Results 51 to 60 of about 87,659 (287)
Autophosphorylation of nucleoside diphosphate kinase on non-histidine residues [PDF]
, 1994 Recently, several reports appeared which described auto-phosphorylation of NDP kinase on residues different from the active-site histidine. Based on these findings conclusions were drawn with respect to a regulation of enzyme activity and to a possible ...
Bominaar, Anthony A. +5 more
core +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Cytokinin receptor: Just another histidine kinase [PDF]
, 2001 The cytokinin family of plant hormones is involved in diverse aspects of plant growth and development in vivo and in culture. Two groups have recently shown that a two-component histidine kinase functions as a cytokinin receptor specifically required for
Mark Estelle, Estelle, Mark
core +1 more source
Deletion of the HAMP domains from the histidine kinase CaNik1p of Candida albicans or treatment with fungicides activates the MAP kinase Hog1p in S. cerevisiae transformants [PDF]
, 2013 Microorganisms use two-component signal transduction (TCST) systems to regulate the response of the organism to changes of environmental conditions. Such systems are absent from mammalian cells and are thus of interest as drug targets.
El-Mowafy, Mohammed +5 more
core +3 more sources
A novel insight into ComE-mediated activation of gene expression in Streptococcus mutans
Microbiology SpectrumBacteria use two-component signal transduction systems (TCSs) to sense and respond to environmental changes. TCSs comprise a histidine kinase that senses environmental signals and a response regulator that regulates cognate promoters.
Hemendra Pal Singh Dhaked +2 more
doaj +1 more source
Modification of histidine repeat proteins by inorganic polyphosphate
Cell Reports, 2023 Summary: Inorganic polyphosphate (polyP) is a linear polymer of orthophosphate that is present in nearly all organisms studied to date. A remarkable function of polyP involves its attachment to lysine residues via non-enzymatic post-translational ...
Nolan Neville +6 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Structure of CheA, a Signal-Transducing Histidine Kinase [PDF]
, 1999 Histidine kinases allow bacteria, plants, and fungi to sense and respond to their environment. The 2.6 Å resolution crystal structure of Thermotoga maritima CheA (290-671) histidine kinase reveals a dimer where the functions of dimerization, ATP binding,
Bilwes, Alexandrine M. +3 more
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
MicroorganismsHistidine kinases are an integral component of bacterial two-component systems (TCSs), playing a pivotal role in signal transduction pathways, resulting in both resistance and virulence. However, their inherent membrane-bound nature often results in poor
Jude Kinkead +6 more
doaj +1 more source