Erdheim Chester disease – 25 year history with early CNS involvement [PDF]
We report a case of Erdheim-Chester disease (ECD) with a 25-year history following initial presentation with diabetes insipidus and brainstem involvement.
Cohen, N +5 more
core +2 more sources
The Concise Guide to PHARMACOLOGY 2025/26: Transporters
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +28 more
wiley +1 more source
Langerhans Cell Histiocytosis (LCH) and Diabetes Insipidus with Mandibular lesion
Langerhans cell histicytosis (LCH) is a rare disorder that primarily affects children. Its occurrence in adult is very rare. We report a case of 42 year old female patient who presented polyuria and polydipsia, loosing teeth and diplopia added to symptom
Sayeh Alizad jahani +3 more
doaj
Somatic mutations in solid tumors: a spectrum at the service of diagnostic armamentarium or an indecipherable puzzle? The morphological eyes looking for BRAF and somatic molecular detections on cyto-histological samples [PDF]
This review article deals with the analysis and the detection of the morphological features associated with somatic mutations, mostly BRAF(V600E) mutation, on both cytological and histological samples of carcinomas.
Abildgaard +112 more
core +1 more source
Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis +9 more
wiley +1 more source
High viral load of Merkel cell polyomavirus DNA sequences in Langerhans cell sarcoma tissues. [PDF]
International audienceBACKGROUND: Langerhans cell (LC) sarcoma (LCS) is a high-grade neoplasm with overtly malignant cytologic features and an LC phenotype.
A Kanik +38 more
core +4 more sources
The conversion of lactate to lactyl‐CoA facilitates enzymatic histone lactylation, transforming glycolytic by‐products into an epigenetic regulatory mechanism for gene expression. Lactylation modification influences macrophage polarization towards M1 or M2 phenotypes, affecting outcomes in infection, cancer and fibrosis. Targeting lactylation modifiers
Houhua Guo +5 more
wiley +1 more source
The clinicopathological characteristics and differential diagnosis of histiocytosis
The histiocytosis is divided into Langerhans' cell histiocytosis (histiocytosis X) and non-Langerhans' cell histiocytosis (NLCH). The former mainly occurs in lymphatic hematopoietic tissue and often involves central nervous system (CNS).
Shi-zhu YU
doaj
Langerhans cell histiocytosis: Two clinical presentations in the same patient [PDF]
Langerhans cell histiocytosis (LCH) is a heterogeneous group of diseases characterized by a pathological proliferation of cells phenotypically similar to Langerhans cells.
Lobo, I. +4 more
core +1 more source
Langerhans cells : sensing the environment in health and disease [PDF]
In the last few decades, our understanding of Langerhans cells (LCs) has drastically changed based on novel findings regarding the developmental origin and biological functions of these epidermis-specific resident immune cells.
Deckers, Julie +2 more
core +2 more sources

