Results 91 to 100 of about 211,384 (368)

HLA class I binding prediction via convolutional neural networks [PDF]

arXiv, 2017
Many biological processes are governed by protein-ligand interactions. One such example is the recognition of self and nonself cells by the immune system. This immune response process is regulated by the major histocompatibility complex (MHC) protein which is encoded by the human leukocyte antigen (HLA) complex.
arxiv  

PCSK9 Promotes the Malignancy of Triple‐negative Breast Cancer Cells by Reducing Cholesterol Levels at the Plasma Membrane to Activate EGFR and HER3

Advanced Science, EarlyView.
By decreasing cholesterol and lipid raft levels in the plasma membrane, proprotein convertase subtilisin/kexin type 9 (PCSK9) boosts human epidermal growth factor receptor 1 and 3 (EGFR and HER3) activation, driving tumor growth and metastasis in triple‐negative breast cancer (TNBC).
Tianhong Li, Renfei Wu, Kathy Qian Luo
wiley   +1 more source

The major histocompatibility complex: a model for understanding graft-versus-host disease.

Blood, 2013
Acute graft-versus-host disease (GVHD) afflicts as much as 80% of all patients who receive an unrelated donor hematopoietic cell transplant (HCT) for the treatment of blood disorders, even with optimal donor HLA matching and use of prophylactic ...
E. Petersdorf
semanticscholar   +1 more source

Pan‐Variant SARS‐CoV‐2 Vaccines Induce Protective Immunity by Targeting Conserved Epitopes

Advanced Science, EarlyView.
An integrative approach identifies conserved B‐cell and T‐cell epitopes within SARS‐CoV‐2 proteins, redirecting immune responses from variable to conserved regions. These epitopes elicit robust humoral and cellular immunity, neutralizing diverse viral variants. Promiscuous T‐cell epitopes demonstrate cross‐species efficacy, highlighting their potential
Masaud Shah, Sung Ung Moon, Ji‐Yon Shin, Ji‐Hye Choi, Doyoon Kim, Hyun Goo Woo   +5 more
wiley   +1 more source

Por un programa nacional de colecta y criopreservación de células de sangre de cordón en Cuba

Revista Cubana de Hematología, Inmunología y Hemoterapia
Durante los últimos 50 años, el trasplante alogénico de células progenitoras hematopoyéticas (CPH) se convirtió en un tratamiento cada vez más utilizado en la curación de hemopatías malignas y enfermedades no malignas y genéticas, como la drepanocitosis ...
René A Rivero Jiménez
doaj  

Use of Genome Information-Based Potentials to Characterize Human Adaptation [PDF]

arXiv, 2018
As a living information and communications system, the genome encodes patterns in single nucleotide polymorphisms (SNPs) reflecting human adaption that optimizes population survival in differing environments. This paper mathematically models environmentally induced adaptive forces that quantify changes in the distribution of SNP frequencies between ...
arxiv  

Ranking-based Convolutional Neural Network Models for Peptide-MHC Binding Prediction [PDF]

arXiv, 2020
T-cell receptors can recognize foreign peptides bound to major histocompatibility complex (MHC) class-I proteins, and thus trigger the adaptive immune response. Therefore, identifying peptides that can bind to MHC class-I molecules plays a vital role in the design of peptide vaccines. Many computational methods, for example, the state-of-the-art allele-
arxiv  

Identification of a Colonial Chordate Histocompatibility Gene

Science, 2013
A Gene for Early Acceptance One of the fundamental properties of the immune system is the ability to distinguish self- from nonself–histocompatibility. To gain insight into the evolution and molecular basis of histocompatibility, Voskoboynik et al.
A. Voskoboynik, Aaron M. Newman, Daniel M. Corey, D. Sahoo, D. Pushkarev, N. Neff, Benedetto Passarelli, W. Koh, K. Ishizuka, K. J. Palmeri, I. Dimov, C. Keasar, H. C. Fan, Gary L. Mantalas, Rahul Sinha, L. Penland, S. Quake, I. Weissman   +17 more
semanticscholar   +1 more source

Macrophage HM13/SPP Enhances Foamy Macrophage Formation and Atherogenesis

Advanced Science, EarlyView.
Previous research suggests that AIP may prevent atherogenic foamy macrophage formation. This study reveals that AIP, via its chaperone interaction with AHR, inhibits p38‐c‐JUN‐mediated transactivation of HM13, which encodes the ERAD protease HM13/SPP. HM13/SPP promotes foamy macrophage formation in addition to atherogenesis and plaque foamy macrophage ...
Yu Cao, Qirong Xie, Qiang Zheng, Jingping Zhang, Mengyu Yao, Zhongyong Du, Lujun Zhang, Tianyang Hu, Yunli Zhao, Jianlin Du, Yongyong Li, Yuxing Feng, ND Melgiri, Xiaodong Zhao, Rongzhong Huang, Yang Sun   +15 more
wiley   +1 more source

Current status and perspectives of the quality system in histocompatibility laboratories in Poland

Frontiers in Genetics
Allogeneic transplantation is a multi-step process involving many clinicians and laboratory personnel working together to achieve a common goal—to maximize the recipients’ chance of survival and to improve their quality of life.
Izabela Uhrynowska-Tyszkiewicz, Izabela Uhrynowska-Tyszkiewicz, Katarzyna Bogunia-Kubik, Monika Baj-Krzyworzeka, Monika Baj-Krzyworzeka, Barbara Piątosa, Barbara Piątosa   +6 more
doaj   +1 more source