Results 61 to 70 of about 9,024 (264)
Cancer Reports, 2022 Background Histiocytic sarcoma is a very rare monocyte/macrophage‐derived hematopoietic system tumor with a poor prognosis whose diagnosis is pathologically challenging due to its extreme rarity and histological overlap with various mimicking entities in
Nelson Montalvo +5 more
doaj +1 more source
Local Hydration Control and Functional Implications Through S-Nitrosylation of Proteins: Kirsten rat sarcoma virus (KRAS) and Hemoglobin (Hb) [PDF]
arXiv, 2022 S-nitrosylation, the covalent addition of NO to the thiol side chain of cysteine, is an important post-transitional modification (PTM) that can affect the function of proteins. As such, PTMs extend and diversify protein functions and thus characterizing consequences of PTM at a molecular level is of great interest. Although PTMs can be detected through
arxiv
Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice [PDF]
, 2016 The FDA approved drug rapamycin increases lifespan in rodents and delays age-related dysfunction in rodents and humans. Nevertheless, important questions remain regarding the optimal dose, duration, and mechanisms of action in the context of healthy ...
Anderson +33 more
core +1 more source
Conformational Fluctuations and Phases in Fused in Sarcoma (FUS) Low-Complexity Domain [PDF]
arXiv, 2023 The well known phenomenon of phase separation in synthetic polymers and proteins has become a major topic in biophysics because it has been invoked as a mechanism of compartment formation in cells, without the need for membranes. Most of the coacervates (or condensates) are composed of Intrinsically Disordered Proteins (IDPs) or regions that are ...
arxiv
Postradiation Histiocytic Sarcoma in the Setting of Muir-Torre Syndrome
Case Reports in Pathology, 2018 Hereditary nonpolyposis colorectal carcinoma (HNPCC) is an autosomal dominant genetic disorder characterized by a predisposition towards colorectal carcinoma and other extracolonic neoplasms.
Erin Baumgartner +6 more
doaj +1 more source
Veterinary Medicine and Science, 2022 A 9‐year‐old intact female chinchilla (Chinchilla lanigera) was presented to a referring veterinarian due to small, multiple cervical nodules that had been rapidly increasing in size and number.
Kaoru Enomoto +2 more
doaj +1 more source
Soft Tissue Sarcoma Co-Segmentation in Combined MRI and PET/CT Data [PDF]
arXiv, 2020 Tumor segmentation in multimodal medical images has seen a growing trend towards deep learning based methods. Typically, studies dealing with this topic fuse multimodal image data to improve the tumor segmentation contour for a single imaging modality. However, they do not take into account that tumor characteristics are emphasized differently by each ...
arxiv
Therapeutic targeting of chromatin alterations in leukemia and solid tumors
International Journal of Cancer, EarlyView.Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner +7 more
wiley +1 more source
Xist RNA Is a Potent Suppressor of Hematologic Cancer in Mice [PDF]
, 2013 SummaryX chromosome aneuploidies have long been associated with human cancers, but causality has not been established. In mammals, X chromosome inactivation (XCI) is triggered by Xist RNA to equalize gene expression between the sexes. Here we delete Xist
Brown, Diane E. +6 more
core +1 more source
Clinic-Pathological Aspects of Spleen Hemophagocytic Histiocytic Sarcoma in a Dog [PDF]
, 2021 Background: Histiocytes are cells that differentiate into macrophages and dendritic cell lines from bone marrow CD34+ stem cells. The hemophagocytic histiocytic sarcoma (HHS) is the only malignant neoplasm originating from macrophage lineages, being a ...
Cassali, Geovanni Dantas +3 more
core +2 more sources