Results 21 to 30 of about 10,874,130 (155)

The role of the blood group-related glycosyltransferases FUT2 and B4GALNT2 in susceptibility to infectious disease

open access: yesInternational Journal of Medical Microbiology, 2021
The glycosylation profile of the gastrointestinal tract is an important factor mediating host-microbe interactions. Variation in these glycan structures is often mediated by blood group-related glycosyltransferases, and can lead to wide-ranging ...
Alibek Galeev   +5 more
doaj   +1 more source

Galectin-4 N-Terminal Domain: Binding Preferences Toward A and B Antigens With Different Peripheral Core Presentations

open access: yesFrontiers in Chemistry, 2021
The tandem-repeat Galectin-4 (Gal-4) contains two different domains covalently linked through a short flexible peptide. Both domains have been shown to bind preferentially to A and B histo blood group antigens with different affinities, although the ...
Jon I. Quintana   +11 more
doaj   +1 more source

Genetic susceptibility to rotavirus infection in Chinese children: a population-based case–control study

open access: yesHuman Vaccines & Immunotherapeutics, 2021
Rotaviruses (RVs) are the leading cause of acute gastroenteritis in children, while histo-blood group antigens (HBGAs) are believed to be host attachment and susceptibility factors of RVs.
Jin-Xia Wang   +14 more
doaj   +1 more source

Histo-blood group antigens and rotavirus vaccine shedding in Nicaraguan infants. [PDF]

open access: yesSci Rep, 2019
ABO, Lewis and secretor histo-blood group antigens (HBGA) are susceptibility factors for rotavirus in a P-genotype dependent manner and can influence IgA seroconversion rates following rotavirus vaccination.
Bucardo F   +6 more
europepmc   +2 more sources

Microbiota-induced regulatory T cells associate with FUT2-dependent susceptibility to rotavirus gastroenteritis

open access: yesFrontiers in Microbiology, 2023
The FUT2 α1,2fucosyltransferase contributes to the synthesis of fucosylated glycans used as attachment factors by several pathogens, including noroviruses and rotaviruses, that can induce life-threatening gastroenteritis in young children.
Emmanuelle Godefroy   +13 more
doaj   +1 more source

Genogroup IV and VI canine noroviruses interact with histo-blood group antigens. [PDF]

open access: yesJ Virol, 2014
UNLABELLED: Human noroviruses (HuNV) are a significant cause of viral gastroenteritis in humans worldwide. HuNV attaches to cell surface carbohydrate structures known as histo-blood group antigens (HBGAs) prior to internalization, and HBGA polymorphism ...
Caddy S   +3 more
europepmc   +3 more sources

Assessment of the influence of ABO blood groups on oral cholera vaccine immunogenicity in a cholera endemic area in Zambia

open access: yesBMC Public Health, 2023
Background Histo-blood group antigens (HBGAs) which include the ABO and Lewis antigen systems have been known for determining predisposition to infections. For instance, blood group O individuals have a higher risk of severe illness due to V.
Caroline C. Chisenga   +9 more
doaj   +1 more source

Intestinal mucin-type O-glycans: the major players in the host-bacteria-rotavirus interactions

open access: yesGut Microbes, 2023
Rotavirus (RV) causes severe diarrhea in young children and animals worldwide. Several glycans terminating in sialic acids (SAs) and histo-blood group antigens (HBGAs) on intestinal epithelial cell (IEC) surface have been recognized to act as attachment ...
S.A. Raev   +3 more
doaj   +1 more source

Diversity in Rotavirus–Host Glycan Interactions: A “Sweet” SpectrumSummary

open access: yesCellular and Molecular Gastroenterology and Hepatology, 2016
Interaction with cellular glycans is a critical initial step in the pathogenesis of many infectious agents. Technological advances in glycobiology have expanded the repertoire of studies delineating host glycan–pathogen interactions. For rotavirus, the
Sasirekha Ramani   +3 more
doaj   +1 more source

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