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Pulmonary Langerhans Cell Histiocytosis

Seminars in Respiratory and Critical Care Medicine, 2020
AbstractPulmonary Langerhans cell histiocytosis (PLCH) is a diffuse cystic lung disease that is strongly associated with exposure to cigarette smoke. Recently, activating pathogenic mutations in the mitogen-activated protein kinase pathway have been described in the dendritic cells in patients with PLCH and have firmly established PLCH to be an ...
Brian, Shaw   +3 more
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Langerhans Cell Histiocytosis

New England Journal of Medicine, 1987
Nearly a century has passed since Alfred Hand reported a case of "polyuria and tuberculosis,"1 later considered to be the first case of the Hand-Schul1er–Christian syndrome.
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Adult Langerhans cell histiocytosis

European Journal of Haematology, 2006
Abstract:  Langerhans cell histiocytosis (LCH) is a proliferative histiocytic disorder of unknown cause originating from dendritic cells. The clinical presentation of LCH is highly variable. Although the features of this disease have been well described in children, they remain poorly defined in adults. Here, we review the current knowledge about adult
Marcus, Stockschlaeder   +1 more
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Choroidal Langerhans' cell histiocytosis

Acta Ophthalmologica Scandinavica, 2000
ABSTRACT.Purpose: To report a patient with choroidal Langerhans' cell histiocytosis.Methods: A solitary tumor was found in the left eye of a 49‐year‐old male who had no definite history of systemic disorders, but had observed visual disturbances for a period of 1 month.
I T, Kim, S M, Lee
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Pulmonary Langerhans' Cell Histiocytosis

Seminars in Respiratory and Critical Care Medicine, 2002
Pulmonary Langerhans' cell histiocytosis (PLCH) remains an important diagnostic consideration in the differential diagnosis of diffuse infiltrative lung disease, particular among smokers. This review highlights recent progress in our understanding of the etiology, clinical presentation, and diagnostic and therapeutic approaches to this unusual lung ...
Robert, Vassallo, Andrew H, Limper
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Pulmonary Langerhans’ cell histiocytosis

2007
Pulmonary Langerhans’ cell histiocytosis (PLCH) is a diffuse, smoking-related lung disease characterized pathologically by bronchiolocentric inflammation, cyst formation, widespread vascular ...
Harari S., Caminati A.
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Oral Langerhans cell histiocytosis

Journal of Cranio-Maxillofacial Surgery, 2002
Our aim is to compare the different methods of treatment available for Langerhans cell histiocytosis (LCH) in the oral and maxillo-facial region. A classification based on clinical and immunohistochemical data is proposed and a grading for the severity of the disease is proposed.Records and clinical data of 12 patients were evaluated retrospectively ...
Arnd, Bartnick   +3 more
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Unifocal Langerhans Cell Histiocytosis

Head and Neck Pathology
Langerhans cell histiocytosis is a rare disease which is more common in the childhood. Clinical presentation may vary ranging from single to multiple organ involvement. Skeleton is often involved and in the maxillofacial region, it affects the mandible more than the maxilla.
Vindhya, Savithri   +7 more
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Pulmonary Langerhans cell histiocytosis.

Irish medical journal, 2014
We report the case of a 57 year old man who presented with increased shortness of breath together with increased pulmonary nodules in his upper lobes over a two year period. His strong smoking history and pattern of distribution makes Langerhans cell Histiocytosis a likely diagnosis that was confirmed on biopsy.
Kooblall, M   +3 more
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