Results 41 to 50 of about 813,932 (302)

Single cell transcriptomics of mouse kidney transplants reveals a myeloid cell pathway for transplant rejection

JCI Insight, 2020
Myeloid cells are increasingly recognized as major players in transplant rejection. Here, we used a murine kidney transplantation model and single cell transcriptomics to dissect the contribution of myeloid cell subsets and their potential signaling ...
Anil Dangi, Naveen R. Natesh, Irma Husain, Zhicheng Ji, Laura Barisoni, Jean Kwun, Xiling Shen, Edward B. Thorp, Xunrong Luo   +8 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Clonal expansion shapes the human Vδ1T cell receptor repertoire. [PDF]

, 2017
Cellular and Molecular Immunology aims to report the dynamic progress being made in China and abroad in immunological research, and welcomes high-quality Research Articles, Reviews and Brief Reports across a broad range of topics including, but not ...
Meraviglia S, Dieli F., Francesco Dieli, Serena Meraviglia   +3 more
core   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Half a century of Dutch transplant immunology

, 2014
The sixties have not only witnessed the start of the Dutch Society for Immunology (NvvI), but were also the flourishing beginning of the discipline of transplant immunology.
Cees van Kooten, Frans H.J. Claas, Brand, Anneke, Claas, Frans H J, Tilanus, Marcel G J, Rood, J.J. van, van Kooten, Cees, Tilanus, M.G.J., van Rood, Jon J, Jon J. van Rood, Kooten, C. van, Anneke Brand, Marcel G.J. Tilanus, Brand, A., Claas, F.H.J.   +14 more
core   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

What Is Hot and New in Basic and Translational Science in Liver Transplantation in 2023? Report of the Basic and Translational Research Committee of the International Liver Transplantation Society

The 2023 Joint Annual Congress of the International Liver Transplantation Society, European Liver and Intestine Transplant Association, and Liver Intensive Care Group of Europe were held in Rotterdam, the Netherlands, from May 3 to 6, 2023.
Martins, Paulo N, Abdelrahim, Maen, Sayed, Blayne Amir, Selzner, Markus, Mas, Valeria R, Bhat, Mamatha, Boteon, Yuri L, Pavan-Guimaraes, Juliana, Zarrinpar, Ali, Bonaccorsi-Riani, Eliano, Ghinolfi, Davide, MacParland, Sonya, Barbas, Andrew, Pang, Li, Meier, Raphael, Brüggenwirth, Isabel M A, Czigany, Zoltan, Ho, Cheng-Maw, Bonaccorsi Riani, Eliano, Dondossola, Daniele, Al-Adra, David, Emamaullee, Juliet, Yuksel, Muhammed, Brüggenwirth, Isabel M.A., Mas, Valeria R., Boteon, Yuri L., Martins, Paulo N.   +26 more
core   +1 more source

Pharmacokinetic/pharmacodynamic modelling approaches in paediatric infectious diseases and immunology [PDF]

, 2014
Pharmacokinetic/pharmacodynamic (PKPD) modelling is used to describe and quantify dose-concentration-effect relationships. Within paediatric studies in infectious diseases and immunology these methods are often applied to developing guidance on ...
Hoare, RL, Standing, JF, Lewis, J, Barker, CI, Germovsek, E, Lestner, JM   +5 more
core   +1 more source

Human HLA-DR+CD27+ regulatory T cells show enhanced antigen-specific suppressive function

JCI Insight, 2023
Regulatory T cells (Tregs) have potential for the treatment of autoimmune diseases and graft rejection. Antigen specificity and functional stability are considered critical for their therapeutic efficacy.
Xiaoqian Ma, Lu Cao, Martina Raneri, Hannah Wang, Qi Cao, Yuanfei Zhao, Naiara G. Bediaga, Gaetano Naselli, Leonard C. Harrison, Wayne J. Hawthorne, Min Hu, Shounan Yi, Philip J. O’Connell   +12 more
doaj   +1 more source