Results 61 to 70 of about 5,123 (202)

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition [PDF]

, 2015
Resistance to the Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib has been attributed solely to mutations in BTK and related pathway molecules. Using whole-exome and deep-targeted sequencing, we dissect evolution of ibrutinib resistance in serial ...
Lander, Eric Steven
core   +1 more source

Histiocytic Sarcoma in the Brain of a Cat

Journal of Veterinary Medical Science, 2010
A mass lesion in the subependymal region of the lateral ventricle in a 13-year-old neutered male mongrel cat with a complaint of somnolence, right circling movement and posture abnormality was examined. The magnetic resonance image examination revealed a relatively large T1-hypointense and T2-hyperintense mass lesion in the left interventricular ...
Shinji Tamura, Hiroyuki Nakayama, Kazuyuki Uchida, Tetsuya Ide   +3 more
openaire   +4 more sources

Primary Head and Neck Histiocytic Sarcoma of the Oropharyngeal Posterolateral Wall: A Case Report

The Laryngoscope, EarlyView.
Histiocytic sarcoma (HS) is a rare and aggressive malignancy, particularly uncommon in the head and neck region. This report describes the case of a 67‐year‐old male with HS originating from the oropharyngeal posterolateral wall, treated successfully with transoral CO2 laser excision and adjuvant proton radiotherapy.
Michael Dalè, Giulia Gabella, Pietro Benzi, Valentina Campagnari, Marta De Vecchi, Monica Feltri, Marta Filauro, Giorgio Peretti, Giampiero Parrinello   +8 more
wiley   +1 more source

Effect of screening abdominal ultrasound examination on the decision to pursue advanced diagnostic tests and treatment in dogs with neurologic disease. [PDF]

, 2015
BackgroundAbdominal ultrasound examinations (AUS) are commonly performed before advanced neurodiagnostics to screen for diseases that might affect diagnostic plans and prognosis.ObjectivesDescribe the type and frequency of abnormalities found by AUS in ...
Blair, WH, Chen, RX, Sturges, BK, Taylor, SL, Tong, NM, Zwingenberger, AL   +5 more
core   +1 more source

Immunopathogenesis of canine chronic ulcerative stomatitis. [PDF]

, 2020
Canine Chronic Ulcerative Stomatitis is a spontaneously occurring inflammatory disease of the oral mucosa. An immune-mediated pathogenesis is suspected though not yet proven.
Anderson, JG, Bizikova, P, Ford, K, Jimenez, RJ, Kol, A, Murphy, BG, Stapelton, BP, Vasilatis, D, Villarreal, A   +8 more
core   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Histiocytic Sarcoma Involving Cervical Vertebra: A Case Report and Review of the Literature

Brain Sciences, 2022
Histiocytic sarcoma (HS) is a rare neoplasm composed of cells with immunohistochemical characteristics of mature histiocytes. It can be disseminated or localized and usually involves the skin, spleen, and gastrointestinal tract.
Eshagh Bahrami, Masoumeh Najafi, Amin Jahanbakhshi, Jaber Hatam, Saadat Molanaei, Patrizia Ciammella, Salvatore Cozzi   +6 more
doaj   +1 more source

The neural histogenetic origin of the oral granular cell tumor : an immunohistochemical evidence [PDF]

, 2011
Aims: Granular cell tumor (GCT) is a rare neoplasm that can appear in any site of the body, but most are located intraorally. Its histogenetic origin remains unclear. This report analyzes the immunoprofile of 15 cases of granular cell tumors, occurring
Campos, Marcia Sampaio, Cortes, Arthur Rodriguez Gonzalez, Júnior, Décio-dos-Santos-Pinto, Rejas, Roberto A. García, Sousa, Suzana COM de   +4 more
core   +1 more source

Hemophagocytic histiocytic sarcoma in feline [PDF]

Ciência Rural, 2012
Cytological analysis of the pleural cavity becomes extremely important for the diagnosis of tumors that have no visible or palpable mass. The aim of this study is to report a case of hemophagocytic histiocytic sarcoma in a cat, a rare neoplasm, emphasizing the importance of laboratory tests, especially the analysis of effusions.
Luciele Varaschini Teixeira, Sonia Terezinha dos Anjos Lopes, Danieli Brolo Martins, Raqueli T. França, Cinthia M. Mazzanti, Anne Santos do Amaral   +5 more
openaire   +2 more sources