Sinus Histiocytosis with Massive Lymphadenopathy [PDF]
A 22-month-old child presented with massive cervical adenopathy accompanied by a retropharyngeal mass that caused stridor and dysphagia. Biopsy from both sides was consistent with sinus histiocytosis with massive lymphadenopathy (SHML). SHML is an unusual benign lesion that characteristically presents with painless, massive cervical adenopathy ...
David R Kelly
exaly +3 more sources
ALK-positive histiocytosis involving the cavernous sinus: A deceptive radiologic mimic of meningioma
Anaplastic lymphoma kinase (ALK)-positive histiocytosis is an uncommon condition, recently considered a separate condition from other histiocytosis by WHO 5th edition. It can involve intracranial structures.
Mohammadreza Alizadeh, MD +10 more
doaj +1 more source
Patient with Rosai-Dorfman-Destombes disease: 18F-FDG-PET/CT scan as a diagnostic tool
Rosai-Dorfman-Destombes disease (RDD) is a rare non-Langerhans cell histiocytosis, with sinus involvement and massive lymphadenopathy. RDD is usually self-limited; it can appear alone or related to other diseases. We present a 9-year-old male with biopsy
Luis C. Araujo Cachay
doaj +1 more source
Characteristics of histiocytic neoplasms presenting as breast masses. [PDF]
British Journal of Haematology, Volume 208, Issue 1, Page 358-362, January 2026.
Vougiouklakis T +10 more
europepmc +2 more sources
A case of disseminated extranodal Rosai–Dorfman disease diagnosed by skin manifestations
Rosai–Dorfman disease (RDD) is a rare non‐Langerhans cell histiocytosis that was first described as sinus histiocytosis with massive lymphadenopathy by Rosai and Dorfman in 1969.
Shintaro Saito +3 more
doaj +1 more source
Histological variability and the importance of clinicopathological correlation in cutaneous Rosai-Dorfman disease [PDF]
: Rosai-Dorfman disease is a benign histiocytic proliferative disorder of unknown etiology. The disease mainly affects lymph node tissue, although it is rarely confined to the skin.
Ana Gameiro +3 more
doaj +1 more source
Erdheim-Chester disease associated with myeloid neoplasm: Clinical features, molecular landscape, and treatment outcomes. [PDF]
Abstract Erdheim‐Chester disease (ECD) is frequently associated with clonal hematopoiesis and myeloid neoplasms (MN), but clinical phenotype and response to kinase inhibitors (KI) in this setting remain unclear. We analyzed 67 patients with ECD associated with MN (ECD‐MN) from a French national cohort and assessed ECD treatment response, MN progression,
Le Pogam A +22 more
europepmc +2 more sources
Sinus Histiocytosis with Massive Lymphadenopathy [PDF]
To date, the morphological aspects of sinus histiocytosis with massive lymphadenopathy (SHML) have been fully described. The disease is characterized by an enlargement of lymph nodes in which the sinuses are dilated and infiltrated by histiocytes, often phagocytosing lymphocytes.
SACCHI, Stefano +3 more
openaire +4 more sources
Clinicopathological Features, Treatment Response, and Outcome of Rosai‐Dorfman Disease in Two Children [PDF]
ABSTRACT Rosai‐Dorfman disease is a rare non‐Langerhans cell histiocytic disorder. It is common in male children and young adults of African descent. It is classified into sporadic and familial types. The most common clinical presentation is massive bilateral cervical lymphadenopathy associated with constitutional symptoms. Histiocytic emperipolesis is
Evele G, Francine K.
europepmc +2 more sources
Rosai‐Dorfman disease in 6‐year‐old child: Presentation, diagnosis, and treatment
Rosai‐Dorfman disease is referred to as sinus histiocytosis massive lymphadenopathy. We are reporting a rare case of Rosai‐Dorfman disease, a case of 6‐year‐old boy with a history of multiple painless submandibular and cervical lymphadenopathy.
Kalpana Giri +3 more
doaj +1 more source

