Results 1 to 10 of about 104,008 (312)
Immunology of skin transplantation
Clinics in Dermatology, 2005 Untreated viable allogeneic skin is highly immunogenic. Epidermal Langerhans migrate after transplantation out of the donor skin into the lymph node of the recipient where they can activate T cells capable to mediate rejection. Allogeneic skin is used as a temporary coverage of burn wounds, often in combination with autologous skin grafts.
Richters, C.D. +4 more
openaire +4 more sources
NK and CD8+ T cell phenotypes predict onset and control of CMV viremia after kidney transplant
JCI Insight, 2021 CMV causes mostly asymptomatic but lifelong infection. Primary infection or reactivation in immunocompromised individuals can be life-threatening. CMV viremia often occurs in solid organ transplant recipients and associates with decreased graft survival ...
Harry Pickering +17 more
doaj +1 more source
ACTH treatment promotes murine cardiac allograft acceptance
JCI Insight, 2021 Heart transplantation is the optimal therapy for patients with end-stage heart disease, but its long-term outcome remains inadequate. Recent studies have highlighted the importance of the melanocortin receptors (MCRs) in inflammation, but how MCRs ...
Jing Zhao +13 more
doaj +1 more source
JCI Insight, 2021 Alloimmune responses driven by donor-specific antibodies (DSAs) can lead to antibody-mediated rejection (ABMR) in organ transplantation. Yet, the cellular states underlying alloreactive B cell responses and the molecular components controlling them ...
Kevin Louis +14 more
doaj +1 more source
IL-33 acts as a costimulatory signal to generate alloreactive Th1 cells in graft-versus-host disease
The Journal of Clinical Investigation, 2022 Antigen-presenting cells (APCs) integrate signals emanating from local pathology and program appropriate T cell responses. In allogeneic hematopoietic stem cell transplantation (alloHCT), recipient conditioning releases damage-associated molecular ...
Gaelen K. Dwyer +10 more
doaj +1 more source
Tregs integrate native and CAR-mediated costimulatory signals for control of allograft rejection
JCI Insight, 2023 Tregs expressing chimeric antigen receptors (CAR-Tregs) are a promising tool to promote transplant tolerance. The relationship between CAR structure and Treg function was studied in xenogeneic, immunodeficient mice, revealing advantages of CD28-encoding ...
Isaac Rosado-Sánchez +8 more
doaj +1 more source
IL-21–producing effector Tfh cells promote B cell alloimmunity in lymph nodes and kidney allografts
JCI Insight, 2023 Follicular helper T (Tfh) cells have been implicated in controlling rejection after allogeneic kidney transplantation, but the precise subsets, origins, and functions of Tfh cells in this process have not been fully characterized.
Hengcheng Zhang +12 more
doaj +1 more source
JCI Insight, 2020 Myeloid cells are increasingly recognized as major players in transplant rejection. Here, we used a murine kidney transplantation model and single cell transcriptomics to dissect the contribution of myeloid cell subsets and their potential signaling ...
Anil Dangi +8 more
doaj +1 more source
Human HLA-DR+CD27+ regulatory T cells show enhanced antigen-specific suppressive function
JCI Insight, 2023 Regulatory T cells (Tregs) have potential for the treatment of autoimmune diseases and graft rejection. Antigen specificity and functional stability are considered critical for their therapeutic efficacy.
Xiaoqian Ma +12 more
doaj +1 more source
Eosinophils restrain humoral alloimmunity after lung transplantation
JCI InsightWhile the function of many leukocytes in transplant biology has been well defined, the role of eosinophils is controversial and remains poorly explored. Conflicting data exist regarding eosinophils’ role in alloimmunity.
Zhongcheng Mei +17 more
doaj +1 more source