Results 11 to 20 of about 35,057 (247)

International expert consensus recommendations for the diagnosis and treatment of Langerhans cell histiocytosis in adults

Blood, 2022
Langerhans cell histiocytosis (LCH) can affect children and adults with a wide variety of clinical manifestations, including unifocal, single-system multifocal, single-system pulmonary (smoking-associated), or multisystem disease.
G. Goyal, A. Tazi, R. Go, K. Rech, J. Picarsic, R. Vassallo, Jason R. Young, C. Cox, J. V. van Laar, M. Hermiston, Xin-xin Cao, P. Makras, G. Kaltsas, J. Haroche, M. Collin, K. McClain, E. Diamond, M. Girschikofsky   +17 more
semanticscholar   +1 more source

Dabrafenib and trametinib in Langerhans cell histiocytosis and other histiocytic disorders

Haematologica, 2023
The standard treatment for Langerhans cell histiocytosis (LCH) is chemotherapy, although the failure rates are high. Since MAP-kinase activating mutations are found in most cases, BRAF- and MEK-inhibitors have been used successfully to treat patients ...
E. Cournoyer, Justin Ferrell, Susan F. Sharp, Anish Ray, Michael Jordan, C. Dandoy, M. Grimley, Somak Roy, Robert Lorsbach, A. C. Merrow, A. Nelson, Allison L. Bartlett, J. Picarsic, Ashish R Kumar   +13 more
semanticscholar   +1 more source

ALK+ histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition.

Blood, 2021
ALK-related histiocytosis (formerly ALK-positive histiocytosis) is a rare subtype of histiocytic neoplasm first described in 2008 in three infants with multisystemic disease involving the liver and hematopoietic system.
P. Kemps, J. Picarsic, B. Durham, Z. Hélias-Rodzewicz, L. Hiemcke-Jiwa, C. van den Bos, M. D. van de Wetering, C. V. van Noesel, J. V. van Laar, R. Verdijk, U. Flucke, P. Hogendoorn, F. J. S. H. Woei‐A‐Jin, R. Sciot, A. Beilken, F. Feuerhake, M. Ebinger, R. Möhle, F. Fend, A. Bornemann, V. Wiegering, K. Ernestus, T. Méry, O. Gryniewicz-Kwiatkowska, B. Dembowska-Bagińska, D. Evseev, V. Potapenko, V. Baykov, S. Gaspari, S. Rossi, M. Gessi, G. Tamburrini, S. Héritier, J. Donadieu, Jacinthe Bonneau-Lagacherie, Claire Lamaison, L. Farnault, S. Fraitag, M. Jullie, J. Haroche, M. Collin, J. Allotey, M. Madni, K. Turner, S. Picton, P. Barbaro, A. Poulin, Ingrid S Tam, D. El Demellawy, Brianna Empringham, J. Whitlock, A. Raghunathan, Amy A. Swanson, M. Suchi, Jon Brandt, N. Yaseen, J. Weinstein, I. Eldem, B. Sisk, V. Sridhar, Mandy M Atkinson, Lucas R Massoth, J. Hornick, S. Alexandrescu, K. Yeo, K. Petrova-Drus, S. Peeke, Laura Muñoz-Arcos, D. Leino, D. Grier, R. Lorsbach, Somak Roy, Ashish R. Kumar, Shipra Garg, Nishant Tiwari, K. Schafernak, Michael M. Henry, A. V. van Halteren, O. Abla, E. Diamond, J. Emile   +80 more
semanticscholar   +1 more source

Histiocytosis and the nervous system: from diagnosis to targeted therapies

Neuro-Oncology, 2021
Histiocytoses are heterogeneous hematopoietic diseases characterized by the accumulation of CD68(+) cells with various admixed inflammatory infiltrates.
F. Cohen Aubart, A. Idbaih, J. Emile, Z. Amoura, O. Abdel-Wahab, B. Durham, J. Haroche, E. Diamond   +7 more
semanticscholar   +1 more source

Langerhans cell histiocytosis: Version 2021

Hematological Oncology, 2021
Children with Langerhnans cell histiocytosis (LCH) develop granulomatous lesions with characteristic clonal CD207+ dendritic cells that can arise as single lesions or life‐threatening disseminated disease. Despite the wide range of clinical presentations,
N. Gulati, C. Allen
semanticscholar   +1 more source

Langerhans Cell histiocytosis.

Blood, 2020
Langerhans Cell Histiocytosis (LCH) is caused by clonal expansion of myeloid precursors that differentiate into CD1a+/CD207+ cells in lesions that leads to a spectrum of organ involvement and dysfunction.
C. Rodríguez-Galindo, C. Allen
semanticscholar   +1 more source

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source

Pulmonary Langerhans Cell Histiocytosis

Seminars in Respiratory and Critical Care Medicine, 2020
Pulmonary Langerhans cell histiocytosis (PLCH) is a diffuse cystic lung disease that is strongly associated with exposure to cigarette smoke. Recently, activating pathogenic mutations in the mitogen-activated protein kinase pathway have been described in
B. Shaw, M. Borchers, D. Zander, N. Gupta   +3 more
semanticscholar   +1 more source

Primary Langerhans Cell Histiocytosis of the Extrahepatic Bile Duct Occurring in an Adult Patient

Balkan Medical Journal, 2018
Background: Langerhans cell histiocytosis is characterized by an abnormal proliferation of neoplastic Langerhans cells. Langerhans cell histiocytosis commonly affects the pediatric population, whereas presentation in adults remains a rare event.
Ifeyinwa E. Obiorah, Alicia Henao Velasquez, Bhaskar Kallakury, Metin Özdemirli   +3 more
doaj   +1 more source

Langerhans cell histiocytosis on the penis: a case report

BMC Urology, 2006
Background Langerhans cell histiocytosis affects mainly young children and features an accumulation of CD1a+ dendritic Langerhans cells in the bone, skin, and other organs.
Kuroda Isao, Ashimine Satoshi, Ueno Munehisa, Hagiuda Jun, Ishizawa Keisuke, Deguchi Nobuhiro   +5 more
doaj   +1 more source