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Hilliard Seigler, M.D. and the origins of kidney transplantation and immunology at Duke [PDF]

Frontiers in Transplantation, 2023
The contributions of Dr. Hilliard Seigler to the founding of the Duke kidney transplantation program were considerable in both surgery and immunology. Some of these highlights are summarized based upon interviews with Dr. Seigler by the authors.
Stuart J. Knechtle, Justin Barr
doaj   +4 more sources

epiTOol: a browser-based HLA epitope (mis)matching application for small to large cohorts [PDF]

Frontiers in Immunology
MethodepiTOol is a web-based application for transplantation immunogenetics and immunology, providing easy and reliable translation of high-resolution HLA typing into either predicted or confirmed epitopes.
Claudia Lehmann, Claudia Lehmann, Nils Lachmann, Ilias Doxiadis, Ilias Doxiadis, Henry Loeffler-Wirth, Henry Loeffler-Wirth, Henry Loeffler-Wirth   +7 more
doaj   +2 more sources

Transplantation Immunology [PDF]

Methods in Molecular Biology, 2013
exaly   +2 more sources

Heterotopic intestine and abdominal wall transplantation in a miniature swine: A model for graft immunology

Kaohsiung Journal of Medical Sciences, 2023
In order to accurately monitor graft immunology, we have developed a method for performing intestine and abdominal wall transplantation heterotopically in miniature swine.
Yur‐Ren Kuo, Yu‐Han Chen, Yung‐Sung Yeh, Chao‐Wei Chang, Ching‐Chun Li, Ting‐Yu Cai, Han‐Ching Chang, Yu‐Tang Chang   +7 more
doaj   +1 more source

Development of heterotopic transplantation of the testis with the epididymis to evaluate an aspect of testicular immunology in rats. [PDF]

PLoS ONE, 2017
Transplantation of testicular cells and tissues has been studied for the investigation of immunology of the testis, which is an immunologically privileged organ.
Kai Yi, Naoyuki Hatayama, Shuichi Hirai, Ning Qu, Shogo Hayashi, Shinichi Kawata, Kenta Nagahori, Munekazu Naito, Masahiro Itoh   +8 more
doaj   +1 more source

Microsurgical techniques for experimental kidney transplantation and general guidelines to establish studies about transplantation immunology Técnicas microcirúrgicas para transplante renal experimental e condutas para estabelecer experimentos sobre imunologia do transplante

Acta Cirúrgica Brasileira, 2003
Experimental models of organ transplantation played a crucial role to establish the principles of transplantation immunology. The renal transplantation in rodents became the most used model to study the mechanisms of allograft rejection.
Paulo Ney Aguiar Martins, Alexander Filatenkov   +1 more
doaj   +1 more source

Transplants in annelids, nemerteans and planarians: a tool for embryology, immunology, endocrinology and regeneration research [PDF]

Invertebrate Survival Journal, 2015
While transplantation procedures are often associated with biomedical applications, they are also an invaluable tool for basic research. This review focuses on how transplantation techniques have been used to understand the biology of three large ...
E E Zattara
doaj   +1 more source

A single strain of Bacteroides fragilis protects gut integrity and reduces GVHD

JCI Insight, 2021
Graft-versus-host disease (GVHD) is a pathological process caused by an exaggerated donor lymphocyte response to host antigens after allogeneic hematopoietic cell transplantation (allo-HCT).
M. Hanief Sofi, Yongxia Wu, Taylor Ticer, Steven Schutt, David Bastian, Hee-Jin Choi, Linlu Tian, Corey Mealer, Chen Liu, Caroline Westwater, Kent E. Armeson, Alexander V. Alekseyenko, Xue-Zhong Yu   +12 more
doaj   +1 more source

Linked sensitization by memory CD4+ T cells prevents costimulation blockade–induced transplantation tolerance

JCI Insight, 2022
Dominant infectious tolerance explains how brief tolerance-inducing therapies result in lifelong tolerance to donor antigens and “linked” third-party antigens, while recipient sensitization and ensuing immunological memory prevent the successful ...
Michael S. Andrade, James S. Young, Jared M. Pollard, Dengping Yin, Maria-Luisa Alegre, Anita S. Chong   +5 more
doaj   +1 more source

Overexpression of PD-1 on T cells promotes tolerance in cardiac transplantation via ICOS-dependent mechanisms

JCI Insight, 2021
The programmed death 1/programmed death ligand 1 (PD-1/PD-L1) pathway is a potent inhibitory pathway involved in immune regulation and is a potential therapeutic target in transplantation. In this study, we show that overexpression of PD-1 on T cells (PD-
Thiago J. Borges, Naoka Murakami, Isadora T. Lape, Rodrigo B. Gassen, Kaifeng Liu, Songjie Cai, Joe Daccache, Kassem Safa, Tetsunosuke Shimizu, Shunsuke Ohori, Alison M. Paterson, Paolo Cravedi, Jamil Azzi, Peter T. Sage, Arlene H. Sharpe, Xian C. Li, Leonardo V. Riella   +16 more
doaj   +1 more source