Results 71 to 80 of about 197,788 (257)

IPD - the Immuno Polymorphism Database [PDF]

, 2005
The Immuno Polymorphism Database (IPD) (http://www.ebi.ac.uk/ipd/) is a set of specialist databases related to the study of polymorphic genes in the immune system.
Marsh, S.G.E., Robinson, J., Waller, M.J., Stoehr, P.   +3 more
core  

Participant demographic, histocompatibility data, immunosuppression and clinical outcomes.

, 2016
Participant demographic, histocompatibility data, immunosuppression and clinical outcomes.
Janet C. Siebert (260782), Holden T. Maecker (286420), Julie M. Yabu (3174753)   +2 more
core   +1 more source

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

DNA methylation profiling of the human major histocompatibility complex: A pilot study for the Human Epigenome Project [PDF]

, 2004
The Human Epigenome Project aims to identify, catalogue, and interpret genome-wide DNA methylation phenomena. Occurring naturally on cytosine bases at cytosine-guanine dinucleotides, DNA methylation is intimately involved in diverse biological processes ...
Gut, IG, Tost, J, Fischer, J, Hildmann, T, Lewin, J, Novik, KL, Beck, S, Cox, AV, Olek, A, Berlin, K, Otto, T, Howe, KL, Andrews, TD, Rakyan, VK   +13 more
core  

Transcriptomic analysis of major histocompatibility complex and interferon response in the hippocampus.

, 2020
(A) Major histocompatibility complexes I & II. (B) Interferon response genes.
Tian Wang (115287), Theodore P. Trouard (4045481), Yuan Shang (10555), Shuhua Chen (11649), Roberta D. Brinton (180782), Adam S. Bernstein (8275380), Yiwei Wang (403386), Zisu Mao (180765), Maunil Desai (8275377), Aarti Mishra (471065), Loi Do (2517820)   +10 more
core   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

16th IHIW: International Histocompatibility Working Group in Hematopoietic Cell Transplantation

, 2012
International audienceThe International Histocompatibility Working Group is a collaborative international effort to understand the HLA and non-HLA genetics of the transplantation barrier.
Petersdorf, Effie, W, Kawase, T, Gooley, T, Spierings, E, Petersdorf, E W, Shaw, B, Hsu, K, Fleischhauer, K, Tiercy, Jean-Marie, Morishima, Y, Tiercy, J-M, Cesbron, A, Dubois, V, Malkki, M, Madrigal, A, Velardi, A, Spellman, S, Dickinson, A, Bardy, P, Stern, M, Gooley, T., Bardy, P., Madrigal, A., Stern, M., Dubois, V., Petersdorf, E. W., Tiercy, J.-M., Kawase, T., Fleischhauer, K., Morishima, Y., Hsu, K., Spellman, S., Spierings, E., Velardi, A., Malkki, M., Dickinson, A., Cesbron, A., Shaw, B.   +37 more
core   +1 more source

Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity

Advanced Science, EarlyView.
Se‐Ssp was engineered as a potent immunomodulator for activating innate immunity via the TLR and cGAS‐STING pathways, therefore converting “cold” tumors into “hot” tumors to achieve high efficacy and long‐term therapeutic outcomes. ABSTRACT Immunotherapy has shed light on clinical oncology for several decades.
Yuqi Yang, Xiaowei Cai, Xiaoyan Zhong, Tian Qiu, Qinwei Lu, Jiahao Qin, Fei Gong, Yecheng Huang, Chenyu Jiang, Youdong Chen, Yuan Cheng, Liang Cheng   +11 more
wiley   +1 more source

Haplotype-Based Analysis of KIR-Gene Profiles in a South European Population—Distribution of Standard and Variant Haplotypes, and Identification of Novel Recombinant Structures

Frontiers in Immunology, 2020
Inhibitory Killer-cell Immunoglobulin-like Receptors (KIR) specific for HLA class I molecules enable human natural killer cells to monitor altered antigen presentation in pathogen-infected and tumor cells.
Elisa Cisneros, Manuela Moraru, Natalia Gómez-Lozano, Aura Muntasell, Miguel López-Botet, Miguel López-Botet, Carlos Vilches   +6 more
doaj   +1 more source

SynNotch Receptors for Visualizing Immunoreceptor Force Transmission and Downstream Signaling In Vivo

Advanced Science, EarlyView.
A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li, Jintian Lyu, Kaitao Li, Ameya Dravid, Deepali Balasubramani, Amir H. K. Ashkezari, Hyun‐Kyu Choi, Gabriel A. Kwong, Ankur Singh, Cheng Zhu   +9 more
wiley   +1 more source