Histo-Blood Group Antigens in Children with Symptomatic Rotavirus Infection [PDF]
Viruses, 2019 Group A rotaviruses are a major cause of acute gastroenteritis in children. The diversity and unequal geographical prevalence of rotavirus genotypes have been linked to histo-blood group antigens (HBGAs) in different human populations.
Raúl Pérez-Ortín +5 more
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Lewis fucose is a key moiety for the recognition of histo‐blood group antigens by GI.9 norovirus, as revealed by structural analysis [PDF]
FEBS Open Bio, 2022 Noroviruses have been identified as major causative agents of acute nonbacterial gastroenteritis in humans. Histo‐blood group antigens (HBGAs) are thought to play a major role among the host cellular factors influencing norovirus infection.
Tomomi Kimura‐Someya +7 more
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The Association between Symptomatic Rotavirus Infection and Histo-Blood Group Antigens in Young Children with Diarrhea in Pretoria, South Africa [PDF]
Viruses, 2022 Objectives: Recently, histo-blood group antigens (HBGAs) have been identified as receptors or attachment factors of several viral pathogens. Among rotaviruses, HBGAs interact with the outer viral protein, VP4, which has been identified as a potential ...
Kebareng Rakau +6 more
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The Role of Histo-Blood Group Antigens and Microbiota in Human Norovirus Replication in Zebrafish Larvae [PDF]
Microbiology Spectrum, 2022 Human norovirus (HuNoV) is the major agent for viral gastroenteritis, causing >700 million infections yearly. Fucose-containing carbohydrates named histo-blood group antigens (HBGAs) are known (co)receptors for HuNoV.
Arno Cuvry +6 more
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Norovirus Binding to Ligands Beyond Histo-Blood Group Antigens [PDF]
Frontiers in Microbiology, 2017 Histo-blood group antigens (HBGAs) are commonly accepted as the cellular receptors for human norovirus. However, some human noroviruses have been found not to bind any HBGA ligand, suggesting potential additional co-factors.
Erin A. Almand +3 more
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Structural Constraints on Human Norovirus Binding to Histo-Blood Group Antigens [PDF]
mSphere, 2016 Human norovirus interacts with the polymorphic human histo-blood group antigens (HBGAs), and this interaction is thought to be important for infection. The genogroup II genotype 4 (GII.4) noroviruses are the dominant cluster, evolve every other year, and
Bishal K. Singh +2 more
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Journal of Microbiology, Immunology and Infection, 2023 Background: Pseudomonas aeruginosa is not a common enteric pathogen. The association between human histo-blood group antigens (HBGAs) and P. aeruginosa enteric infection has not yet been studied.
Chih-Hsien Chuang +5 more
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Gut Microbes, 2021 The study tested the hypothesis that harboring high levels of histo-blood group antigen-expressing Enerobactero cloacae is a risk factor for norovirus diarrhea. The fecal E. cloacae abundance in diarrheic norovirus positive (DNP), non-diarrheic norovirus
Cliff A Magwira +2 more
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Histo-blood group antigens as receptors for rotavirus, new understanding on rotavirus epidemiology and vaccine strategy
Emerging Microbes and Infections, 2017 The success of the two rotavirus (RV) vaccines (Rotarix and RotaTeq) in many countries endorses a live attenuated vaccine approach against RVs. However, the lower efficacies of both vaccines in many low- and middle-income countries indicate a need to ...
Xi Jiang, Yang Liu, Ming Tan
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Molecular basis of P[II] major human rotavirus VP8* domain recognition of histo-blood group antigens. [PDF]
PLoS Pathogens, 2020 Initial cell attachment of rotavirus (RV) to specific cell surface glycan receptors, which is the essential first step in RV infection, is mediated by the VP8* domain of the spike protein VP4.
Shenyuan Xu +10 more
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