Histo-blood group antigen-binding specificities of human rotaviruses are associated with gastroenteritis but not with in vitro infection. [PDF]
Sci Rep, 2018 Human strains of rotavirus A (RVAs) recognize fucosylated glycans belonging to histo-blood group antigens (HBGAs) through their spike protein VP8*. Lack of these ligands due to genetic polymorphisms is associated with resistance to gastroenteritis caused
Barbé L +9 more
europepmc +2 more sources
Histo-Blood Group Antigen Phenotype Determines Susceptibility to Genotype-Specific Rotavirus Infections and Impacts Measures of Rotavirus Vaccine Efficacy. [PDF]
J Infect Dis, 2018 Background Lewis and secretor histo–blood group antigens (HBGAs) have been associated with decreased susceptibility to P[8] genotype rotavirus (RV) infections.
Lee B +16 more
europepmc +2 more sources
Maternal and Infant Histo-Blood Group Antigen (HBGA) Profiles and Their Influence on Oral Rotavirus Vaccine (RotarixTM) Immunogenicity among Infants in Zambia [PDF]
Vaccines, 2023 Live-attenuated, oral rotavirus vaccines have significantly reduced rotavirus-associated diarrhoea morbidity and infant mortality. However, vaccine immunogenicity is diminished in low-income countries.
Adriace Chauwa +12 more
doaj +2 more sources
PLoS Pathogens, 2019 Rotavirus is the leading agent causing acute gastroenteritis in young children, with the P[8] genotype accounting for more than 80% of infections in humans.
Roberto Gozalbo-Rovira +8 more
doaj +3 more sources
Human Norovirus Neutralized by a Monoclonal Antibody Targeting the Histo-Blood Group Antigen Pocket. [PDF]
J Virol, 2019 The emergence of new epidemic GII.4 norovirus variants is thought to be associated with changes in antigenicity and HBGA binding capacity. Here, we show that HBGA binding profiles remain unchanged between the 1974 and 2012 GII.4 variants, whereas these ...
Koromyslova AD +3 more
europepmc +2 more sources
Inhibition of histo-blood group antigen binding as a novel strategy to block norovirus infections. [PDF]
PLoS ONE, 2013 Noroviruses (NoVs) are the most important viral pathogens that cause epidemic acute gastroenteritis. NoVs recognize human histo-blood group antigens (HBGAs) as receptors or attachment factors.
Xu-Fu Zhang +5 more
doaj +2 more sources
Structural analysis of determinants of histo-blood group antigen binding specificity in genogroup I noroviruses. [PDF]
J Virol, 2014 Shanker S +5 more
europepmc +4 more sources
Structural analysis of histo-blood group antigen binding specificity in a norovirus GII.4 epidemic variant: implications for epochal evolution. [PDF]
J Virol, 2011 Shanker S +5 more
europepmc +4 more sources
Lack of Norovirus Replication and Histo-Blood Group Antigen Expression in 3-Dimensional Intestinal Epithelial Cells [PDF]
Emerging Infectious Diseases, 2013 Noroviruses (NoVs) are a leading cause of gastroenteritis worldwide. An in vitro model for NoV replication remains elusive, making study of the virus difficult.
Melissa M. Herbst-Kralovetz +10 more
doaj +2 more sources
Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen. [PDF]
Nature, 2012 As with many other viruses, the initial cell attachment of rotaviruses, which are the major causative agent of infantile gastroenteritis, is mediated by interactions with specific cellular glycans.
Hu L +7 more
europepmc +2 more sources