amino Acid and Lipid Metabolism in Cancer: Mechanisms and Therapeutic Opportunities
MedComm, Volume 7, Issue 8, August 2026.Amino Acid and lipid metabolism in cancer: (A) Regulation of Amino acid transportation and metabolism in cancer. (B) The core organization of lipid metabolic reprogramming in cancer and their functional consequences. ABSTRACT Metabolic reprogramming is a defining feature of cancer and a major contributor to immune escape.
Zixu Wang +4 more
wiley +1 more source
Protein Science, Volume 35, Issue 8, August 2026.Abstract The spatial and energetic encoding of allosteric regulatory sites remains a major challenge in structural biology, frequently representing a “blind spot” for sequence‐based artificial intelligence (AI) models. We present a protein language model (PLM)‐guided approach complemented by the energy landscape frustration analysis as a dual‐stream ...
Will Gatlin +8 more
wiley +1 more source
A Homolog of the Histidine Kinase RetS Controls the Synthesis of Alginates, PHB, Alkylresorcinols, and Motility in Azotobacter vinelandii. [PDF]
Curr MicrobiolRosales-Cruz A +6 more
europepmc +1 more source
Protein Science, Volume 35, Issue 8, August 2026.Abstract The Protein Data Bank (PDB), established in 1971, is the primary global, open‐access archive for experimentally determined 3D macromolecular structures (proteins, RNA, DNA). The research‐focused RCSB.org web‐portal provides access to these data alongside more than one million machine‐learning‐predicted structure models, greatly expanding the ...
Yana Rose +8 more
wiley +1 more source
The Pharmacology of the SLC15A4‐TASL Complex, an Emerging Target for the Treatment of Lupus
Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.ABSTRACT SLC15A4 is a member of the solute carrier superfamily that has been strongly linked to the pathogenesis of the auto‐immune disease SLE. The endo‐lysosomally localized SLC15A4 has traditionally been considered a proton‐dependent histidine and peptide transporter, but has also been shown to facilitate TLR7, 8, and 9 induced IFN‐alpha signaling ...
Alex L. Wilkinson +5 more
wiley +1 more source
Journal of Peptide Science, Volume 32, Issue 8, August 2026.Edge‐selective covalent grafting of poly‐arginine‐11 onto B60 graphene nanoparticles preserves the aromatic basal plane for π‐π immobilization of compound 8, highlighting this promising NEK6 inhibitor as the key therapeutic cargo in a peptide‐graphene nanoplatform for potential delivery.
Beatrice Scagnoli +10 more
wiley +1 more source
Bipolar Disorders, Volume 28, Issue 5, August 2026.ABSTRACT Background Cognitive impairment is common in bipolar disorder (BD), but the underlying pathophysiology remains unclear. This systematic review aimed to (1) summarize all literature describing relationships of biofluid biomarkers and cognition in BD and (2) identify which biofluid biomarkers correlate most consistently with cognition in BD ...
Alexandra J. M. Beunders +21 more
wiley +1 more source
GCB Bioenergy, Volume 18, Issue 8, August 2026.An experiment to map flooding tolerance in Miscanthus ×giganteus was conducted. Two phenotyping protocols (A and B) and different pipelines to call SNPs were used. TASSEL‐GBSv2 resulted in a genetic map with smaller QTL intervals than the other maps.
D. Zerpa‐Catanho +11 more
wiley +1 more source